ESPE Abstracts (2015) 84 P-2-238

Can Vitamin D Deficiency Cause Prolongation in Visual Evoked Potentials?

Murat Doğan, İlyas Aydin, Sultan Kaba, Keziban Aslı Bala & Özlem Gülpınar


aPediatrics, School of Medicine, Yuzuncu Yil University, Van, Turkey; bPediatrics D, Van Regional Training and Research Hospital, Van, Turkey


Objective: It is known that vitamin D has differential roles in cell proliferation, differentiation, neurotransmission and neuroplasticity in nervous system and exerts neurotrophic and neuroprotective effects. In recent studies, it was shown that vitamin D could be protective against in age-related macular degeneration and optic neuritis related to demyelinating disorders. Here, we aimed to perform visual evoked potential (VEP) studies before treatment in patients with rickets.

Material and method: This study included pretreatment VEP evaluations of 30 patients (aged 0–15 years) who were diagnosed as rickets in Child Endocrinology department of Yüzüncü Yıl University, Professor Dr Dursun Odabaş Medical Center between January, 2014 and July, 2014.

Results: Mean age was 2.15±4.12 years (min-max: 0.07–15.13) in 30 patients with rickets. There were eight girls (25.8%) and 23 boys (74.2%). When biochemical and hormone values were studied in patients with rickets, the following results were observed: mean calcium value, 8.09±1.52 mg/dl; mean phosphor value, 4.24±1.53 mg/dl; mean magnesium value 1.95±0.23 mg/dl; mean alkaline phosphatase value 838.23±627.86 U/l; mean parathormone value, 314.82±310.76 pg/ml; mean creatinine kinase value, 173.58±239.73 U/l; mean albumin value 4.05±1.41 g/dl; and mean 25 OH vitamin D level 5.52±3.20 ng/ml. When VEP results were assessed, mean P2 latency was 177.39±37.87 (min-max: 115.80–228) in left eye whie 177.0±932.30 (min-max: 120–230.4) in right eye in 27 patients. When LP 100 latency was evaluated in three patients, it was found that mean P100 latency was 113.50±3.25 (min-max: 109.80–115.80 in left eyes. The prolongation was detected in left eyes of six patients (20%) and right eyes of four patients (13.3%) in VEP studies.

Conclusion: We intended to emphasise that there could be prolongation in VEP studies in patients with rickets and that there should be need for detailed examination to monitor this prolongation in subsequent years.

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