Background: Fasting blood glucose has been questioned as a sensitive screening method of dysglycemia in obese children, as good percentage with normal fasting glucose can had altered glucose tolerance test (GTT).
Objective and hypotheses: Evaluate the reproducibility of the results of the GTT in overweight children.
Method: We studied 120 children, 55 girls and 65 boys with BMI⊇P85. No genetic or hormonal abnormalities were detected. After a normal diet for the last 3 days and 8 h fast the day of the test, fast glucose was measured and a glucose load of 1.75 mg/kg body weight was given a and new glucose sample was measured after 3 h. After 7 days, without any change in diet or physical activity, a new test was done in the same way.
Results: 18 children (15%) (ten boys and eight girls) had abnormal glucose tolerance test with glucose post load of 168±15 mg/dl, ten of them had normal fasting blood glucose. In the second test of those only 6 (33%) had similar results and three of the normal results previously showed altered results with glucose post load of 155±14 mg/dl. No difference by sex was detected, and no correlation was found between BMI and the results of the GGT.
Conclusion: Fasting blood glucose may be insufficient in some cases to detect dysglyecmia, however, GGT results are not reproducible. Decision to do one or another test should be evaluated individually.
20 - 22 Sep 2014
European Society for Paediatric Endocrinology