Background: Triglyceride (TG)/HDL ratio has recently been considered a index of cardio-metabolic risk in healthy and obese subjects. Diet, lifestyle indexes, anthropometric parameters, and metabolic control are the variables with possible influence on belonging to a certain cardio-metabolic risk group.
Objective and hypotheses: To identify whether HbA1c per se has an influence on TG/HDL and to study other possible variables influencing the ratio.
Method: We evaluated 85 adolescents with type 1 diabetes (T1D). Inclusion criteria were age range 1219.9 years and T1D with at least 2-year duration. All patients underwent clinical examination and measurement of HbA1c and lipid profile, as well as filled-in the KIDMED questionnaire investigating Mediterranean diet quality index and a questionnaire on socio-economic and lifestyle indexes. The patients were subdivided according to Di Bonito et al. TG/HDL ratio tertiles (Diabetes Care 2012). The KruskalWallis (a) and χ2 (b) tests were applied.
Results: The Table 1 shows mean±S.D. values of variables significantly different among TG/HDL ratio classes. Age, waist/height ratio, mediterranean diet adherence, socioeconomic, and lifestyle parameters were not significantly different among the three groups. A stepwise multinomial logit model identified HbA1c as the parameter with the highest independent influence on belonging to the highest cardio-metabolic risk group (P=0.002), followed by SBP (P=0.034), while BMI and waist/height ratio disappeared after SBP entered the model.
|TG/HDL ratio||<1.2 (n=53)||≥1.2 and <2.0 (n=23)||≥2.0 (n=9)||P value|
Conclusion: In our group of adolescents with T1D, showing a fair level of adherence to Mediterranean diet and on average a correct lifestyle, HbA1c, and male sex were the major determinant of belonging to a low cardio-metabolic risk group.
01 - 03 Oct 2015
European Society for Paediatric Endocrinology