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54th Annual ESPE

Barcelona, Spain
01 Oct 2015 - 03 Oct 2015

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Barcelona, Spain; 1-3 October 2015 Further information

Poster Category 3


hrp0084p3-628 | Autoimmune | ESPE2015

Assessment of Ovarian Function and Reserve Based on Hormonal Parameters, Ovarian Volume, and Follicle Count in Euthyroid Girls with Hashimoto Thyroiditis

Kasikara Cigdem , Pirgon Ozgur , Demirtas Hakan , Dundar Bumin

Background: Among autoimmune disorders, autoimmune thyroid diseases are the most prevalent pathologies associated with premature ovarian failure.Objective and hypotheses: We aimed to investigate the ovarian function and reserve in euthyroid adolescents (TSH<2.5 mIU/l) diagnosed with Hashimoto thyroiditis (HT).Method: 30 adolescent girls (mean age 15.1±1.4 years) newly diagnosed as HT with presence of high thyroid antibodie...

hrp0084p3-629 | Autoimmune | ESPE2015

Early-onset Type 1 Diabetes and Multiorgan Autoimmunity in a Girl with Partial Monosomy 2q and Trisomy 10p

Bizzarri Carla , Matteoli Maria Cristina , Patera Ippolita Patrizia , Cappa Marco

Background: Genes in the HLA region confer about 50% of the genetic risk of type 1 diabetes (T1DM). More than 40 different genes give a minor contribution to T1DM risk, some of them are related to the immune function.Case presentation: A girl was referred at the age of 9 months with severe ketoacidosis in T1DM at onset. Anti-insulin autoantibodies were positive. She was the only daughter of unrelated Caucasian parents, born at term by vaginal delivery. T...

hrp0084p3-630 | Autoimmune | ESPE2015

CTLA4 A49G and C60T Genetic Polymorphism in Croatian Children and Young Adults with Autoimmune Thyroid Disease

Putarek Natasa Rojnic , Kusec Vesna , Grubic Zorana , Knezevic-Cuca Jadranka , Ille Jasenka , Stajnkler Biserka , Jaksic Bruna , Dumic Miroslav

Background: Autoimmune thyroid disease (AITD), including autoimmune thyroiditis (AT) and Graves’ disease (GD), is a complex autoimmune disease with a strong genetic component. The cytotoxic product of T-lymphocyte antigen-4 (CTLA4) gene, encoding a negative regulator of the T-lymphocyte immune response, was shown to be associated to AITD.Objective and hypotheses: To investigate the association of A49G and C60T polymorphisms of CTLA4 gene in populati...

hrp0084p3-631 | Autoimmune | ESPE2015

Oocyte Cryopreservation in a Patient with Premature Ovarian Failure due to Autoimmune Polyendocrine Syndrome Type 2

Balsamo Claudia , Porcu Eleonora , Baronio Federico , Forchielli Luisa , Bazzocchi Antonia , Mazzanti Laura , Cassio Alessandra

Background: Autoimmune polyendocrine syndrome type 2 (APS2) is a complex disorder characterised by the obligatory occurrence of Addison disease in combination with thyroid autoimmune disorder and/or type 1 diabetes. APS 2 is the most common autoimmune polyendocrine syndrome and is primarily manifest in adult age. Premature ovarian failure (POF) is defined as sustained amenorrhea before the age of 40 years, FSH levels higher than 40 UI/l and hypoestrogenism associated with infe...

hrp0084p3-632 | Autoimmune | ESPE2015

Thyroid Function and Autoimmunity in Children with Newly Diagnosed Type 1 Diabetes Mellitus

Niechcial Elzbieta , Skowronska Bogda , Gertig-Kolasa Anna , Krzysko Izabela , Stankiewicz Witold , Michalak Michal , Fichna Piotr

Background: Patients with type 1 diabetes (T1DM) are at a high risk of having other autoimmunological diseases. The most common coexisting disease is autoimmune thyroiditis, which is diagnosed in 15–30% diabetic patients. The incidence of the disease depends on the age, sex, and duration of T1DM.Aims and objectives: This study aims to assess the prevalence of anti-thyroid peroxidase antibodies and anti-thyroglobulin antibodies in children with newly...

hrp0084p3-633 | Autoimmune | ESPE2015

Hypercalcaemia as an Indication of Adrenal Insufficiency in a Patient with Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy

Dikaiakou Eirini , Vlachopapadopoulou Elpida-Athina , Anagnostou Elli , Panagiotopoulos Ioannis , Photinou Aspasia , Michalacos Stephanos

Background: Autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED), is a rare inherited disease of childhood, caused by the mutation of the AIRE gene on chromosome 21. It is characterized by three main diseases: chronic mucocutaneous candidiasis (CMC), chronic hypoparathyroidism (HP), and Addison’s disease (AD), and can be associated with other autoimmune diseases and/or manifestations of ectodermal dystrophy.Case...

hrp0084p3-634 | Autoimmune | ESPE2015

Stevens Johnson Syndrome in a Case with Type 1 Diabetes Mellitus: Relation or Coincidence?

Akin Onur , Doger Esra , Demet Akbas Emine , Bakirtas Arzu , Camurdan Orhun , Bideci Aysun , Cinaz Peyami

Background: Stevens-Johnson syndrome (SJS) is an acute life-threatening dermatosis characterised by conjunctivitis, oral ulcerations, fever, and erythematous macules. The most important etiological factors are infections and drugs including anticonvulsants and nonsteroidal anti- inflammatories.Objective and hypotheses: Cases with both SJS and type 1 diabetes mellitus have been reported rarely in the literature. Herein, we report a diabetic case of recurr...

hrp0084p3-635 | Autoimmune | ESPE2015

Radiologic Appearance is Important for Diagnosis of Autoimmune Hypophysitis

Sari Erkan , Yesilkaya Ediz , Akin Onur , Gursel Orhan , Sari Sebahattin

Background: Aetiologic causes should be evaluated in patients with central diabetes insipidus. Inflammatory and malign diseases must be exclude.Objective and hypotheses: A 9-year-old girl suffered from polyuria and polydipsia was diagnosed CDI. Adenohypohysis height and infudibulum thickness were increased 8 and 9 mm respectively. Physical findings were consistent with Tanner stage 1, height SDS −0.48, and BMI 91 percentile. Tumor markers and adeno...

hrp0084p3-636 | Autoimmune | ESPE2015

Functional Status of the Thyroid Gland in Children with Diabetes Mellitus Type 1

Latyshev Oleg , Samsonova Lubov , Okminyan Goar , Kiseleva Elena , Lobanov Yuryi , Latyshev Dmitriy

Background and aims: To investigate the functional status of the thyroid gland in children with diabetes mellitus type 1.Materials and methods: In the study were included 29 (13 boys, mean age 11.3±2.7 years) patients with diabetes mellitus type 1 from iodine deficient region. The examination included thyroid ultrasound and assessment of the functional state of the thyroid system: thyroid-stimulating hormone (TSH), fT4, fT3, th...

hrp0084p3-637 | Autoimmune | ESPE2015

About a Case of Basedow-Graves’ Disease in a Infant

Bassaid M A , Bouriche K , Senouci D , Mazari W , Kaddour F Hadj , Ghellai F , Bendjelloul A , Medjahdi A , Berber N , Bendeddouche A S

Background: A disease of the immune system, responsible for 95% of cases of hyperthyroidism in children is very rare at this age, it affects one child in 10 million.Presentation: Khadija 3 year old girl admitted for goiter, no goitrogenic substances No drug Shot, No Inbreeding, goiter paternal aunt, The trouble was in the beginning 1 year a height and weight advance:+1 DS weight, height+3.2 DS, weakness, weight loss, Profuse sweating, tachycardia, irrita...

hrp0084p3-638 | Autoimmune | ESPE2015

The Autoimmune Polyendocrinopathies in Children and Adolescents

Fedala Soumeya Nora , Haddam Ali El Mahdi , Ali Leyla Ahmed , Meskine Djamila , Chentli Farida

Background: PEA is a rare disease characterised by the coexistence of two endocrine autoimmune deficiencies, sometimes with a non-endocrine autoimmune disease associated concomittente of occurrence or metachronous way. Depending on the age of onset of the disease and the characteristics observed, we can distinguish several subgroups.Objective and hypotheses: Search frequency of PEA in children and adolescents and study their phenotype.<p class="abste...