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54th Annual ESPE

Barcelona, Spain
01 Oct 2015 - 03 Oct 2015

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Barcelona, Spain; 1-3 October 2015 Further information

Working Groups


hrp0084wg4.1 | Obesity | ESPE2015

The Endocrine Role of Brown Adipose Tissue

Villarroya Francesc

Background: The endocrine role of white adipose tissue (WAT), as a site of release of the so-called adipokines, has been recognized for long. Brown adipose tissue (BAT) is the main site of adaptive thermogenesis in mammals, especially relevant in neonates and early infancy. The amount and activity of BAT are associated with a healthy metabolic profile and protection against obesity, type II diabetes and hyperlipidemia. This biological role of BAT is traditionally attributed to...

hrp0084wg4.2 | Obesity | ESPE2015

A Monomeric Peptide Triagonist for the Treatment of Obesity and Diabetes

Clemmensen Christoffer , Finan Brian , Muller Timo , DiMarchi Richard , Tschop Matthias

Encouraged by unimolecular dual incretin co-agonists (GLP1/GIP) to enhance glycemic efficacy (Finan et al. 2013, Sci Transl Med) and GLP1/glucagon co-agonists to enhance weight loss efficacy (Day et al. 2009, Nat Chem Biol) and to restore diet-induced leptin sensitivity (Clemmensen et al. 2014, Diabetes), we recently developed the first tri-agonist (GLP1/GIP/glucagon) for the treatment of metabolic disorders (Finan et al. 2014, Nat Med). Importantly, this concerted triple agon...

hrp0084wg4.3 | Obesity | ESPE2015

Abstract unavailable....

hrp0084wg4.4 | Obesity | ESPE2015

Abstract unavailable....