Background: Polycystic ovary syndrome (PCOS) is characterized by ovulatory dysfunction and excess androgen secretion. Androgens may affect bone marrow cells via androgen receptor which expressed in the bone marrow. Also it is known that especially testosterone increases hemoglobin and hematocrit concentrations.
Objective and hypotheses: Our aim in this study is to describe the relation between hyperandrogenism and complete blood count (CBC) parameters in adolescents with PCOS.
Method: The study group was consisted of 80 cases. Forty adolescents with PCOS were compared with an age-and BMI-matched group of 40 obese girls without PCOS. BMISDS in PCOS and obesity groups were 2.56±0.78 and 2.52±0.67 respectively (P>0.05). The mean age of patients with PCOS was 15.2±1.4 years, and in the obesity group it was 14.8±1.19 years (P>0.05). CBC parameters were compared between PCOS and obesity groups. Also the relationship between androgen levels and CBC parameters in the patients with PCOS was investigated.
Results: In PCOS patients, mean testosterone level was 0.75±0.18 ng/ml, free testosterone was 3.4±0.83 pg/ml and DHEAS was 294 μg/dl. There were no significant differences in hemoglobin (14.1±0.8 vs 13.8±0.94 g/dl), erythrocyte counts (5.03±0.66 vs 4.85±0.32 106/μl), hematocrit (5.03±0.66 vs 41.2±2.66%), thrombocyte counts (283±72 vs 298±52 103/μl), leukocyte counts (8.43±1.51 vs 8.2±2.02) between the PCOS and obesity groups without PCOS (P>0.05). There was no correlation between the level of testosterone, DHEAS and CBC parameters.
Conclusion: Effect of the testosterone on erythropoiesis dependent on dosage. Low level endogenous androgens may not affect CBC parameters in patients with PCOS.
20 - 22 Sep 2014
European Society for Paediatric Endocrinology