Purpose: The purpose of this study was to assess the values of the mean platelet volume (MPV), a predictor of cardiovascular disease, in paediatric patients with attention deficit hyperactivity disorder (ADHD) and with autism spectrum disorders (ASD), in addition to healthy controls, to determine the risk of cardiovascular disease in these two disorder groups.
Material and method: The study included a total of 79 patients aged 318 with ADHD (36 patients) and with ASD (18) and controls (25) in the Van Region of Turkey. The control group included subjects of matching age and gender with no ADHD, ASD, and chronic disease and taking no vitamins. After measuring the weight and height of the patients in the groups, blood samples were obtained. The haematological parameters of the patients including MPV, vitamin B12, and vitamin D were assessed.
Results: The study included a total of 79 children and adolescents aged 218 (32 females and 47 males). Of the patients, 36 were in the ADHD group, 18 in the ASD group, and 25 in the control group. There was no statistically significant difference in haematological parameters between the groups, but there were significant differences in terms of vitamin D and vitamin B12. The patient groups showed lower levels of vitamin B12 and vitamin D when compared to the control group. In the ADHD group, there was a negative correlation between both vitamins and MPV (P<0.05). The partial correlation analysis of the ADHD group showed that in particular, MPV was negatively correlated to vitamin D, and not to vitamin B12 (P: 0.03).
Conclusion: The difference in MPV between the patient groups and the control group may be due to the limited number of patients studied. The vitamin D deficit particularly in the ADHD group may contribute to the elevated MPV value found by Yoruk and coworkers.
01 - 03 Oct 2015
European Society for Paediatric Endocrinology