ESPE Abstracts (2015) 84 P-3-920

Is the Insulin Secretion in Pancreatic Beta Cells Related with IGF-1/IGFBP-1 Axis in Korean Children?

Min Sun Kim & Dae-Yeol Lee

Pediatrics, Chonbuk National University Medical School, Jeonju-si, Republic of Korea

Background: The IGF system is involved in the development of metabolic and cardiovascular disease. This study aimed to investigate the association of insulin-like growth factor-1 (IGF1), IGF-binding protein-1 (IGFBP1) and IGFBP3 with insulin resistance and type 2 diabetes in children.

Methods: We included 36 children aged 10 to 16 years without known diabetes, medication, chronic disease. They were classified into three groups according to the results of oral glucose tolerance test and other clinical/laboratory findings. We performed anthropometric measurement and laboratory tests. The fasting levels of serum IGF-1, IGFBP-1 and IGFBP-3 were measured.

Results: i) Serum IGF1, IGFBP3 and IGF1/IGFBP1 molar ratio levels were significantly higher in glucose intolerance group. Serum IGF1 (r=−0.396, P=0.023) and IGFBP3 (r=−0.628, P<0.001) had negative correlation with IGFBP1. ii) Serum IGFBP1 was negatively correlated with age, BMI, systolic blood pressure, serum c-peptide, insulin, and HOMA-IR. And serum IGF1/IGFBP1 was significantly related with serum c-peptide, insulin and HOMA-IR. iii) Serum IGFBP1 had no correlation with fasting plasma glucose level, lipid profile, apoprotein A/B and HbA1c. It was not different between normal glucose tolerance group and glucose intolerance group. iv) In normal glucose tolerance group, serum IGFBP1 and IGF1/IGFBP3 was no significantly different between obese and non-obese groups. But IGFBP1 had negatively associated with age, BMI, systolic blood pressure, serum c-peptide, IGFBP3 and HOMA-IR.

Conclusion: Serum IGF1/IGFBP1 molar ratio was significantly elevated in Korean children with glucose intolerance sate and especially, serum IGFBP1 correlated with serum c-peptide. These findings suggest that IGFBP1 may related glycemic control and insulin secretion in children.

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