Background: Children with Turner syndrome (TS) have a specific growth pattern that is quite different from that of healthy children. Many countries have population specific growth charts for TS.
Objective and hypotheses: Considering national and ethnic differences, we undertook this multicentered collaborative study to construct growth charts and reference values for height, weight, and BMI from birth to adulthood for spontaneous growth of Turkish girls with TS.
Method: Cross-sectional height and weight data of 842 patients with TS, younger than 18 years of age and before starting any therapy were evaluated. Data were processed to calculate 3th, 10th, 25th, 50th, 75th, 90th, and 97th percentile values for defined ages and to construct growth curves for height for age, weight-for-age and BMI-for-age for girls with TS.
Results: The growth pattern of TS girls in this series resembled the growth pattern of TS girls in other reports but there were differences in height between our series and the others. Mean birth length values were shorter than that of the normal population and deteriorated by age. While height was under −2 S.D. at 34 years of age, it gradually worsened and reached approximately −4 S.D. at about 12 years of age with lack of pubertal peak. The increase in BMI in TS girls especially between 2 and 6 years of age was noteworthy.
Conclusion: This study provide disease-specific growth charts for Turkish girls with TS. These disease specific national growth charts will improve the evaluation and management of growth promoting therapeutic agents in TS.
01 Oct 2015 - 03 Oct 2015