ESPE Abstracts (2015) 84 P-3-1005

Incidence and Etiology of Hyperandrogenism in Children and Adolescent

Haddam Ali El Mahdia, Si Youcef Hafsab, Si Youcef Radhiac & Meskine Djamilaa

aEPH Ibn Ziri, Algiers, Algeria; bEPH Boussada, M’sila, Algeria; cCHU Mohamed Lamine Debaghine, Algiers, Algeria

Background: The hyperandrogenism in the teenager is a frequent reason for consultation. It poses diagnostic problems and sometimes therapeutic ones.

Objective and hypotheses: Search of the incidence and aetiology of hyperandrogenism in children and adolescent.

Method: This is a retrospective study of patients hospitalized for exploration of hyperandrogenism. 14 patients was for collected, all underwent to a profound clinical examination, gonadal and adrenal balance (FSH, LH, E2, testosterone, 17OHP, Androstendione) and a pelvic ultrasound imaging. The assessment was completed according to the context of the patient.

Results: The mean age of patients was 17 years, the beginning of the troubles was at the para-pubertal age (average age: 12 years). The delay in the consultation was due to a misunderstanding of the problem (n: 10) or the trivialisation of the late (n: 4). The reasons for consultation were: in 100% of cases hyperandrogenism, hyperandrogenism associated to menstrual disorders in 50%, primary amenorrhoea 7.14%, 35% of patients had PCOS (mean age 18 years) and 65% had an adrenal hyperplasia (CAH) has belatedly (mean age 17 years). The clinical status was characterised in the HCS by: severe hirsutism associated with signs of virilisation (clitoral hypertrophy). The cycle disorders were present in half of them; the spaniomenorhee was constant in the case of PCOS. Obesity was found in 70% of cases. Furthermore, note the absence of metabolic disorders. In the case of arrhenoblastoma, hyperandrogenism was moderate and there was a tumour syndrome.

Conclusion: The hyperandrogenism child and adolescent require careful exploration. An accurate diagnosis must be made for the rapid initiation of effective treatment.

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