ESPE Abstracts (2015) 84 P-3-1050

BMI and Total Cholesterol are Negative Predictors of Peak Stimulated GH in Han Children with Short Stature

Su Wu, Wei Gu, Ziyang Zhu, Shining Ni, Xing Shi & Qianqi Liu

Nanjing Children’s Hospital, Nanjing Medical University, Nanjing, China

Background: BMI has a negative impact on spontaneous and stimulated GH secretion in children, but the impact of BMI and free fatty acids (FFA) on peak stimulated GH values in Han children with short stature is unknown.

Objective and hypotheses: To assess the effects of BMI and FFA on peak GH values in Han children with short stature.

Method: This was a retrospective, cross-sectional study. We used arginine–clonidine test to analyse the GH–IGF1 axis in 657 Han children aged 2–16 years with short stature.

Results: BMI–SDS and total cholesterol (TC) were the only significant and negative predictors of peak GH (stepwise multiple regression; P=0.000; P=0.004). Increased BMI–SDS was associated with increased incidences of GHD and CGHD (χ2; P=0.000; P=0.000), the incidence of CGHD increased sharply with a BMI–SDS >2. Significant differences in BMI–SDS; TC and triglyceride (TG) levels were found among the peak GH categories (ANOVA; P=0.000, P=0.007, and P=0.001).

Conclusion: Our data confirm that BMI and TC have a negative impact on the peak GH response to arginine–clonidine testing, the effects are particularly strong in obese children.

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