ESPE Abstracts (2015) 84 P-2-281

Insulin Dynamics and Biochemical Markers for Predicting Impaired Glucose Tolerance in Thai Obese Youth

Sirapassorn Tirabanchasak, Sukumarn Siripunthana, Vichit Supornsilchai, Suttipong Wacharasindhu & Taninee Sahakitrungruang

Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

Background: Subjects with impaired glucose tolerance (IGT) are at risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease. The predictors of IGT in obese youth are not well described.

Objective and hypotheses: We aim to evaluate insulin dynamics and biochemical markers for predicting IGT in Thai obese youth.

Method: We studied 115 obese Thai children who underwent an oral glucose tolerance test (OGTT). Plasma glucose and insulin levels were calculated for assessment of β-cell function. Hemoglobin A1c (HbA1c), lipid profile, and clinical parameters were also used to determine predictors of IGT.

Results: We found that three patients had T2DM and 30 subjects had IGT. IGT patients had significantly higher fasting glucose, 1 h postload glucose, 2 h postload insulin, and lower whole-body insulin sensitivity indices than in normal glucose tolerance subjects whereas other indices were comparable. By ROC curve analyses, 1 h postload glucose was the best predictor of IGT, but fasting glucose or HbA1c represented a poor diagnostic tool for prediabetes screening. Subjects with 1 h OGTT glucose >155 mg/dl had significantly lower HDL levels, lower insulin sensitivity and more insulin resistance than those with 1-hr postload glucose of ≧155 mg/dl.

Conclusion: Abnormal glucose tolerance is highly prevalent in obese Thai youth. Several fasting indices and HbA1c fail to predict IGT. A 1 h OGTT glucose of >155 mg/dl appears to be more associated with adverse insulin dynamics and metabolic profile than 2 h postload glucose.

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