Background: Early menarche may be associated with diabetes, metabolic syndrome, cardiovascular disease and oligomenorrhoea in adults. While the state of metabolism and gonadal axis of early menarche girls and girls who treated with Gonadotropin-releasing hormone analogues (GnRHa) during puberty was not so clear.
Objective and hypotheses: We assessed in a retrospective unicentre study the state of metabolism and gonadal axis of early menarche girls and girls who treated with GnRHa during their puberty.
Method: 39 early menarche girls and 58 girls who had treated with GnRHa were enrolled in our study and 19 normal menarche girls were enrolled as control group. All of them were 2 years within puberty. Data were collected in height, weight, gonadal hormone, blood glucose, insulin, blood lipid, leptin, adiponectin and the size of uterus and ovary.
Results: Both BMI S.D.s for chronological age (CA) and for bone age (BA) of early menarche girls were significantly higher than normal menarche girls (P<0.05). The ratio of insulin resistance in early menarche girls (20.5%) was also significantly higher than normal girls (0%). No significant difference in lipid metabolism and gonadal axis between two groups. In girls treated with GnRHa, BMI S.D.s, insulin, HOMA-IR and the ratio of insulin resistance (20.7%) were all significantly higher than normal group (P<0.05). Meanwhile, DHEAS, androstenedione and testosterone of GnRHa treated girls were significantly higher than early menache girls, and DHEAS was higher than normal girls. The size of uterus in treated group was larger than the other two groups.
Conclusion: Early menarche and GnRHa treatment may take negative effect to BMI and glucose metabolism. Androgen was higher in GnRHa treated group. Therefore, suggestion was that BMI, insulin, blood glucose and androgen should be monitored in early menarche girls and girls treated with GnRHa.
01 - 03 Oct 2015
European Society for Paediatric Endocrinology