Background: Obesity prevalence among children increased worldwide in last three decades. Childhood onset obesity is associated with increased mortality and morbidity related to cardiovascular diseases during adulthood. Dyslipidemia has a fundamental role in the pathogenesis of cardiovascular diseases.
Objective and hypotheses: This study is designed to evaluate the prevalence and related factors of dyslipidemia among obese children and adolescent.
Method: In this study obese cases of endocrinology out-patient clinic were evaluated retrospectively for dyslipidemia and related factors. In total, 823 obese individuals aged 218 years (mean 10.8±3.1 years, 55.8% female, 60.8% pubertal) with age and sex matched BMI above 95 percentile were included in the study. Mean BMI and BMI SDS was found 28.3±4.8 kg/m2 and 2.4±0.6 respectively. Dyslipidemia was defined as total cholesterol >200 mg/dl, triglycerides >150 mg/dl, LDL>130 mg/dl or HDL<40 mg/dl. Insulin resistance was evaluated using HOMA-IR index.
Results: Patients with both dyslipidemia and hepatosteatosis had higher levels of ALT, AST and TSH, and lower levels of free T4.
Conclusion: Dyslipidemia prevalence increases with obesity degree and older age. Dyslipidemia with concomittant hepatosteatosis influences both liver and thyroid function tests significantly.
20 - 22 Sep 2014
European Society for Paediatric Endocrinology