ESPE Abstracts (2015) 84 P-3-949

Plexiform Neurofibroma and Demielinisant Lesions in a Patient with GH Deficiency Treated with rGH

Luminita-Nicoleta Cimaa,b, Alice Albub,c, Simona Ficab,c & Carmen Gabriela Barbub,c

aPOSDRU/159/1.5/S/141531, Victor Babes Institute, Bucharest, Romania; b‘Carol Davila’ University of Medicine and Pharmacy, Bucharest, Romania; cDepartment of Endocrinology, Elias Hospital, Bucharest, Romania

Case report: A 13-year old boy treated with rGH for short stature due to isolated GH deficiency was submitted in our clinic in June 2014 for regular follow-up. From his medical history we note that he was diagnosed with GH deficiency in 2009 (−4.5 S.D.) and started treatment with rGH 0.035 mg/kgc per day since February 2009. The physical exam showed H=149.9 cm (−0.74 S.D.), 39 kg, Tanner P3G3 and a subcutaneous left paravertebral tumour in the toracal region reported to be painful by the patient. The tumour had hard consistency, was mobile and had no sign of inflammation. A spinal MRI was performed that showed a left paramedian toracal tumour located from T7 to T9 with extension in the left VIIIth foramen that raised the suspicion for a toracal neurofibroma with intra and extraforamen extension. He was sent to surgery and the biopsy revealed a plexiform neurofibroma. In October 2014 (4 months later), a spinal MRI was performed that showed no signs of restant tumour or relapse. Taking into account the patient’s family complaint of child’s poor scholar performance and memory loss, a cerebral MRI was done revealing some demielinisant supratentorial lesions; consequently, the patient is currently under evaluation in the paediatric neurology department.

Particularity: In this case, a keypoint resides in the fact that the tumour was discovered early due to the periodic follow-up for GH therapy but another issue might be the continuance of the GH-therapy.

Funding: This paper is partly supported by the Sectorial Operational Programme Human Resources Development (SOPHRD), financed by the European Social Fund and the Romanian Government under the contract number POSDRU 141531.

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