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55th Annual ESPE

Paris, France
10 Sep 2016 - 12 Sep 2016

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Paris, France: 10-12 September 2016 Further information

Free Communications

Perinatal Endocrinology

hrp0086fc10.1 | Perinatal Endocrinology | ESPE2016

CYP11B1 Deficiency in Very Preterms: Evidence for an Adrenal Cortex Zone-Specific and Developmental-Dependent Maturation

Travers Simon , Martinerie Laetitia , Boileau Pascal , Lombes Marc , Pussard Eric

Background: Unlike term neonates, known to exhibit a physiological pseudohypoaldosteronism, very preterms (VPT) display a high sodium waste at birth with partial aldosterone deficiency. This context, combined with a low aldosterone/renin ratio is highly suggestive of a defect in mineralocorticoid biosynthesis.Objectives and hypotheses: To investigate mineralocorticoid and glucocorticoid pathways in newborns, and to clarify the impact of prematurity upon ...

hrp0086fc10.2 | Perinatal Endocrinology | ESPE2016

Liver UPR and Metabolic Consequences in an Animal Model of Intrauterine Growth Retardation (IUGR)

Deodati Annalisa , Argemi JosepMaria , Puglianiello Antonella , Germani Daniela , Ferrero Roberto , Aragon Tomas , Cianfarani Stefano

Background: Endoplasmic reticulum (ER) is the site where proteins are folded in the cell. Metabolic stress alters ER homeostasis and activates the unfolded protein response (UPR), which contributes to the development of insulin resistance and metabolic syndrome.Objective and hypotheses: To longitudinally evaluate liver UPR and its functional consequences in an animal model of IUGR followed from birth to adulthood.Method: On day 19 ...

hrp0086fc10.3 | Perinatal Endocrinology | ESPE2016

Pharmacokinetics of Long Acting Somatostatin Analogue (Lanreotide) Therapy in Hyperinsulinaemic Hypoglycaemia (HH) and Understanding its Molecular Action via Somatostatin Receptors by Immunohistochemistry

Shah Pratik , Rahman Sofia , McElroy Sharon , Gilbert Clare , Morgan Kate , Hinchey Louise , Guemes Maria , Alam Syeda , Senniappan Senthil , Button Roberta , Margetts Rebecca , Levy Hannah , Santacreu Emma Bascompta , Marti Carles Morte , Lezcano Carles Celma , Amin Rakesh , Hussain Khalid

Background: Diazoxide and octreotide are first and second-line of treatment for HH respectively. Long-acting somatostatin analogue (Lanreotide, LA) has been used in adults with neuroendocrine conditions through its effect on somatostatin receptors 2 (SSTR2) and 5 (SSTR5).Objective and hypotheses: (i) To evaluate the efficacy, safety and pharmacokinetics of LA therapy in children with HH. (ii) To determine somatostatin receptor expression on pancreatic al...

hrp0086fc10.4 | Perinatal Endocrinology | ESPE2016

In Utero and Postnatal Consequences of Psychological Maternal Stress have Different Effects On Longevity: Studies in World War 1 Orphans

Todd Nicolas , Valleron Alain-Jacques , Bougneres Pierre

Background: Early life stress (ELS) are known to have a deleterious impact on health, but their potential long-term consequences on mortality remain to be assessed. World War 1 (WW1) has caused major stress and bereavement to millions of European mothers.Objectives and hypotheses: To compare the effects of a maternal stress occurring during intra uterine or in postnatal life upon long-term mortality.Patients: Thanks to recently dig...

hrp0086fc10.5 | Perinatal Endocrinology | ESPE2016

Effects of Developmental Bisphenol A Exposure on Spermatozoal microRNA Expression

Fisher Benjamin , Sandovici Ionel , Braukmann Fabian , Frederiksen Hanne , Constancia Miguel , Miska Eric , Acerini Carlo

Background: Bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical, has been shown to exert transgenerational effects on adiposity, metabolism, and reproductive outcomes in rodents, indicating epigenetic inheritance. Recent studies of other environmental insults (stress and high-fat diet) have demonstrated a mechanistic role for spermatozoal microRNAs in the transgenerational transmission of acquired paternal traits.Objective and hypotheses: To as...

hrp0086fc10.6 | Perinatal Endocrinology | ESPE2016

Developmental Programming of Somatic Growth, Behavior and the Endocannabinoid System (ECS) by Variation of Early Postnatal Nutrition in a Cross-Fostering Mouse Model

Schreiner Felix , Ackermann Merle , Michalik Michael , Rother Eva , Bilkei-Gorzo Andras , Racz Ildiko , Dotsch Jorg , Zimmer Andreas , Woelfle Joachim

Background: Nutrient deprivation during early development has been associated with the predisposition to metabolic disorders in numerous epidemiological studies. Experiments with rodents also indicate a developmental plasticity of neuropsychological characteristics following alterations of early postnatal nutrition.Objective: Considering its interaction with metabolism and regulation of appetite and behavior, the endocannabinoid system (ECS) may represen...