Background: Platelet levels plays a key role for determining insulin resistance by a simple test. The degree of platelet activation may be assessed by platelet indices such as platelet count, mean platelet volume (MPV), and platelet distribution width (PDW).
Objective and hypothesis: The aim of this study is to assess platelet count, MPV, and PDW as metabolic indicator in obese chlidren with or without insulin resistants.
Methods: Two hundred sixty seven obese patients (girl 160) and 50 (girl 25) controls were enrolled. Anthropometric measurements, triglyceride, total cholesterol, HDL cholesterol, LDL cholesterol, alanine aminotransferase, aspartate aminotransferase, uric aside, hemoglobin, platelet count, MPV, PDW, and insulin resistance by homeostasis model of assessment of insulin resistance and oral glucose tolerant test were investigated. Obese patients were grouped according to the insulin resistance.
Results: In obese group mean age was 11.5±3.2 years, BMI: 28.6±4.8, mean hemoglobulin level: 13±0.98 g/dl, mean platelet count: 328 500±155 191 mm3, PDW: 11.5±2.0, MPV: 9.8±0.98, LDL: 98±26 mg/dl and uric acide: 4.9±1.0 mg/dl. Uric acide is significantly higher in obese group (P<0.05) and there was no statistically significantly differences in platelet indices in two groups. Only uric aside and ALT levels were significantly different between obese and control group/and obese with ınsulin resistance (IR) and control group. Platelet counts, MPV, and PDW levels were not significant different in obese, obese with IR and control groups. But MPV inversely correlated with HOMA-IR, platelet counts, ALT, and LDL levels. MPV is positive correlated with PDW.
Conclusion: The relationship between platelet, MPV, PDW, and obesity have been shown previously demonstrated. But platelet indices may not to be related to the degree of obesity as we think.
20 - 22 Sep 2014
European Society for Paediatric Endocrinology