ESPE Abstracts (2014) 82 P-D-3-1-663

Hypovitaminosis D: Factors Affecting in Spanish Children and Adolescents

Rosaura Leisa, Rocio Vazqueza, Luisa Maria Seoaneb, Silvia Barja-Fernandeza,b, Isabel Martinez-Silvac, Concepcion M Aguilerad, Josune Olzad, Mercedes Gil-Campose, Lidia Castro-Feijoof, Carmen Cadarso-Suarezc, Angel Gild & Rafael Tojoa


aUnit of Investigation in Nutrition, Growth and Human Development of Galicia, Pediatric Department (USC), Complexo Hospitalario Universitario de Santiago (IDIS/SERGAS), Santiago de Compostela, Spain; bEndocrine Physiopathology Group, Complexo Hospitalario Universitario de Santiago (IDIS/SERGAS), Santiago de Compostela, Spain; cUnit of Biostatistics, Department of Statistics and Operations Research (USC), Santiago de Compostela, Spain; dDepartment of Biochemistry and Molecular Biology II, Institute of Nutrition and food Technology, Center for Biomedical Research (UGR), Granada, Spain; ePediatric Research and Metabolism Unit, Reina Sofia University Hospital (IMIBIC), Cordoba, Spain; fPediatric Endocrinology, Pediatric Department (USC), Complexo Hospitalario Universitario de Santiago (IDIS/SERGAS), Santiago de Compostela, Spain


Background: Vitamin D adequate concentration is essential for growth, development and health during vital cycle. Hypovitaminosis D pandemic is associated with a wide range of pathologies.

Objective and hypotheses: The objectives of the present study were to characterize vitamin D status in children and adolescents residing in Galicia (Northwest of Spain, latitude 43°N) and to determine if serum 25-hydroxy-vitamin D (25(OH)D) concentration is related to age, gender, pubertal period and adiposity.

Method: Serum 25(OH)D levels were measured by LIAISON method in 471 children and adolescents (2–18 years age) and analyzed in correlation to age, gender, pubertal period and adiposity, measured by BMI.

Results: An overall prevalence of hypovitaminosis D was present in the 67.1%. Females had significantly lower serum 25(OH)D levels (25.56±14.03 ng/ml) than males (29.71±17.10 ng/ml) (P=0.004). Lower 25(OH)D levels were found in pubertal (25.52±13.97) than prepubertal (29.21±16.83 ng/ml) (P=0.011) children. In children, an inverse lineal effect of BMI (P=0.015, lineal coefficient (β)=−0.3191) and age (P=0.043, lineal coefficient (β)=−0.4109) on 25(OH)D concentration was observed.

Conclusion: In conclusion, it was found a high prevalence of low vitamin D status levels in children and adolescents from Galicia. The association of age, gender, pubertal period and adiposity with 25(OH)D levels was established. Obese pubertal males are special risk group of hypovitaminosis D, so it is necessary to control their vitamin D levels to establish intervention and prevention strategies including vitamin D supplements.