Background: Patients with type 1 diabetes (T1D) are at higher risk for developing coexisting autoimmune diseases.
Objective and hypotheses: To evaluate thyroid and celiac disease prevalence in children with T1D in Lithuanian paediatric population.
Method: 777 patients (49.7% males) <18yrs with T1D, covering all T1D pediatric Lithuanian population, were examined. Serum free thyroxine (FT4), thyrotropin (TSH), antithyroid peroxidase (ATPO) and tissue transglutaminase antibodies (tTG-A) were measured.
Results: Mean age of patients was 12.1±4.4 years (04 years 7.9%, 59 years 23.4%, 1014 years 36.9%, 1518 years 31.8%). Mean duration of T1D was 3.9±3.9 years, in 68.1% duration of disease was <5 years. The average level of HbA1c was 8.75±2.22%. 33.7% of children had HbA1c <7.5%. Thyroid dysfunction was detected in 17.6% of cases. Hypothyroidism was evident in 0.4%, subclinical hypothyroidism in 16.6%, hyperthyroidism in 0.6% of cases. Thyroid dysfunction was significantly more prevalent in females (P=0.053). ATPO were positive in 12% of cases. There was a significant association between positive ATPO and thyroid dysfunction (r=−0.165, P<0.001). No significant associations between thyroid dysfunction and metabolic control were found. Positive tTG-A were found in 4%. No significant correlations between positive tTG-A and HbA1c or duration of T1D were found (P=0.947 and P=0.062, respectively).
Conclusion: Thyroid dysfunction was more common in females and in patients with positive ATPO antibodies. The prevalence of positive tTG-A in Lithuanian children with T1D is similar to data from most other countries.
01 - 03 Oct 2015
European Society for Paediatric Endocrinology