ESPE Abstracts

Background: Low bone mineral density (BMD) in patients with Turner syndrome (TS) has been reported in a considerable number of previous studies. Cortical and trabecular bone have been involved. Osteoporosis can be over diagnosed in TS patients with a short stature unless BMD measurements are adjusted for body size. Optimization of bone health in girls with TS requires a healthy active lifestyle, including adequate calcium, vitamin D, and hormonal replacement therapy, according to consensus guidelines.

Objective and hypotheses: The aim of this study is to evaluate BMD and vitamin D status in our population of TS and follow this group after substitution.

Method: A group of 32 girls and adolescents diagnosed as TS by karyotype, age ranged between 12 and 32 years, we had 14 monosomy, 07 mosaisms, and 11 structural abnormalities. Evaluated by osteodensitometry, measurement of vitamin D, PTH, calcium, and phosphorous. The age of spontaneous or induced puberty, the GH treatment and fracture history were precise.

Results: The mean age of this group is 21 years, The BMD was low in all patients with osteopenia in 35% and osteoporosis in 57% and normal BMD in 7% of cases this group had treated early by GH and their puberty are early induced, vitamin D status is very low in all patients, calcium was low in just three cases and PTH was high in two patients with normal calcemia and very low vitamin D. Seven patients received take vitamin D orally and have standardized their rates. The others patients received also vitamin D and their results are pending. osteodensitometries of control for all patients are ongoing.

Conclusion: Achieving optimal bone density is of critical importance for fracture prevention in TS, and should be pursued by timely introduction of hormone replacement therapy, adequate dose of estrogens during the young adult life, optimal calcium and vitamin D intake and regular physical exercise.