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54th Annual ESPE

Barcelona, Spain
01 Oct 2015 - 03 Oct 2015

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Barcelona, Spain; 1-3 October 2015 Further information

hrp0084p2-328 | Fat | ESPE2015

miR-122 and Non-Alcoholic Fatty Liver Disease in Prepubertal Obese Children

Inzaghi Elena , Brandt Stephanie , Roos Julian , Cianfarani Stefano , Nobili Valerio , Colajacomo Mauro , Battelino Tadej , Primoz Kotnik , Wabitsch Martin , Fischer-Posovszky Pamela

Background: The incidence of non-alcoholic fatty liver disease (NAFLD) is dramatically increasing among children worldwide. The gold standard for diagnosis is the liver biopsy. Reliable serum markers are lacking. Recently, circulating miRNAs have been studied as biomarkers of disease progression. Specifically, miR-122 was proposed as predictive marker for liver disease in adults, while no data are available for children.Objective and hypotheses: To inves...

hrp0084p2-329 | Fat | ESPE2015

Meteorin-Like (METRNL) Expression in Human Adipose Tissue is Associated with Adipocyte Hypertrophy and Inflammation and is Down-Regulated During Human Adipogenesis

Loffler Dennis , Rockstroh Denise , Schwartze Julian , Landgraf Kathrin , Korner Antje

Background: The new adipokine/myokine meteorin-like (Metrnl) has been proposed to be of interest for obesity and metabolic disease through its potential role for brown/beige fat thermogenesis and macrophage activation in mice. METRNL was reported to be expressed in white adipose tissue (AT) and upregulated during adipogenesis and by exercise and.Aims: In this study we analysed the expression of METRNL during human adipogenesis and its regulation...

hrp0084p2-330 | Fat | ESPE2015

Abdominal fat Distribution Measured by Magnetic Resonance Imaging in 197 Children Aged 10–15 Years – Correlation to Anthropometry and Dual X-Ray Absorptiometry

Tinggaard Jeanette , Hagen Casper P , Mouritsen Annette , Mieritz Mikkel G , Wohlfahrt-Veje Christine , Fallentin Eva , Larsen Rasmus , Christensen Anders N , Jensen Rikke B , Juul Anders , Main Katharina

Background: Obesity in childhood is defined by age- and sex-specific BMI cut-off values. However, BMI does not disclose the distribution of fat mass. Increased abdominal adipose tissue is associated with a higher risk of cardio-metabolic disease in adulthood. Thus, precise measurements of abdominal adipose tissue in children may enable early prevention of disease.Objective and hypotheses: To validate measurements of abdominal adipose tissue by anthropome...

hrp0084p2-331 | Fat | ESPE2015

Autonomic Nervous System Function Assessed by Heart Rate Variability in Children and Adolescents with Long Term Follow up of Craniopharyngioma

Jung Hae Woon , Kim Hwa Young , Lee Gyung Min , Kim So Youn , Jeong Kyung A , Choi Keun Hee , Lee Jieun , Lee Young Ah , Shin Choong Ho , Yang Sei Won

Background: Obesity is a well-recognized complication of craniopharyngioma. Increased hypothalamic involvement (HI) by the tumour and accordant treatment has been associated with greater obesity. Changes in hypothalamic control of the autonomic nervous system (ANS) have been implicated in the development of hypothalamic obesity however, long term changes in the ANS have not been assessed.Objective and hypotheses: We aimed to evaluate ANS activity using h...

hrp0084p2-332 | Fat | ESPE2015

SIRT1 and SIRT2 Gene Expression in Peripheral Blood Mononuclear Cells of Obese Children and Adolescents and their Relationship with Metabolic Parameters and Insulin Resistance

Nourbakhsh Mitra , Razzaghy-Azar Maryam , Arab Zahra , Pasalar Parvin , Golestani Abolfazl , Larijani Bagher

Background: Sirtuins are NAD+-dependant protein deacetylases that target histones, transcription factors, co-regulators, as well as metabolic enzymes to adapt gene expression and metabolic activity in response to the cellular energy state. SIRT1 and SIRT2 are two important enzymes of sirtuin family. SIRT1 has an important role in glucose metabolism and improves glucose homeostasis. It can also regulate fatty acid oxidation and hepatic cholesterol and bile acid metab...

hrp0084p2-333 | Fat | ESPE2015

Leptin Replacement Improves Central Ventilation in a Patient with Congenital Leptin Deficiency: First Report in Childhood

Lucaccioni Laura , Davies Philip L , Gibson Neil A , Farooqi Sadaf , Shaikh M Guftar

Background: Congenital leptin deficiency (CLD) is characterized by severe early-onset obesity due to hyperphagia and impaired satiety. The impact of obesity in obstructive sleep apnoea hypopnoea syndrome (OSAHS) was originally reported as mechanical, but recent data suggest that adipokines may influence central ventilation. We highlight that treatment with recombinant human leptin (RHL) in CLD with OSAHS improves ventilation before weight loss.Case prese...

hrp0084p2-334 | Fat | ESPE2015

Childhood Obesity Negatively Influences Adult Leydig Cell Function

Wagner Isabel V , Kloting Nora , Kiess Wieland , Soder Olle , Svechnikov Konstantin

Background: Childhood obesity is a global health problem and co-morbidities develop already during childhood and adolescence. Male obesity impacts negatively on reproductive function. Testosterone is decreased, sperm quality reduced, and the physical and molecular structure of germ cells altered in obese males. However, less is known about the role of prepubertal obesity on future reproductive function. We therefore explored Leydig cell function and reproductive potential in a...

hrp0084p2-335 | Fat | ESPE2015

Network Coordinated Primary Care Intervention in Obese Children and Adolescents: Almost a Decade of Experience

Guilmin-Crepon Sophie , Arsan Amine , Boizeau Priscilla , Alberti Corinne , Fidalgo Laurent , Chevallier Bertrand , Lubelski Patricia , Cheymol Jacques , Zaluski Alain , Tounian Patrick , Carel Jean-Claude , on behalf of REPOP Ile-de-France

Background: French health authorities have developed a national program to organize outpatient care networks for the prevention and management of obesity in children and adolescents (Réseau de Prise en Charge de l’Obésité Pédiatrique (REPOP)). To date, REPOP Ile-de-France has more than 250 primary care physicians with dietitians, nurses, educators, and psychologists trained in the management of childhood obesity as part of a standard care pathway, work...

hrp0084p2-336 | Fat | ESPE2015

Diagnosing the Metabolic Syndrome in Survivors of Childhood Haematopoietic Stem Cell Transplantation and Total Body Irradiation

Wei Christina , Hunt Linda , Elson Ruth , Cox Rachel , Bradley Karin , Shield Julian , Stevens Michael , Crowne Elizabeth

Background: The well-documented increased cardiometabolic risk in haematopoietic stem cell transplantation and total body irradiation (HSCT/TBI) survivors is under-recognised using standard (International Diabetes Federation (IDF)) metabolic syndrome (MetS) criteria. This is defined as the presence of central adiposity using increased waist circumference (WC) or BMI, (often not abnormal in HSCT/TBI survivors despite increased central adiposity), plus additional features includ...

hrp0084p2-337 | Fat | ESPE2015

Laparoscopic Sleeve Gastrectomy in Adolescents: Metabolic Consequences

Ybarra Marina , Franco Ruth , Cominato Louise , Velhote Manoel Carlos , Damiani Durval

Background: Severe obesity (SO), defined as BMI ≥95th percentile, has increased worldwide among adolescents. American studies estimated that 1.3–2.8% of 12–19-year-old individuals have a BMI >40 kg/m2 or a BMI >35 kg/m2 with at least one serious co-morbidity. The immediate and long-term risks associated with SO in adolescents include cardiovascular and metabolic diseases, obstructive sleep apnoea, and nonalcoholic fatty liver disea...

hrp0084p2-338 | Fat | ESPE2015

A Novel Melanocortin-4-Receptor Gene Mutation Associated with Early Onset Severe Obesity

Toumba Meropi , Shammas Christos , Neocleous Vassos , Phelan Marie , Skordis Nicos , Phylactou Leonidas , Mantzoros Christos

Background: The melanocortin-4-receptor gene (MC4R) is a key regulator for appetite and satiety. MC4R mutations account for 6–8% of severe obesity in children with variable expression and penetrance.Case presentation: A 3-year-old girl is presented with severe early onset and progressive obesity. She was born full-term with appropriate of gestational age weight by non-consanguineous parents. She had normal psychomotor milestones an...

hrp0084p2-339 | Fat | ESPE2015

Hypothalamic Obesity, Hyperphagia, and Hyperinsulinaemia: Time for a Paradigm Shift in Assumptions?

Gan Hoong-Wei , Leeson Clare , Aitkenhead Helen , Spoudeas Helen , Dattani Mehul

Background: Hypothalamic obesity (HyOb) is a syndrome of inexorable, treatment-resistant obesity seen after congenital (e.g. septo-optic dysplasia (SOD)) or acquired (e.g. tumour-related) hypothalamic damage, often co-existing with hyperphagia, panhypopituitarism, autism, sleep, and temperature dysregulation. Its pathophysiology is poorly understood but hyperphagia and excess caloric intake may be less important than previously thought.Objective and hypo...

hrp0084p2-340 | Fat | ESPE2015

Prevalence of Scoliosis in a Large Cohort of Paediatric and Adolescent Prader–Willi Syndrome: A Scottish–Italian study

Ciccone Sara , Fintini Danilo , Kyriakou Andreas , Bocchini Sarah , Crostelli Marco , Read Heather , Donaldson Malcolm , Cappa Marco , Shaikh Guftar , Crino Antonino

Background: A variable prevalence of scoliosis has been reported in Prader–Willi syndrome (PWS). Clinical detection can be challenging. The role of GH therapy (GHT) in the onset and progression of scoliosis remains controversial as does the modality of screening.Objective and hypotheses: To define the prevalence of scoliosis in our PWS patients and analyse the role of age, gender, genotype, BMI, and GHT on its onset and severity.<p class="abstex...

hrp0084p2-341 | Fat | ESPE2015

Palmitic Acid Could Modify Cognitive and Behavioural Functions Through Sex Specific Activation of Hippocampal Astrocytes

Frago Laura M , Freire-Regatillo Alejandra , Argente-Arizon Pilar , Argente Jesus , Chowen Julie A

Background: Prolonged poor dietary habits can result in hypothalamic inflammation and gliosis with more recent studies suggest that other brain areas may also be affected. Western or high fat diet intake has been associated with increased cognitive impairment and aberrant feeding behavior, with males and females being differentially affected. The hippocampus participates in both of these functions. Saturated free fatty acids can induce astrocyte inflammation and this could pot...

hrp0084p2-342 | Fat | ESPE2015

Changes in Insulin Sensitivity in Adolescents Who Underwent Bariatric Surgery: Effects of Laparoscopic Sleeve Gastrectomy and Laparoscopic Gastric Banding

De Filippo Gianpaolo , Pourcher Guillaume , Khen-Dunlop Naziha , Kyheng Christele , Dagher Ibrahim , Bougneres Pierre

Background: In adults, bariatric surgery has gradually emerged as a ‘metabolic’ surgery, able to rapidly improve metabolic disturbances linked to severe obesity. Even if type 2 diabetes is rare in european obese adolescents, alterations in insulin sensitivity are present in almost all.Objective and hypotheses: To evaluate the modification of insulin resistance (IR) and insulin sensitivity (IS) in severe obese adolescents who underwent bariatric...

hrp0084p2-343 | Fat | ESPE2015

Chronodisruption in Obese Children

Saner Christoph , Mullis Primus , Simonetti Giacomo D , Janner Marco

Background: Altered circadian and ultradian blood pressure (BP) and heart rate (HR) rhythmicity has been described in many diseases with increased cardiovascular risk.Objective and hypotheses: We tested the hypothesis that rhythmicity in obese children is changed, compared to healthy subjects.Method: Circadian and ultradian BP and HR rhythmicity was assessed with Fourier analysis from 24-h ambulatory BP measurement (ABPM) in 75 obe...

hrp0084p2-344 | Fat | ESPE2015

Configuring a Better Estimation of Obese Children’s Kidney Size

Soheilipour Fahimeh , Rahimzade Nahid , Jesmi Fatemeh , Pishgahroudsari Mohadeseh , Kaviani Sarah , Sadeghian Mahnaz , Almassinokiani Fariba

Background: Obesity ignites numerous health and psychosocial problems and is associated with various comorbidities. BMI is also independently associated with improved risk for numerous kidney disorders. As renal length is considered a vital parameter in the clinical assessment of renal patients, normal renal length has to be defined in accordance to BMI. The aim of this study is to define normal kidney length in obese children, comparing ultrasound measurements of the kidney l...

hrp0084p2-345 | Fat | ESPE2015

Early Onset of Adiposity Rebound is Associated with Higher Leptin Concentrations in 12-Year-Old Children

Koyama Satomi , Sairenchi Toshimi , Arisaka Osamu

Background: We previously reported that children with an earlier adiposity rebound (AR), which is defined as the time at which the BMI starts to rise after infancy, have a higher BMI and a greater atherogenic metabolic status at age 12. In addition, it has been reported that higher levels of leptin at age 3 is associated with greater weight gain and adiposity by age 7. This finding suggests that leptin resistance may begin in early childhood, even before age 3.<p class="ab...

hrp0084p2-346 | Fat | ESPE2015

Metformin Treatment for Obese Children and Adolescents with Insulin Resistance

Todorova Zdravka , Stefanova Elissaveta , Kazakova Krasimira , Yordanova Desislava

Background: Obesity in children is already a global health problem. Obese children and adolescents with insulin resistance provide the pediatric healthcare professionals management challenge. Obesity with insulin resistance, dyslipidemia and elevated blood pressure constitute the metabolic syndrome and each of these is an independent risk factor for cardiovascular disease (CVD). Metformin is well-established oral hypoglycaemic agent in the treatment of adult and young patients...

hrp0084p2-347 | Fat | ESPE2015

A Double-Blind, Placebo-Controlled Comparison of Cinnamon Extract to Metformin Effects upon Insulin Resistance, Apolipoprotein B:Apolipoprotein A1 Ratio, and BMI of Obese Adolescent Girls with Polycystic Ovary Syndrome

Salehpour Shadab , Setavand Somayeh , Onsori Samaneh

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies, affecting 5–10% of population. Insulin resistance, apolipoprotein B:apolipoprotein A1 ratio, and BMI commonly increases in obese PCOS patients and are among the indicators of the disease. On the other hand, metformin and cinnamon are generally believed to control these.Objective and hypotheses: To compare the effects of cinnamon with those of the metformin on in...

hrp0084p2-348 | Fat | ESPE2015

Pantoprazole Treatment of Exogenous Obesity and Hyperinsulinism in Childhood

Dogan Murat , Kaba Sultan , Bulan Keziban , Akgeyik Sukran , Dogan Sekibe Zehra

Aim: The purpose of this study was to assess whether pantoprazole could be a new treatment option in the therapy of children with obesity and insulin resistance.Methods: This study was conducted on 46 children and adolescents with exogenous obesity and insulin resistance. The patients were randomly chosen and divided into therapeutic groups of metformin, pantoprazole, and metformin plus pantoprazole.Results: There was no difference...

hrp0084p2-349 | Fat | ESPE2015

Subepicardial Adipose Tissue and Carotid Intima–Media Thickness in Obese Children and Their Relationship Between Metabolic and Clinical Parameters

Boyraz Mehmet , Uzun Fatma , Eminoglu Sancar

Introduction and objective: Atherosclerosis is one of the most important causes of obesity-related diseases. The clinical symptoms usually begin in adulthood, but the pathological changes in vascular structure could be observed in a much earlier period. Carotid intima–media thickness (cIMK) which is one of the noninvasive marker of early atherosclerotic changes, has been shown to be significantly increased in obese children. Subepicardial adipose tissue (SAT) is a compone...

hrp0084p2-350 | Fat | ESPE2015

The Switch in Eating Behaviour in Infants with Prader–Willi Syndrome is Associated with an Increase in the Acylated:Unacylated Ghrelin Ratio: Results of a Longitudinal Study

Kuppens Renske , van der Lely Aart Jan , Delhanty Patric , Huisman Martin , Hokken-Koelega Anita

Background: Prader–Willi syndrome (PWS) is characterized by a switch from failure to thrive to excessive weight gain and hyperphagia with impaired satiety in early childhood. An elevated, more unfavorable ratio between acylated:unacylated ghrelin (AG:UAG) may be involved in the underlying mechanisms of this switch.Objective and hypotheses: To assess the evolution of the appetite regulating hormones AG, UAG, and the AG:UAG ratio in infants with PWS a...

hrp0084p2-351 | Fat | ESPE2015

Domino Liver Transplantation for the Pre-Emptive Therapy of Compound Heterozygous Familial Hypercholesterolemia: A Case of 2-Year-Old Girl

Tanaka Hiroyuki , Sugawara Daisuke , Tanaka Yasuko , Yoshida Tomoko , Nakao Kanako , Uchida Noboru , Yamamoto Akiko , Fukuda Akinari , Kasahara Mureo , Horikawa Reiko

Background: Patients with homozygous and compound heterozygous familial hypercholesterolemia (FH) have markedly elevated plasma LDL cholesterol (LDL-C) from birth. If untreated, patients develop cardiovascular atherosclerosis resulting in death before the second decade of life. Medication and apheresis are only partially effective in reducing LDL-C levels, and do not significantly improve the prognosis. Liver transplantation (LT) can nearly normalize the cholesterol metabolism...

hrp0084p2-352 | Fat | ESPE2015

Metformin Prescriptions as a Proxy for Paediatric Type 2 Diabetes Burden

McNeill Ann Marie , Wang Tongtong , Chen Yong , Shankar Ravi

Background: Since metformin (MET), approved for treatment of type 2 diabetes (T2D), is the most commonly used oral anti-hyperglycaemic agent in youths MET prescriptions (Rx) could be used as a proxy for T2D burden in these populations. However, the extent of off-label use of MET in paediatrics is not well studied.Objective and hypotheses: Estimate the annual prevalence of ≥1 MET Rx among youths and calculate proportions with concomitant diagnoses o...

hrp0084p2-353 | Fat | ESPE2015

A New Mutation of PCSK1 Revealed by Neonatal Malabsorptive Diarrhoea, Panhypopituitarism, and Major Obesity

Bouhours-Nouet Natacha , Donzeau Aurelie , Decrequy Anne , Goideau Marion , Ziegler Alban , Colin Estelle , Bonneau Dominique , Coutant Regis

Background: Proprotein convertase subtilisin/kexin types 1 and 2 (PCSK1 and PCSK2) are expressed in neuroendocrine tissues where they cleave a subset of inactive prohormones into biologically active hormones, including pro-opiomelanocortin (POMC), proTRH, proinsulin, proglucagon, and proGnRH. Congenital deficiency of PCSK1 is a very rare syndrome causing malabsorptive diarrhea contrasting with severe early-onset obesity and hypopituitarism. We described here a new case of cong...

hrp0084p2-354 | Fat | ESPE2015

Overweight and Obesity in Childhood Cancer Survivors

Denzer Christian , Breuninger Louise , Steinbach Daniel , Cario Holger , Debatin Klaus-Michael , Wabitsch Martin

Background: Obesity is a potential late-effect of therapies for childhood cancer. Reported prevalence rates of obesity in childhood cancer survivors are heterogenous and currently unavailable for children treated according to protocols of the German Society for Paediatric Oncology. Furthermore, risk factors for the development of obesity following childhood cancer remain largely unknown.Methods: From a cohort of n=149 patients followed in a late...

hrp0084p2-355 | Fat | ESPE2015

Berardinelli Seip Congenital Lipodystrophy: A Light of Hope

del Campo Maria Ruiz , Moreno Isabel Saenz , Gonzalez Jose Julian Revorio , Araujo-Vilar David

Background: The lipodystrophy syndromes are a heterogeneous group of congenital or acquired disorders characterized by either complete or partial lack of adipose tissue (lipoatrophy). Berardinelli Seip congenital lipodystrophy (BSCL) is a rare metabolic disorder characterized by severe generalised lipodystrophy since birth, insulin resistance, and dyslipemia since early infancy.Case presentation: We report a 6-year-old girl who arrived from Pakistan with...

hrp0084p2-356 | Fat | ESPE2015

Physical and Metabolic Evolution of Obese Children and Adolescents after the Attainment of Intense Weight Reduction

Martos-Moreno Gabriel A , Martinez-Villanueva Julian , Gonzalez-Leal Rocio , Argente Jesus

Background: Despite the lack of drugs, conservative management of childhood obesity allows for considerable weight reduction.Objective and hypotheses: i) To evaluate anthropometric and metabolic changes in obese children after intense weight loss. ii) To analyze the influence of the amount of weight loss and the time spent to attain it on the observed changes. iii) To investigate BMI evolution during the first 3 years after weight reduction.<p class=...

hrp0084p2-357 | Fat | ESPE2015

TG:HDL Ratio as Best Predictor for IGT Screening in Overweight Children

Pellegrin Maria Chiara , Radillo Lucia , Grillo Andrea , Tornese Gianluca , Faleschini Elena , Ventura Alessandro

Background: The prevalence of dysglycaemia is high among overweight children and adolescents. Current screening criteria with fasting laboratory values have low sensitivity to detect IGT. Fasting triglycerides (TG) >1.17 mmol/l has been proposed as a criterion for screening obese children and adolescents at risk for IGT.Aims and objectives: We aimed to compare the performance of different screening criteria for detecting IGT in obese and overweight c...

hrp0084p2-358 | Fat | ESPE2015

Elevated Serum Irisin Level is not Related to Metabolic and Anthropometric Parameters in Obese Children

Abaci Ayhan , Catli Gonul , Tuhan Hale Unver , Anik Ahmet , Kume Tuncay , Calan Ozlem Gursoy , Bober Ece

Background: Irisin is a newly discovered myokine which regulates energy metabolism and obesity (type 2 diabetes pathogenesis). However, results of the clinical studies investigating the relation of irisin with metabolic and anthropometric parameters remain controversial, and studies in obese children are limited.Objective and hypotheses: We aimed to investigate the relation of serum irisin level with metabolic and anthropometric parameters in obese child...

hrp0084p2-359 | Fat | ESPE2015

FTO rs9939609 Polymorphism is Associated with the Presence of Obstructive Sleep Apnoea in Obese Youth

Kao Kung-Ting , Alexander Erin , Harcourt Brooke E , Saffery Richard , Wake Melissa , McCallum Zoe , Werther George , Sabin Matthew

Background: Emerging evidence suggests FTO polymorphisms are associated with obesity-related comorbidities including type 2 diabetes (T2DM), hypertension and polycystic ovarian syndrome (PCOS). However association of FTO with other comorbidities such as obstructive sleep apnoea (OSA) in paediatric populations is less clear.Objective and hypotheses: To investigate the prevalence of obesity-related comorbidities according to FTO genotype in an obese paedia...

hrp0084p2-360 | Fat | ESPE2015

Increasing Waist/Height Ratio and BMI Z-Score are Associated with Increased Comorbidities in Obese Youth, although Neither Accurately Identifies those with Abnormal Glucose Metabolism

Kao Kung-Ting , Alexander Erin , Harcourt Brooke E , McCallum Zoe , Wake Melissa , Werther George , Sabin Matthew

Background: At a population level, increasing age/sex corrected BMI Z-score (BMI-Z) is associated with increased risk of complications. It is unclear whether severity of obesity is a good predictor of comorbidities within groups of obese children. This knowledge is required to inform clinical management and pathways of care.Objective and hypotheses: In obese youth, to identify whether 1 increasing BMI-Z+/− waist/height ratio(WHtR) is associated wit...

hrp0084p2-361 | Fat | ESPE2015

Early Determinant Factors of Childhood Obesity

Awadalla Shokery

Background: Incidence of Obesity in infants is increasing with the risk to continue till adulthood with the entire health burden that can produce.Objective and hypotheses: To elucidate the early factors that can determine obesity we studied a group of obese children (group 1) compared with a control group regarding, mode of delivery, breast feed and its duration, age at start of solid food, and how take care of the child.Method: 23...

hrp0084p2-362 | Fat | ESPE2015

Nonalcoholic Fatty Liver Disease and Intestinal Inflammation in Obese Children

Abali Zehra Yavas , Saygili Seha , Ozden Tulin , Cantez Serdar , Bas Firdevs , Ertekin Vildan , Bundak Ruveyde , Durmaz Ozlem , Darendeliler Feyza

Background: The prevelance of pediatric obesity is increasing in childhood. Nonalcoholic fatty liver disease (NAFLD) is frequently associated with obesity, insulin resistance (IR), diabetes, and hypertriglyceridemia. Gut microbiota was suggested to play a role in both etiology of NAFLD and also progression to steatohepatitis. Feacal calprotectin (FCP) is a noninvasive marker of intestinal inflammation.Objective and hypotheses: To evaluate FCP and its ass...

hrp0084p2-363 | Fat | ESPE2015

Sleep and Weight Status at 4 Years in the Inma Asturias Cohort

Riano-Galan Isolina , Rodriguez-Dehli Cristina , Fernandez-Somoano Ana , Tardon Adonina

Background: Epidemiologic studies have documented that sleep duration is associated with obesity risk children’s.Objectives: To investigate sleep duration of 4-year-old children (h/day) and to evaluate the association of sleep patterns with weight status at 4 years.Methods: 393 children from the INMA birth cohort of Asturias (Spain). We analysed sleep duration (h/day) during the night and afternoon nap, reported by their paren...

hrp0084p2-364 | Fat | ESPE2015

Evaluation of Acylated Ghrelin and Obestatin Levels and Ghrelin:Obestatin Ratio in Obesity

Razzaghy-Azar Maryam , Nourbakhsh Mitra , Pourmoteabed Abdolreza , Nourbakhsh Mona , Illbeigi Davoud , Arab Zahra

Background: Ghrelin is 28-amino acid peptide predominantly produced by the stomach and have an orexigenic property as well as potent GH-releasing activity. Acylated ghrelin (AG) is the active form of this hormone. Obestatin is a 23-amino acid peptide, is produced by post-translational modification of a protein precursor that also produces ghrelin. Obestatin has the opposite effect of ghrelin on food intake.Objective and hypotheses: To evaluate acylated g...

hrp0084p2-365 | Fat | ESPE2015

A Novel MC4R Mutation Associated with Infancy-Onset Obesity

Goksen Damla , Onay Huseyin , Ozen Samim , Ozkinay Ferda , Darcan Sukran

Background: The melanocortin-4-receptor gene (MC4R) is a key regulator of energy homeostasis, food intake, and body weight which has intensively been analysed in molecular genetic obesity research. MC4R dysfunction in humans causes hyperphagia, impaired satiety and obesity. Most patients are heterozygotes, with some reports of homozygotes and compound heterozygotes.Objective and hypotheses: A 2-year-old boy with progressive weight gain from infa...

hrp0084p2-366 | Fat | ESPE2015

Homozygous Mutation in FBN1 Gene In-Patient with Prader–Willi Syndrome: Variant Marfan Syndrome?

van den Boom-Rijk Yvonne , Kempers Marlies , van der Sanden Ria Nijhuis , van Alfen-van der Velden Janielle

Background: Prader–Willi syndrome (PWS) is caused by absence of expression of imprinted genes on the paternal chromosome 15 (15q11.2–q13) due to a paternal deletion, maternal uniparental disomy 15 and rarely an imprinting defect. The clinical signs of PWS are hypotonia, muscle weakness, excessive eating, morbid obesity, delayed global development, hypogonadism, and short stature. Marfan syndrome is caused by mutations in the FBN1 gene, located on chromosome ...

hrp0084p2-367 | Fat | ESPE2015

Residual Excess Weight Difference Between BMI 35–40 and Over 40 After Laparoscopic Sleeve Gastrectomy in Severely Obese Adolescents: Midterm Outcomes

Linares Jeannette , Villagran Rodrigo , Gallardo Michael , Garcia Isabela , Araya Sofia , Flores Carlos , Cariaga Mario , Fuentes Paulina , Yanez Marisol

Background: Severe obesity among adolescents is increasing worldwide. Bariatric surgery is a controversial subject in this group of age, surgical timing is even more controversial. Patterns of surgical weight loss could be different between patients with greater excess weight, perhaps with less promising results.Objective and hypotheses: To compare anthropometric outcomes among adolescents with BMI 35–40 and over 40, underwent laparoscopic sleeve ga...

hrp0084p2-368 | Fat | ESPE2015

Effect of Visfatin on Gene Expression of Insulin Signaling Molecules in SW872 Adipocytes

Ruizhen Li

Background: To evaluate potential function of visfatin in SW872 adipocytes under the conditions which produce insulin resistance by free fatty acids (FFAs). Then to explore the mechanism of visfatin on the level of signal molecules.Objective and hypotheses: To evaluate the effects of visfatin on the mRNA expressions of the insulin signal molecules including insulin receptor substrate 1 (IRS1), IRS2, and phosphatidylinositol 3 kinase (PI3K) on the states ...

hrp0084p2-369 | Fat | ESPE2015

Childhood Obesity and Normocalcaemia with a GNAS Mutation also Present in Mother

Lim Sharon

Background: Assessment in childhood obesity includes looking for obesity syndromes. Dysmorphic features should guide investigations. When clinical signs are subtle, genetic investigations aide diagnosis. A case (S) of progressive childhood obesity is described. He was found to have a pathogenic GNAS mutation which was also present in his mother. Both mother and son had a similar phenotype and did not have hypocalcaemia or PTH resistance described in pseudohypoparathyr...

hrp0084p2-370 | Fat | ESPE2015

Information Technology Supported Treatment of Obese Children and Their Families: A Pilot Study

Lallemand Dagmar , Kowatsch Tobias , Pletikosa Irena , Brogle Bjorn , Dintheer Anneco , Wiegand Dunja , Durrer Dominique , Maass Wolfgang , Buchter Dirk

Background: Multiprofessional therapy programs for obese children and their families, including physical activity, nutritional, and behavioral interventions, have been shown to be effective, in group (MGP) as well as in individual (MIT) settings. However, due to limited personal and financial resources, <1% of children affected participate in such programs.Objective and hypotheses: Health IT systems (HIS) have the potential to improve therapy assisti...

hrp0084p2-371 | Fat | ESPE2015

Prevalence and Phenotypic Characterization of MC4R Mutations in a Large Paediatric Cohort

Vollbach Heike , Brandt Stephanie , Lahr Georgina , Wabitsch Martin

Background: The melanocortin-4-receptor (MC4R) plays a key role in body weight regulation. Hypothalamic activation of MC4R reduces food intake and increases energy expenditure. Mutations in the MC4R gene lead to the most common cause of monogenetic obesity. More than 150 different mutations are currently known. Their prevalence in obese subjects differs between 0.2 and 5.8%, depending on ethnicity, age and grade of obesity of the analysed cohort. Impact on phenotype a...

hrp0084p2-372 | Fat | ESPE2015

The Effect of ABCA1 Gene C69T Single Nucleotide Polymorphism on Dyslipidemia and Insulin Resistance in Obese Children

Ozgen Ilker Tolga , Erenberk Ufuk , Gok Ozlem , Kilic Ulkan , Bayraktar-Tanyeri Bilge , Torun Emel , Aksu Mehmet Sirin , Cesur Yasar

Background: ATP-binding cassette transporter A1 (ABCA1) mediates the transport of cholesterol and phospholipids from cells to lipid-poor apolipoproteins. It has been demonstrated that the ABCA1 gene C69T single nucleotide polymorphism (SNP; TT genotype) is associated with lower HDL cholesterol and higher triglycerides (TG) levels. The relation of this polymorphism with type 2 diabetes mellitus has also been shown.Objective and hypotheses: As dys...

hrp0084p2-373 | Fat | ESPE2015

Obese 5 Years Old Remain Obese at Age 12

Koyama Satomi , Yoshida Ayako , Arisaka Osamu

Background: Childhood obesity starts in early childhood. The natural history of childhood obesity has not been reported and it is unknown how obese children in early childhood improve to become non-obese adolescents.Objective and hypotheses: To investigate the natural history of obese children from early childhood to puberty and identify patterns and trends in this process.Method: 1207 children (614 boys and 593 girls) born in Fuji...

hrp0084p2-374 | Fat | ESPE2015

Lifestyle Habits and Arterial Hypertension in Children and Adolescents

Daratsianou Maria , Ioannidis Anastasios , Zyga Sofia , Koutsovitis Paraskevas , Sachlas Athanasios , Xrona Maria , Batsikoura Maria , Katsa Maria Efthymia , Magana Maria , Andronikakis Eleftherios , Gil Andrea Paola Rojas

Background: Elevated blood pressure (BP) may occur from childhood, increasing the risk for hypertension in adulthood.Aim: To investigate the effect of anthropometric characteristics and lifestyle habits in children’s and adolescents’ BP.Methods: 949 children (<12 years old) from Lakonia, 178 teenagers (12–18 years old) from Athens and 372 from Kalamata, Greece, had participated during 2011–2014. A specially ...

hrp0084p2-375 | Fat | ESPE2015

The Relation of Serum Nesfatin-1 Level with Anthropometric and Metabolic Parameters in Korean Children and Young Adolescents

Kim Shin-Hee , Ahn Moonbae , Jung In-Ah , Jeon Yeon Jin , Cho Won Kyoung , Cho Kyoung Soon , Park So Hyun , Jung Min Ho , Suh Byoung-Kyu

Background: Nesfatin-1, a recently discovered anorexigenic neuropeptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis.Objective and hypotheses: The aim of this study is to evaluate the relation of serum nesfatin-1 level with anthropometric and metabolic parameters in children and adolescents.Method: This study included 78 Korean children and adolescents (42 obese/overweight ...

hrp0084p2-376 | Fat | ESPE2015

Metabolic Syndrome Components of Normal Weight Central Obese Adolescents in Korea Stratified by Waist-To-Height Ratio: Results from K-NHANES 2008–2010

Cho Won Kyoung , Lee Hyun Young , Ahn Moonbae , Jung In-Ah , Kim Shin Hee , Cho Kyoung Soon , Park So Hyun , Jung Min Ho , Suh Byung-Kyu

Background: A subset of central obese but normal weight individuals has been identified, who harbor potentially increased risks for development of MS despite a normal BMI.Objective and hypotheses: We try to evaluate metabolic syndrome (MS) components of normal weight central obese adolescents in Korea stratified by waist-to-height ratio (WHR).Method: This is a cross-sectional study. Data were obtained from the Korean National Healt...

hrp0084p2-377 | Fat | ESPE2015

The Effect of Exenatide on Weight and Appetite in Overweight Adolescents and Young Adults with Prader–Willi Syndrome

Salehi Parisa , Hsu Isabel , Azen Colleen G , Mittelman Steven D , Geffner Mitchell E , Jeandron Debra

Background: Prader–Willi Syndrome (PWS) is a genetic disorder associated with hyperphagia and hyperghrelinemia with major morbidity due to obesity. The aetiology of hyperphagia is unknown, but presumed to be multifactorial, and, as ghrelin is orexigenic, high levels may contribute to weight issues in PWS. Currently, there is no effective medical treatment for hyperphagia in PWS, but targeting appetite could be beneficial. Exenatide (Byetta (synthetic exendin-4); AstraZene...

hrp0084p2-378 | Fat | ESPE2015

Early-Onset Obesity and Adrenal Insufficiency Associated with a Homozygous POMC Mutation

Meloni Antonella , Casini Maria Rosaria , Del Giudice Emanuele Miraglia , Boccone Loredana

Background: Isolated hypocortisolism due to ACTH deficiency is a rare condition that can be caused by mutations in the gene encoding pro-opiomelanocortin (POMC). POMC is the precursor to bioactive peptides (ACTH, β-endorphin, and α-β-γ-MSH). Mutations that inactive POMC typically result in secondary adrenal insufficiency, severe obesity and red hair; fewer than 50 affected individuals have been reported in the literature.Case presenta...

hrp0084p2-379 | Fat | ESPE2015

Clinical and Laboratory Differences between Metabolically Healthy and Unhealthy Obese Children

Elmaogullari Selin , Demirel Fatma , Hatipo Nihal

Background: Some obese children are metabolically healthy obese (MHO), while some are metabolically unhealthy obese (MUO) having dyslipidemia and/or insulin resistance which increase mortality and morbidity related to cardiovascular diseases during adulthood.Objective and hypotheses: This study is designed to assess factors affecting metabolic condition in obesity and compare clinical and laboratory findings between MHO and MUO children.<p class="abs...

hrp0084p2-380 | Fat | ESPE2015

Insulin Resistance and Abnormal Glucose Tolerance After Paediatric Hematopoietic Stem Cell Transplantation in Blood Cancer Survivors

Ciccone Sara , Bizzarri Carla , Pinto Rita Maria , Brescia Letizia Pomponia , Locatelli Franco , Cappa Marco

Background: Patients who had undergone hematopoietic stem cell transplantation (HSCT) during childhood have been reported to have a higher risk of early metabolic syndrome (MS) and diabetes mellitus (DM) with a consequent increased risk of cardiovascular disease. Previous studies reported a cumulative incidence of abnormal glucose tolerance of 11.6% at 5 years from HSCT and of 69.3% at 10 years and a prevalence of MS of 32% at 4 years from HSCT.Objective...

hrp0084p2-381 | Fat | ESPE2015

Metformin in Combination with Lifestyle Changes Effectively Reduces BMI and Waist Circumference in Overweight/Obese Children and Adolescents

Smetanina Natalija , Seibokaite Adrone , Valickas Raimondas , Kuprionis Gintaras , Grigoniene Jolanta Janina , Rokaite Ruta , Vitkauskiene Astra , Albertsson-Wikland Kerstin , Verkauskiene Rasa

Background: Overweight (OW) and obesity in paediatric population has been shown to be associated with an increase in prevalence of insulin resistance and type 2 diabetes (T2D) in youth.Objective and hypotheses: The aim of this study was to assess the efficiency and safety of metformin use in combination with lifestyle changes or alone for weight management in OW and obese (OB) children and adolescents.Methods: Study included 145 10...

hrp0084p2-382 | Fat | ESPE2015

Insulin-Like Factor 5 –A Novel Orexigenic Hormone in Humans is Dysregulated in Obesity

Wagner Isabel V , Flehmig Gesine , Scheuermann Kathrin , Loffler Dennis , Korner Antje , Kiess Wieland , Stumvoll Michael , Dietrich Arne , Blueher Matthias , Kloting Nora , Soder Olle , Svechnikov Konstantin

Background: Insulin-like factor 5 (INSL5), a member of the insulin superfamily, is expressed in the colorectum and hypothalamus. INSL5 levels are elevated by prolonged calorie restriction and declined with feeding, suggesting that it might be an orexigenic hormone.Objectives and hypotheses: Our aim was to explore the relationship between INSL5 and different metabolic parameters in lean and obese subjects and to identify possible links between INSL5 and t...

hrp0084p2-383 | Fat | ESPE2015

Tryptophan Supplementation as Conjunctive Therapy to Life Style Changes in Obese Adolescents

Jaramillo Adriana , Calderon Caterina , Llobet Marina , Sole Laura , Suarez-Ortega Larisa , Lerin Carles , Ramon-Krauel Marta

Background: The correlation between obesity and depression is well established. Tryptophan (Trp) is an essential amino acid that acts as substrate for serotonin and melatonin biosynthesis, both know to play a role in satiety, anxiety, and depression. Furthermore, low plasma Trp levels have been associated with obesity.Objective: To investigate the effects of Trp supplementation as a conjunctive therapy to conventional life-style intervention on weight lo...

hrp0084p2-384 | Fat | ESPE2015

Obesity in ROHHADNET Syndrome: Does Cortisol Play a Role?

van Tellingen Vera , van Trotsenburg Paul

Background: ROHHADNET syndrome is characterised by rapid onset childhood obesity, hypoventilation, variable hypothalamic-pituitary and autonomic dysfunction, and neuroendocrine tumors in 30–40%. Autoimmunity and paraneoplastic syndrome have been proposed as possible pathophysiological mechanisms, but the exact aetiology remains unclear.Objective and hypotheses: We present the clinical course of ROHHADNET syndrome in a 17-year-old girl, with consecut...

hrp0084p2-385 | Fat | ESPE2015

TNFα Downregulates CIDEC Via MEK/ERK-dependent PPARγ Phosphorylation and Nuclear Exportation in Human Adipocytes

Tan Xinrui , Xiao Yanfeng , Cao Zhenzhen

Background: Cell death-inducing DFF45-like effector C (CIDEC) is a novel lipid droplet-coating protein that promotes triglyceride accumulation and inhibits lipolysis. TNFα downregulates CIDEC levels to enhance basal lipolysis, while CIDEC overexpression could block this effect. However, the signalling mechanism by which TNFα regulates CIDEC expression in human is still unknown.Objective and hypotheses: The aim of this study was to investigate t...

hrp0084p2-386 | Fat | ESPE2015

The Sequence of Prenatal Growth Restraint and Postnatal Catch-Up Growth Leads to a Thicker Intima Media and More Pre-Peritoneal and Hepatic Fat by Age 3-6 Years

Sebastiani Giorgia , Diaz Marta , Bassols Judit , Lopez-Bermejo Abel , De Zegher Francis , Ibanez Lourdes

Background: Infants born small-for-gestational age (SGA) who develop postnatal weight catch-up are at risk for insulin resistance, central adiposity and cardiovascular disease in later life, even in the absence of overweight.Objective and hypotheses: In young (age 3–6 years) non-obese SGA children, we assessed arterial health by intima-media thickness (IMT) and abdominal fat distribution (subcutaneous, visceral, pre-peritoneal and hepatic components...

hrp0084p2-387 | Fat | ESPE2015

Biovascular Markers in Children with Kabuki Syndrome

Schott Dina , Kooger Berbel , Bierau Jorgen , Gerver Willem-Jan , Zimmermann Luc , Stumpel Constance

Background: Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of endothelial nitric oxide synthase (NOS), which prevents synthesis of nitric oxide (NO). Low levels of NO are associated with endothelial dysfunction and an increased risk of cardiovascular disease. Diseases associated with high levels of ADMA include metabolic syndrome, chronic kidney disease, diabetes mellitus, insulin resistance, hyperthyroidism and multiple organ failure. Notable, GH tr...

hrp0084p2-388 | Fat | ESPE2015

Phthalate Exposure and Metabolic Parameters in Korean Girls

Kim Shin Hye , Pyo Heesoo , Park Mi-Jung

Background: Phthalates are synthetic chemicals produced in extremely large volumes for a wide variety of uses in personal care and consumer products, including building materials, food packaging, medical devices, toys and cosmetics. Though a few studies have shown that concentrations of phthalate metabolites are associated with obesity and insulin resistance in adults, studies in children are limited.Objectives: We studied to examine the associations of ...

hrp0084p2-389 | Fat | ESPE2015

Childhood Craniopharyngioma with Hypothalamic Obesity – No Long-term Weight Reduction due to Rehabilitation Programs

Sterkenburg Anthe S , Hoffmann Anika , Gebhardt Ursel , Muller Hermann L

Background: Severe obesity due to hypothalamic involvement has major impact on prognosis in long-term survivors of childhood-onset craniopharyngioma. The long-term effects of rehabilitation efforts on weight development and obesity in these patients are not analysed up to now.Method: 108 patients with childhood-onset craniopharyngioma recruited in HIT Endo before 2001 were included in the study. Long-term weight development (BMI SDS after ...

hrp0084p2-390 | Fat | ESPE2015

Programming of Rat Behaviours and the Stress Response by Duration of the Infancy Stage

Crispel Yonatan , Katz Oren , Hochberg Ze'ev

Background: The age at weaning programs life history adaptively. Shorter infancy resulted in longer/thinner animals with a reproductive-strategic shift to earlier physical and sexual development (BMC Med, 2013).Hypotheses: The length of infancy impacts also the stress-response and has behavioural consequences.Method: Sprague-Dawley pups (generation F1), which usually are weaned at age 21 days, were weaned by cross-fostering at age ...

hrp0084p2-391 | Fat | ESPE2015

POMC DNA Hypermethylation Variant is Highly Associated with Obesity in Adults

Kuhnen Peter , Handke Daniela , Spranger Jochen , Fischer-Rosinsky Antje , Hinney Anke , Hebebrand Johannes , Gruters Annette , Krude Heiko

Background: POMC plays a major role in central body weight regulation. Recently we have shown that a POMC hypermethylation variant is significantly associated with obesity in children and adolescents (Kuehnen et al. PLoS Genetics 2012).Objective and hypotheses: Here we report about our extended studies to elucidate the mechanism behind the occurrence of the POMC hypermethylation variant in obese individuals.<p clas...