Objective: Obesity is associated with bone age (BA) advancement of unclear etiology. In animal study, insulin may directly modulate skeletal growth. Our objective was to investigate the association with BA maturation and insulin levels in children with overweight and obesity.
Methods: In this cross-sectional study of 42 prepubertal children, anthropometric data and hormonal values during oral glucose tolerance test were measured. Subjects were divided into two groups by the difference between BA and chronological age (CA) (noted as BACA).
Results: The study population included 26 (61.9%) males and 16 (38.1%) females with a mean age of 7.8±2.0 years. The advanced bone age group defined as BACA >1 year (n=25) had significantly higher HOMA-IR, fasting insulin levels and lower quantitative insulin sensitivity check index (QUICKI). Also, BACA was significantly correlated with weight SDS and QUICKI.
Conclusion: Skeletal age is more advanced in overweight and obese children with hyperinsulinemia and insulin resistance. These findings suggest that insulin may modulate skeletal growth.
20 - 22 Sep 2014
European Society for Paediatric Endocrinology