ESPE2015 Poster Category 3 Thyroid (64 abstracts)
Effects of Subclinically Hypothyroidism on Haemorheological Parameters in Paediatric Population
Yasemin Isik Balci a , Sebahat Yilmaz Agladioglu b , Kadir Agladioglu c , Emine Kilic Toprak d , Ozgen Kilic Erkek d , Bayram Ozhan b , Aziz Polat a & Melek Bor Kucukatay d
aDepartment of Pediatric Hematology, School of Medicine, Pamukkale University, Denizli, Turkey; bDepartment of Pediatric Endocrinology, School of Medicine, Pamukkale University, Denizli, Turkey; cDepartment of Radiology, School of Medicine, Pamukkale University, Denizli, Turkey; dDepartment of Physiology, School of Medicine, Pamukkale University, Denizli, Turkey
Objective: Subclinical hypothyroidism (SH) prevalence in the paediatric population is reported between 1.7 and 9.5%. Results of the adult studies on SH showed that long term SH had negative effects on atherosclerosis, dyslipidaemia, insulin resistance and cognitive functions. The decision about treatment of SH in paediatric patients is still a matter of debate. None of the consensus statements published about the management of SH addressed the issue of SH in the paediatric population. Haemorheology, a branch of biorheology focuses specifically on blood and its interactions in both macro- and microcirculation under the influence of the applied constraints. Blood flow, RBC deformability and aggregation are main components of haemorheology. Effects of hypothyroid on haemorheology of patients had widely attracted the attention of researchers during last decade. The present study has been planned with the purpose to determine the effects of subclinically hypothyroidism on haemorheological parameters.
Method: 53 children with SH and 31 euthyroid healthy children (control group) were enrolled in the study. The groups had similar age, gender, puberty and BMI. Patients with obesity, chronic illness and other endocrine disorders were excluded. Venous blood samples were drawn after 8 hours of fasting and haemorheological parameters were carried out within 3 h after blood collection.
Results: The haemorheological parameters of SH group and healthy group shown in Table 1 and Table 2. These results indicate that haemorheological parameters are changing in children with SH.
Conclusions: The results of this study showed that SH is associated with haemorheological changes in children.
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