ESPE Abstracts (2015) 84 P-3-1084


Plasma Kisspeptin Levels of Infants Breast Growth in Neonatal Period

Avni Kayaa, Zerrin Orbaka, Harun Polatb, Atilla Çayira, Abdullah Erdila & Hakan Döneraya


aDepartment of Pediatric Endocrinology, Faculty of Medicine, Ataturk University, Erzurum, Turkey; bDepartment of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey

Background: The studies investigating kisspeptin levels in the neonatal period is very limited.

Objective and hypotheses: This study was intended to investigate plasma kisspeptin hormone levels in newborns with or without breast growth.

Method: This prospective study was performed to determine plasma hormone levels of kisspeptin in patients admitted to the Erzurum Ataturk University Faculty of Medicine Research and Educational Hospital Pediatric Endocrinology Policlinic in September 2013–March 2014. Forty infants aged 14–28 days (20 girls and 20 boys) were included as the study group and 40 healthy infants (20 girls and 20 boys) as the control group. Two-milliliter venous blood samples were placed in hemogram tubes with K2EDTA. Plasmas were performed using the enzyme-immunoassay method. Kisspeptin levels were expressed as as ng/ml.

Results: Mean plasma kisspeptin levels in the breast growth group was 0.55±0.16 ng/ml and in the control group was 0.48±0.1613 ng/ml. Plasma kisspeptin levels differed significantly between the two groups (P=0.039). Significant correlations were determined between plasma kisspeptin levels and LH levels (P=0.05, r=0.312).

Conclusion: In this study, plasma kisspeptin levels were identified in newborns. Elevated kisspeptin in newborns breast growth shows that kisspeptin may be involved in the physiopathology of breast growth in newborns.

Funding: Funded by the Scientific and Technological Research Council of Turkey (TÜBİTAK).

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