ESPE Abstracts (2014) 82 P-D-3-2-988

Thyrotoxicosis in Childhood and Adolescents

Ana Hreniuc, Letitia Leustean, Ioana Bodescu, Ioana Hristov, Simona Gherasim, Cristina Preda, Carmen Vulpoi, Voichita Mogos & Christina Ungureanu


Department of Endocrinology, Iasi, Romania


Background: There are many aspects of the child thyrotoxicosis similar as in adult but there are also particular characteristics. Thyrotoxicosis is rare in childhood and in majority is about Grave’s Disease.

Study Group: 61 patients with ages between 9 and 19 years that were admitted for hyperthyroidism in our department for 19 years. The diagnosis was sustained by clinical signs, hormonal profile, and ultrasound and scintigraphy exam.

Results: The hyperthyroidism has higher incidence at girls 83.6% and at puberty 21.56% at age group10–14, 74.5% for 15–19 and only 5.8% cases between 5 and 9 years old. The great majority has Graves’s disease. Thyrotoxicosis in childhood and adolescence is a relatively rare disease,it is mostly due to Graves’ disease 75.4%, followed by toxic multinodular goiter 19.6% and toxic adenoma 4.91%. Clinical signs were in majority: weight lost, swatting, palpitations with tachycardia, emotional liability, irritability. Psychological and psychiatric exam was performed at 52% patients and revealed a great impact of the disease over the personality, possible to compartmental disorder: memories troubles, low scholar performance, anxiety, and psychical asthenia going to paranoid tendencies. The treatment was with antithyroid drugs 67.13% or surgery 32.7%. Radioiodine therapy was not performed because the law experience in our country with radioactive substances at children and due to no unit for radioiodine therapy in our centre.

Conclusion: The Grave’s disease is the most frequent form of thyrotoxicosis at children; A late diagnosis may deter growth and psychological disturbances. In our department oral therapy with antithyroid drugs is the first line treatment.

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