ESPE Abstracts (2015) 84 P-3-926

ESPE2015 Poster Category 3 GH & IGF (68 abstracts)

Usefulness of Priming with Gonadal Steroids Prior to GH Stimulation with Clonidine in the Evaluation of the GH Status of Short Children

Gulnara Rakhimova & Kamil Gilyazetdinov


Centre for the Scientific Study of Endocrinology, Tashkent, Uzbekistan

Aim: To determine the usefulness of priming with gonadal steroids prior to GH stimulation with clonidine in the evaluation of the GH status of short children.

Method: 21 males were studied, with a mean chronological age of 13.2±1.5 years (range 11–16 years), mean bone age 11.0±1.4 years, Tanner stage 1–2, with height 135.8±7.4 cm (Ht-SDS −2.8±0.5), and an inadequate response to an initial GH stimulation test with clonidine (peak GH<10 ng/ml). A second stimulation test with clonidine was performed in the same patients after gonadal steroid priming: 50 mg i.m. testosterone propionate daily for 3 days.

Results: 15 of 21 children (71%) increased their GH response to a level of >10 ng/ml following priming with gonadal steroids. Mean peak GH after priming was 11.32±5.6 ng/ml compared to a peak GH level of 3.9±2.8 ng/ml prior to gonadal steroid priming (peak GH 14.45±2.0 ng/ml in the responders vs 6.2±2.4 ng/ml in the non-responders).

Conclusion: Priming with gonadal steroids significantly improves GH secretion following GH stimulation with clonidine and diminishes the possibility of a false diagnosis of GH deficiency.

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