ESPE Abstracts (2015) 84 P-3-608

A Prospective Evaluation of Anthropometric and Metabolic Profile Premature Adrenarche Patients

Gülcan Seymen Karabuluta, Murat Imalb, Filiz Mine Çizmecioğlua & Sukru Hatuna


aKocaeli University Pediatric Endocrinology, Kocaeli, Turkey; bKocaeli University Pediatrics, Kocaeli, Turkey


Background: Premature adrenarche (PA) is defined as the appearance of pubic and/or axillary hair before 8 years in girls and 9 years in boys.

Objective and hypotheses: We aimed to evaluate the anthropometric measures, hormonal values of children with PA at time of diagnosis, distinguishing the patients with late onset congenital adrenal hyperplasia and to analyse the components of insulin resistance, obesity, hyperlipidemia, metabolic syndrome, menstrual irregularity, hirsutism and polycystic ovary syndrome (PCOS) in PA patients older than 10 years of age.

Method: The study included 101 girls seen with PA, in Kocaeli University Pediatric Endocrinology Clinic, until May 2014. Retrospective data of the patients was recorded from department database. The 47 patients older than 10 years of age were invited to hospital for re-evaluation. Routine physical examination, height, weight, blood pressure, waist circumference, 12-h fasting serum lipid levels, fasting glucose and insulin levels, oral glucose tolerance test, serum FSH,LH, DHEAS, total testosterone, 17-OH progesterone and pelvic ultrasonography were performed.

Results: Mean age at diagnosis was 7.82±1.1 years and mean age ot onset of symptoms was 6.73±0.91 years. Small for gestational age (SGA) birth was detected in 9.4% and late onset congenital adrenal hyperplasia in % 4. BMI was >1 SDS in 25% and bone age was advanced 35,6% of patients at time of diagnosis. Idiopathic PA (DHEAS <40 μg/dl) was 15%, typical PA (40–130 μg/dl) was 68% and exaggerated PA (130–180 mcg/dl) was 17% of patients. In children older than 10 years (prospective analysis), body mass index was >1 SDS in 19% and PCOS 27%. Hirsutism and PCOS were detected in 66% and biochemical hyperandrogenemia in all patients with history of SGA. Insulin resistance was detected in % 48.9 of patients and there was no significant difference between exaggerated adrenarche and isolated adrenarche groups due obesity, insulin resistance and PCOS.

Conclusion: PA seems to be a benign condition but leads to insulin resistance, hirsutism and PCOS, especially in patients with history of SGA.

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