ESPE2015 Poster Category 3 Thyroid (64 abstracts)
The Role of Thyroid Fine-Needle Aspiration Cytology in the Treatment and Follow-Up of Thyroid Nodules in the Paediatric Population
Mikayir Genens a , Cansu Yilmaz c , Yasemin Ozluk b , Oguz Bulent Erol d , Zehra Yavas Abali a , Sukran Poyrazoglu a , Firdevs Bas a , Ruveyde Bundak a , Pinar Firat b , Dilek Yilmaz Bayhan b & Feyza Darendeliler a
aDivision of Pediatric Endocrinology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; bDepartment of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; cDepartment of Child Health and Disease, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; dDepartment of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
Background: Although thyroid nodules are rare in children compared to adults, the risk of malignacy is higher. Thyroid fine-needle aspiration (FNA) is a reliable diagnostic method used in the prediction of malignancy in the evaluation of thyroid nodules together with clinical and ultrasonographic findings.
Objective and hypotheses: To compare clinical, ultrasonographic, cytological and histopathological findings in patients who underwent FNA.
Method: The study included 80 (52 females, 28 males) patients who underwent FNA (n=107), for thyroid nodules at presentation or at follow-up. Clinical, ultrasonographic, cytological findings of patients were evaluated retrospectively.
Results: Mean age of the patients was 13.7±2.8 years during FNA. Autoimmune thyroiditis was present in 32.5% (n=26) and history of radiotherapy to the head or neck in 10% (n=8) The cytological diagnoses of patients included inadequate or hemorrhagic in 10% (n=8), benign in 42.5% (n=34), atypia or follicular lesion of undetermined significance (AUS/FLUS) in 15% (n=12) suspicion of follicular neoplasia (FN) in 7.5% (n=6), suspicion of malignancy (SM), in 8.8% (n=7) malignant in 16.3% (n: 13). There were no significant correlations between cytological findings and age, gender, erythrocyte sedimentation rate, thyroid hormones, thyroid autoantibodies and ultrasonographic findings of the thyroid nodules. 37 patients underwent thyroidectomy. The results of histopathological examination indicated 83.8% as malignant, 16.2% as benign. 25% of benign lesions according to cytological diagnosis was malignant, but all of malignant lesions were found malignant. Histopathologic examination was indicated as malignant in 25% of patients with benign FNA cytopathology, in 100% of AUS/FLUS, in 75% of FN, in 85.7% of SM. Allpatients who received radiotherapy had malignancy. In our study, the sensitivity of FNA was 80%, specificity 100%, positive predictive value 100%, negative predictive value 75%, and diagnostic value was 87.5%.
Conclusion: FNA results were highly compatible with thyroid histopathological examination. There were no clinical or sonographic findings that were related with thyroid cytopathological and histopathological examination.
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