ESPE Abstracts

Background: Technology applied to type 2 diabetes (T2D) is an area of investigation with important clinical applications.Objective and hypotheses: There are three issues which should be considered: is continuous subcutaneous insulin infusions (CSII) effective for treatment of T2D? What is the level of satisfaction and quality of life in T2D patients using CSII? Are CSII and glucose monitoring in T2D relevant from an economic perspective?<p class="abs...

Background: Very early onset diabetes mellitus (neonatal diabetes mellitus (NDM)) seems to be unrelated to autoimmunity in most instances. A number of conditions are associated with NDM, some of which have been elucidated at the molecular level. Among these, the recently elucidated mutations in the KCNJ11 and ABCC8 genes, encoding the Kir6.2 and SUR1 subunit of the pancreatic KATP channel involved in regulation of insulin secretion, account for one...

Neonatal diabetes is defined by hyperglycemia either isolated or as a part of a syndrome, diagnosed within the first 6 months of life. This is a monogenic form of diabetes resulting from mutations in a number of different genes encoding proteins that play a key role in the normal function of the pancreatic β-cell. To date, over 20 genes have been identified in about 60–75% of cases. A significant breakthrough was the recognition that a large portion of patients can b...

Background: The use of continuous glucose monitoring has been proven beneficial in improving glucose control. Nevertheless, its use by the patients is still limited with a high discontinuation rate, especially in the pediatric population. Real-life data showed a 30% adherence to treatment after 1 year of use.Objective and hypotheses: The most likely explanation for the sensor being underutilized is the significant burden related to its use fraught with t...

Background: Self-monitoring of blood glucose is an essential tool in the optimal management of childhood and adolescent diabetes. In the last 15 years, an extraordinary development of reliable devices for real-time continuous glucose monitoring (CGM) has taken place. Meanwhile, several trials in adults and children showed that CGM can be associated with improved glycaemic control, significant reduction of hypoglycaemia and better quality of life, particularly in those patients...

Type 2 diabetes mellitus (T2DM) is emerging as a new clinical problem within pediatric practice. Recent reports indicate an increasing prevalence of T2DM in children and adolescents around the world in all ethnicities, even if the prevalence of obesity is not increasing any more. There are great differences in T2DM prevalence worldwide. The majority of young people diagnosed with T2DM was found in specific ethnic subgroups such as African-American, Hispanic, Asian/Pacific Isla...

Background: Type 2 diabetes mellitus (T2DM) is a chronic and disabling disease affecting increasing numbers of adolescents. Conventional medical therapy presents unique challenges and seldom stalls progression.Objective and hypotheses: The objective of this presentation is to discuss the findings of contemporary, controlled, and prospective trials of surgical therapy for adult T2DM, which demonstrate dramatic early glycemic control, improvement in cardio...