Background: BMI has a negative impact on spontaneous and stimulated GH secretion in children, but the impact of BMI and free fatty acids (FFA) on peak stimulated GH values in Han children with short stature is unknown.
Objective and hypotheses: To assess the effects of BMI and FFA on peak GH values in Han children with short stature.
Method: This was a retrospective, cross-sectional study. We used arginineclonidine test to analyse the GHIGF1 axis in 657 Han children aged 216 years with short stature.
Results: BMISDS and total cholesterol (TC) were the only significant and negative predictors of peak GH (stepwise multiple regression; P=0.000; P=0.004). Increased BMISDS was associated with increased incidences of GHD and CGHD (χ2; P=0.000; P=0.000), the incidence of CGHD increased sharply with a BMISDS >2. Significant differences in BMISDS; TC and triglyceride (TG) levels were found among the peak GH categories (ANOVA; P=0.000, P=0.007, and P=0.001).
Conclusion: Our data confirm that BMI and TC have a negative impact on the peak GH response to arginineclonidine testing, the effects are particularly strong in obese children.
01 - 03 Oct 2015
European Society for Paediatric Endocrinology