ESPE Abstracts (2015) 84 P-3-754

Thyroid Function and Prevalence of Celiac Disease in Children with T1D in Lithuanian Pediatric Population

Ingrida Stankutea, Rimante Dobrovolskienea, Edita Jasinskienea, Giedre Mockevicienea, Brone Urbonaitea, Dalia Marciulionytea, Nijole Jurgevicienea & Valerie Schwitzgebelb

aInstitute of Endocrinology, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania; bChildren’s University Hospital, Pediatric Endocrine and Diabetes Unit, Geneva, Switzerland

Background: Patients with type 1 diabetes (T1D) are at higher risk for developing coexisting autoimmune diseases.

Objective and hypotheses: To evaluate thyroid and celiac disease prevalence in children with T1D in Lithuanian paediatric population.

Method: 777 patients (49.7% males) <18yrs with T1D, covering all T1D pediatric Lithuanian population, were examined. Serum free thyroxine (FT4), thyrotropin (TSH), antithyroid peroxidase (ATPO) and tissue transglutaminase antibodies (tTG-A) were measured.

Results: Mean age of patients was 12.1±4.4 years (0–4 years 7.9%, 5–9 years 23.4%, 10–14 years 36.9%, 15–18 years 31.8%). Mean duration of T1D was 3.9±3.9 years, in 68.1% duration of disease was <5 years. The average level of HbA1c was 8.75±2.22%. 33.7% of children had HbA1c <7.5%. Thyroid dysfunction was detected in 17.6% of cases. Hypothyroidism was evident in 0.4%, subclinical hypothyroidism – in 16.6%, hyperthyroidism – in 0.6% of cases. Thyroid dysfunction was significantly more prevalent in females (P=0.053). ATPO were positive in 12% of cases. There was a significant association between positive ATPO and thyroid dysfunction (r=−0.165, P<0.001). No significant associations between thyroid dysfunction and metabolic control were found. Positive tTG-A were found in 4%. No significant correlations between positive tTG-A and HbA1c or duration of T1D were found (P=0.947 and P=0.062, respectively).

Conclusion: Thyroid dysfunction was more common in females and in patients with positive ATPO antibodies. The prevalence of positive tTG-A in Lithuanian children with T1D is similar to data from most other countries.