ESPE Abstracts (2015) 84 P-3-870

The Changes of Neuroendocrine Status in Children with Different Forms of Obesity

Olga Zagrebaevaa, Anzhalika Solntsavaa, Hanna Mikhnoa & Helena Dashkevichb

aBelarusian State Medical University, Minsk, Belarus; bTenth City Clinical Hospital, Minsk, Belarus

Background: Obesity is accompanied with the development of serious complications, including behavioural disorders. Obesity with impaired neuroendocrine status confirmed, but papers describing these interactions are a bit.

Objective and hypotheses: To compare the state of neuroendocrine status in children with various forms of obesity and normal weight control to the evaluation of central hormonal regulators of energy balance.

Method: We examined 315 children (236 obese, age 14.56±2 years, BMI 32.86±5.1 kg/m2; 79 normal weight (control), 14.51±2.2 years (P=0.95), 19.9±2.5 kg/m2 (P=0.0001)), observed in the endocrinology department of University clinic (Minsk) in 2013–2015. Obese children were divided into subgroups: simple (14.35±2 years, BMI<35 kg/m2) and morbid obesity (15.6±1.6 years, >35 kg/m2)). Patients underwent determination of dopamine, ghrelin, serotonin, neuropeptide Y, leptin and insulin levels with calculation of HOMA-IR. Results were processed using SPSS 18.0.

Results: Obese children showed a significant increase of dopamine values increase with increasing BMI as compared with the control ((pa-k=0.012), (pm-k=0.0001) (pa-m=0.009)). Leptin levels children with morbid and alimentary obesity were significantly higher than control ((pa-k=0.0001) (pa-m=0.0001), (pm-k=0.0001)). There were a significant decrease in the values of ghrelin in obese children ((pa-k=0.0001), (pm-k=0.0001)). A reduction of neuropeptide Y levels were showed in children with morbid and alimentary obesity compared to control ((pm-a=0.0001), (pa-k=0.0001) (pm-a=0.1)). Leptin levels positively correlated with BMI (alimentary – rs=0.26, P=0.005; morbid – rs=0.57, P=0.0001) and HOMA-IR (alimentary – rs=0.24, P=0.04, morbid – rs=0.41, P=0.002). Serotonon, ghrelin and NPY levels in severe obese patients were correlated with the presence of parental obesity (rs=0.43, P=0.0 2, rs=−0.26, P=0.03 and rs=−0.39, P=0.03 respectively).

Conclusion: Obese children had higher levels of dopamine and leptin with the reduction of NY and ghrelin concentrations.

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