ESPE2015 Poster Presentations Poster Category 1 Adrenal (11 abstracts)
Cortisol:Cortisone Ratio and Metalloproteinase 9 Emerging as Risk Factors Associated with Paediatrics Hypertension
Alejandro Martinez-Aguayo a , Carmen Campino b, , Rene Baudrand b , Cristian Carvajal b, , Constanza Pinochet a , Hernan Garcia a , Rodrigo Bancalari a , Alejandra Tapia a , Lorena Garcia c , Carolina Loureiro a , Carolina Mendoza a , Andrea Vecchiola b , Carolina Valdivia b, , Cristobal Fuente b , Carlos Lagos b , Francisca Grob a , Sandra Solari d , Fidel Allende d , Alexis Kalergis b, & Carlos Fardella b,
aDivision of Pediatrics, Pontificia Universidad Católica de Chile, Santiago, Chile; bDepartment of Endocrinology, Pontificia Universidad Católica de Chile, Santiago, Chile; cDepartment of Biochemistry and Molecular Biology, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile; dDepartment of Clinical Laboratories, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; eDepartment of Molecular Genetics and Microbiology, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, Chile; fDepartment of Celular and Molecular Biology, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
Background: Paediatric hypertension is increasing and has been associated with obesity and insulin resistance. Recently, cortisol:cortisone ratio and the metalloproteinase 9 (MMP9), which is a marker of vascular remodelling, have been syndicated as new risk factors associated with hypertension.
Objective and hypotheses: To analyse the association between paediatric hypertension with clinical, biochemical, inflammation, and vascular remodelling biomarkers
Method: A cross-sectional study was designed. We selected 320 subjects (4–16 years old, female 49.4%), anthropometric parameters, serum aldosterone (SA), plasma renin activity (PRA), cortisol, cortisone, HOMA-IR, hsCRP, adiponectin, IL6, TNFα, PAI1, MMP2, and MMP9 activities were measured. We calculated SA:PRA ratio (ARR >10, as screening of hyperaldosteronism) and serum cortisol:cortisone ratio as 11β-HSD2 activity estimation. The systolic and diastolic blood pressure indexes were calculated (SBPi and DBPi=observed/50th percentile blood pressure).
Results: According the Fourth Report of Task Force and JNC7, 59 children were hypertensive. Cortisol and cortisol:cortisone ratio were higher in hypertensive (P<0.001). No hyperaldosteronism was found. A positive linear correlation was observed between SBPi and DBPi with: BMI–SDS, HOMA-IR, cortisol:cortisone ratio, MMP2, and MMP9 activities. However, correlations with SA, PRA, and ARR were not significant. The variables associated with hypertension in the multivariate logistic model were: serum cortisol:cortisone ratio (OR: 4.73; CI=2.32–9.65), BMI–SDS (OR: 3.74; CI=1.91–7.32), MMP9 (OR: 3.48; CI=1.79–6.78), and HOMA-IR (OR: 2.20; CI=1.10–4.38). The other variables we did not correlate with blood pressure.
Conclusion: Novel biomarkers such serum cortisol:cortisone ratio and MMP9 activity emerged associated with paediatric hypertension. Further studies are needed to know the role of these markers in hypertensive patients.
Funding: This work was supported by Fondecyt 1130427 and 1150437, CORFO 13CTI-21526-P1 and IMII P09/016-F (ICM) Chilean Grants.
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Abstracts
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more