ESPE Abstracts (2015) 84 P-2-227

Longitudinal Bone Development in Patients with Classical Congenital Adrenal Hyperplasia: Data Using Peripheral Quantitative Computed Tomography

Susanne Bechtold, Leyla Duman, Claudia Weissenbacher, Julia Roeb, Robert Dalla Pozza & Heinrich Schmidt


University Children’s Hospital, Munich, Germany


Background and aims: Glucocorticoid treatment may influence bone and muscle development in patients with congenital adrenal hyperplasia (CAH). This study evaluated bone mineral density (BMD), bone geometry and muscle mass longitudinally throughout childhood.

Methods: 18 patients (ten males, eight females) with classical CAH were included. BMD, bone geometry and muscle mass were measured using peripheral quantitative computed tomography (pQCT) in prepubertal, midpubertal and postpubertal years.

Results: Mean age at first measurement was 9.70±1.95 years., at second 13.94±0.98 years. and at third 17.03±1.11 years. The corresponding bone ages were within a range of ±1 years for chronological age. In all, mean SD score for trabecular BMD decreased (from 0.77±1.24 to −0.32±1.12), whereas mean cortical BMD increased (from −0.40±1.39 to 0.74±1.18). Mean SD scores at first measurement for total (0.86±1.12) and medullary cross-sectional area (CSA) (2.10±1.17) were significantly elevated, also at all further time points, but decreased with time (−0.802 and −0.61 respectively; P<0.001). In all patients, SD score for relative cortical CSA (−1.32±01.16) was stable on a reduced level throughout childhood. After adjustment for lower height, muscle CSA was normal in all.

Conclusion: From childhood to adolescence we observed a reduction of trabecular BMD. There is an enlarged total and medullary CSA in CAH patients that decrease with time. Relative cortical CSA was reduced in all CAH patients. These longitudinal changes in bone geometry may have a long-term impact on bone stability.

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