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55th Annual ESPE

Paris, France
10 Sep 2016 - 12 Sep 2016

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Paris, France: 10-12 September 2016 Further information

Poster Presentations

Diabetes P1

hrp0086p1-p190 | Diabetes P1 | ESPE2016

The Association of HLA Class II, CTLA-4 and PTPN22 Genetic Polymorphisms and β-Cell Autoantibodies in Development of Type I Diabetes in Patients with Autoimmune Thyroid Disease

Putarek Natasa Rojnic , Grubic Zorana , Grcevic Danka , Kusec Vesna , Knezevic-Cuca Jadranka , Krnic Nevena , Uroic Anita Spehar , Baretic Maja , Dumic Miroslav

Background: Co-occurrence of type 1 diabetes (T1D) and autoimmune thyroid disease (AITD) denote variant of autoimmune polyglandular syndrome type 3 (APS3v). Thyroid autoimmunity in T1D was widely studied, but a few studies examined β-cell autoimmunity among AITD patients. Several susceptibility genes for APS3v have been identified: HLA class II, CTLA-4 and PTPN22 gene.Objective and hypotheses: To investigate β-cell autoimmunity and genetic poly...

hrp0086p1-p191 | Diabetes P1 | ESPE2016

Insulin Pump Does Not Allow a Better Control than Injections in Childhood Type 1 Diabetes (T1d) in the ISIS-Diab Cohort

Fur Sophie Le , Castell Anne Laure , Lucchini Philippe , Bougneres Pierre , Network ISIS-Diab

Background: The use of insulin pumps is rapidly spreading within the paediatric T1D community. A few small studies have promoted pump usage, while large registries have shown almost no advantage of this treatment.Objectives: Compare the results of treatment with insulin pump (‘Pump’) with insulin injections (‘Inj’) in a large cohort of children with T1D in field conditions.Patients: We studied 3137 children of t...

hrp0086p1-p192 | Diabetes P1 | ESPE2016

Diagnostic Features of Lipodystrophy in Children with Type 1 Diabetes

Chumak Svitlana , Budreiko Olena

Background: Insulin therapy by creating a subcutaneous depot remains an integral part of the treatment of diabetes in children. Places of insulin administration are restricted to certain parts of the body and the condition of subcutaneous fat affects the variability of glycaemia no less than quality of insulin. Formation of lipodystrophies (LD) causes glycaemia variability, difficulties in selection of insulin doses and achieving disease compensation.Obj...

hrp0086p1-p193 | Diabetes P1 | ESPE2016

Recombinant Human Insulin-Like Growth Factor 1 (rh IGF1) Treatment of a Case of Leprechaunism: A Two and a Half Year Follow-Up

Valle Aline , Lefevre Christine , Weill Jacques , Cartigny Maryse

Background: Leprechaunism, due to a mutation of both alleles of insulin receptor gene, is a most severe and precociously life-threatening condition, difficult to treat.Objective and hypotheses: In leprechaunism rhIGF1 may replace insulin through I the insulin-like metabolic properties of its own receptor.Method: rh IGF1 was continuously subcutaneously administered through a.pump from the age of four months and adjusted according to...

hrp0086p1-p194 | Diabetes P1 | ESPE2016

Longitudinal Monitoring of Pediatric Insulin Treatment in Germany and Austria: Age-Dependent Analysis of 63 967 Children and Adolescents with Type 1 Diabetes from the DPV Registry

Bohn Barbara , Karges Beate , Vogel Christian , Otto Klaus-Peter , Marg Wolfgang , Hofer Sabine E , Frohlich-Reiterer Elke , Holder Martin , Plamper Michaela , Wabitsch Martin , Kerner Wolfgang , Holl Reinhard W

Background: Depending on age, needs and preferences in insulin therapy strongly differ between children and adolescents with type 1 diabetes (T1D).Objective and hypotheses: To analyse trends in insulin regimen and type of insulin used over the last two decades in three age-groups of pediatric patients with T1D from Germany/Austria.Method: 63 967 subjects (<18 year of age) with T1D documented between 1995 and 2014 from the &#145...

hrp0086p1-p195 | Diabetes P1 | ESPE2016

Two Patients with HADH (SCHAD) Hyperinsulinism without Detectable 3-Hydroxybutyrylcarnitine/3-Hydroxyglutarate

Weiss Susanne , Bachmann Nadine , Mayatepek Ertan , Meissner Thomas , Bergmann Carsten , Kummer Sebastian

Background: Congenital hyperinsulinism of infancy (CHI) is the most common cause for persisting hypoglycaemia in infancy. Genetic causes are mutations in ABCC8 or KCNJ11 (coding for K+ATP-channel subunits), less frequently mutations in GCK or GLUD1. Further genetic examinations are usually performed only if phenotypic aspects point to other specific genes, such as the rare short chain 3-hydroxylacyl-CoA dehydrogenase (<...

hrp0086p1-p196 | Diabetes P1 | ESPE2016

Development of Type 1 Diabetes in a Child with Inherited CD59 Deficiency Treated with Eculizumab

Koca Serkan Bilge , Ozon Alev , Alikasifoglu Ayfer , Haliloglu Goknur , Topaloglu Haluk

Background: CD59 is a complement regulatory protein which inhibits membrane attack complex protecting self-cells from complement-mediated damage. Recent evidence suggests CD59 may suppress T cell activation via a complement-independent mechanism. Other than an immune regulator, CD59 is shown to regulate glucose stimulated insulin secretion. Herein we report a patient with inherited CD59 deficiency who developed type 1 diabetes.Case: 11 year-old girl was ...

hrp0086p1-p197 | Diabetes P1 | ESPE2016

Diagnosis of Non-Autoimmune Paediatric Diabetes by Targeted Next Generation Sequencing (NGS): Findings in Two Families with Rare Mono- and Digenic forms of Diabetes

Poidvin Amelie , Donath Xavier , Saint-Martin Cecile , Loison Sylvie , Carel Jean-Claude , Bellanne-Chantelot Christine , Tubiana-Rufi Nadia

Background: Nearly 10% of paediatric onset diabetes are auto-antibodies negative. Among them monogenic diabetes are frequently under-diagnosed. The major increase in the prevalence of childhood obesity is misleading with a risk of confusion between type 2 diabetes (T2D) and monogenic causes of diabetes.Objective and hypotheses: To report on two informative families with negative auto-antibodies childhood-onset diabetes cases.Method...

hrp0086p1-p198 | Diabetes P1 | ESPE2016

Neonatal Siabetes, Gallbladder Agenesis and Cholestatic Giant Cell Hepatitis: A Novel Homozygote Mutation in PDX-1 Gene

Ozturk Mehmet Adnan , Ozdemir Ahmet , Gul Ulku , Hatipoglu Nihal , Korkut Sabriye , Ceylan Mahir , Kurtoglu Selim

Background: It is known that PDX-1 gene mutation is related to neonatal diabetes, pancreas agenesis and intrauterine growth retardation. Here the aim was to present a novel defined mutation in PDX-1 gene in case born with IUGR, diagnosed with neonatal diabetes and in which exocrine pancreas deficiency and gallbladder agenesis were detected.Case presentation: Blood glucose was measured as 185 mg/dl in the first hour after birth and insulin infusion was gi...

hrp0086p1-p199 | Diabetes P1 | ESPE2016

Anthropometry and Glucose Homeostasis in a Patient with Donohue Syndrome (Homozygous Insulin Receptor Mutation): Effect of Continuous s.c. rIGF-I Therapy

Plamper Michaela , Schreiner Felix , Gohlke Bettina , Wolfle Joachim

Background: Donohue syndrome (DS) is caused by autosomal-recessive loss of function mutations of the insulin receptor gene. DS is associated with diabetes mellitus unresponsive to conventional insulin therapy due to severe insulin resistance. Patients exhibit IUGR and postnatal failure to thrive. They develop a characteristic facies, hypertrichosis and acanthosis nigricans. Most patients die within the first two years of life because of respiratory infections. To date, no caus...

hrp0086p1-p200 | Diabetes P1 | ESPE2016

Driving Paediatric Diabetes Care Forward in the UK: Improvements in Outcomes in the North West Following National Initiatives

Moore Helen S , Carson Margot E , Maiden Jonathan , Ng Sze May

Background: Type 1 diabetes mellitus (T1DM) continues to pose serious health risks with devastating long-term complications. UK management and control of T1DM in children and young people (CYP) remains amongst the poorest in Europe and significant variations in diabetes health outcomes are evident. In 2012–13 a Best Practice Tariff (BPT) for paediatric diabetes care was introduced and a National Peer Review Quality Assurance programme (DQuINS) developed. Both were develop...

hrp0086p1-p201 | Diabetes P1 | ESPE2016

Non-Surgical Treatment of Diazoxide-Resistant of Early Diffuse Hyperinsulinism Using Long-Acting Octreotide, A Somaatostatin Analog: Follow-Up of Six Cases

Mention Karine , El Habbas Maya , Sechter Claire , Cartigny Maryse , Dobbelaere Dries

Background: Early diffuse hyperinsulinism represents a life- and brain-threatening condition. Besides enteral or parenteral additional supply, diazoxide represents the first line treatment. For diazoxide-resistant (DREDHI) patients, ablative surgery exposes to severe local complications, exocrine pancreas insufficiency and diabetes or residual hypoglycaemia.Objective and hypotheses: To evaluate the pros and cons of non-surgical treatment of DREDHI.<p...

hrp0086p1-p202 | Diabetes P1 | ESPE2016

Screening for Autonomic Neuropathy in Children and Adolescents with Type 1 Diabetes Mellitus

Kallinikou Dimitra , Tsentidis Charalampos , Louraki Maria , Papathanasiou Asteroula , Kanaka-Gantenbein Christina , Karavanaki Kyriaki

Background: Diabetic neuropathy is among the least recognized complications of diabetes, despite its significant negative impact on survival and quality of life. Characteristic neuronal alterations may occur subclinically early in the course of the disease, even in childhood. The prevalence of subclinical neuropathy in paediatric population ranges from 7.9 – 19% in different studies.Objective and hypotheses: Our objective was to study the prevalence...

hrp0086p1-p203 | Diabetes P1 | ESPE2016

Diabetes Mellitus Caused by Bone Marrow Transplantation and Total Body Irradiation – Experience from a Regional Single Centre

Candler Toby , Wei Christina , Bradley Karin , Cox Rachel , Elson Ruth , Stevens Michael , Crowne Elizabeth

Background: Diabetes is a recognised long term sequelae in childhood cancer survivors following bone marrow transplantation and total body irradiation (BMT/TBI), due to a combination of insulin deficiency and resistance.Aim: To characterise presentation, treatment and clinical course of diabetes in childhood leukaemia survivors post BMT/TBI.Method: A single centre retrospective case note review of diabetes post BMT/TBI identified f...

hrp0086p1-p204 | Diabetes P1 | ESPE2016

A Syndrome of Permanent Neonatal Diabetes Mellitus and Neurological Abnormalities due to a Novel Homozygous Missense c.449T>A (p.I150N) Mutation in NEUROD1 Gene

Hatipoglu Nihal , Demirbilek Huseyin , Gul Ulku , Tatli Zeynep Uzan , Flanagan Sarah , Ellard Sian , De Franco Elisa , Kurtoglu Selim

Neonatal diabetes mellitus (NDM) is a rare form of monogenic diabetes presenting in the first 6 months of life. NEUROD1 is a transcriptional factor involved in the development of endocrine pancreas. A few patients with maturity onset diabetes of the young (MODY) due to heterozygous NEUROD1 mutations and only two cases with permanent NDM (PNDM) associated to neurological disorders and cerebellar hypoplasia due to homozygous mutations in the NEUROD1 gene have been reported.<...

hrp0086p1-p205 | Diabetes P1 | ESPE2016

Are We Screening Appropriate Age Group for Early Diagnosis of Cystic Fibrosis Related Diabetes in UK?

Gangadharan Arundoss , Berry Claire , Watling Ruth , Kerr Sue , Southern Kevin , Senniappan Senthil

Background: Nutrition plays a pivotal role in long-term survival in cystic fibrosis (CF). Early insulin treatment for glucose intolerance promotes anabolism and stabilises lung function. However there is a variation in cystic fibrosis related diabetes (CFRD) screening across centres (recommended age for start of CFRD screening varies between 10 and 12 years as per CF trust, CFF & ISPAD guidelines).Aims: To assess if early screening of glycaemic statu...

hrp0086p1-p206 | Diabetes P1 | ESPE2016

When to Screen for Coeliac Disease in Children with Type 1 Diabetes Mellitus: The Controversy

Ajanaku Ayo , Gorst Thomas , Ajanaku Deji , Chizo Agwu Juliana

Background: Routine screening for Coeliac disease (CD) beyond the first year of diagnosis with Type 1 Diabetes Mellitus (T1DM) is controversial due to a paucity of high-quality evidence. The UK guidelines (NICE) only recommend screening at diagnosis with T1DM or if subsequently symptomatic; whereas the International Society for Paediatric and Adolescent Diabetes (ISPAD) recommends routine screening every 1 to 2 years.Objective and hypotheses: We hypothes...

hrp0086p1-p207 | Diabetes P1 | ESPE2016

Interrelation between ACE Gene I/D Polymorphism and Chronic Kidney Disease Severity in Uzbek Children and Adolescents with Type 1 Diabetes Mellitus

Rakhimova Gulnara , Sadykova Akida

Background: Generally, diabetic nephropathy onsets and progresses within 5–10 years after DM onset resulting in chronic kidney disease (CKD) causing death in every 4–5th patient with type I DM. Molecular-genetic studies of endogenous/genetic CKD risk factors are of high relevance in understanding of pathogenetic mechanisms underlying formation of nephrosclerosis, and in improvement of interventions.Objective and hypotheses: To assess renal func...

hrp0086p1-p208 | Diabetes P1 | ESPE2016

Improvement of Diabetic Screening System for School Children Achieved by Close Cooperation with a Local Government of Atsugi City

Saito Maki , Motoki Takanori , Ito Akira , Ito Takeru , Tajima Asako , Tajima Naoko , MIyata Ichiro

Background: In Japan, diabetic screening for school children using urinalysis has been performed to detect diabetes mellitus during childhood throughout the country. However, inadequate follow-up system after urinary screening caused several problems. The rate of participation in workup examination still remains less than 30%. Also, accurate annual incidences of children with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) detected by screening of urine glu...

hrp0086p1-p209 | Diabetes P1 | ESPE2016

Association between Hypothalamus–Pituitary Adrenal Axis Activity and Anxiety in Prepubertal Children with Type 1 Diabetes

Barat Pascal , Brossaud Julie , Bereron Aude , Corcuff Jean-Benoit , Moisan Marie-Pierre , Lacoste Aurelie , Vautier Vanessa , Savel Helene , Perez Paul

Background: Animal models of insulin-dependent diabetes show hyperactivity of hypothalamus–pituitary adrenal (HPA) axis, independently of hypoglycaemia. Few data exists regarding type 1 diabetes (T1D) in children.Objective: To describe HPA axis activity according to the anxiety levels in prepubertal T1D children.Method: Prepubertal T1D children and siblings of T1D children (controls) were included. State-Trait Anxiety Inventor...

hrp0086p1-p210 | Diabetes P1 | ESPE2016

Screening for Liver Disease in Children and Adolescents with Type 1 Diabetes Mellitus: A Cross-sectional Analysis

Kummer Sebastian , Klee Dirk , Kircheis Gerald , Friedt Michael , Schaper Joerg , Haussinger Dieter , Mayatepek Ertan , Meissner Thomas

Background: The liver is one of the most important organs in glucose metabolism and closely related to diabetes pathophysiology. Non-alcoholic fatty liver disease (NAFLD) is well known in type 2 diabetes mellitus (DM), but also adult patients with type 1 DM are at increased risk for NAFLD.Objective and hypotheses: Here, we studied the prevalence of liver disease in a representative number of children and adolescents with type 1 DM in Germany.<p class...

hrp0086p1-p211 | Diabetes P1 | ESPE2016

Exploration of Social Network, Social Integration, and Socioeconomic Status in Families with Young Children with Type 1 Diabetes

Heinrich Michaela , Galler Angela

Background: Psychosocial factors are important for patients with chronic diseases such as type 1 diabetes. Lack of social network and poor social support are risk factors that affect morbidity. Little is known about social network and social integration of families with children with type 1 diabetes.Objective and hypotheses: Aim was to explore the social network of families with young children with type 1 diabetes and to examine associations between indi...

hrp0086p1-p212 | Diabetes P1 | ESPE2016

Permanent Neonatal Diabetes Mellitus due to a Novel Homozygous GCK Mutation in a Premature Baby with IUGR and Its Management

Braha Nirit , De Franco Elisa , Dawes Adam , Sharples Kate , Moodambail Abdul , Hughes Claire , Ellard Sian , Gevers Evelien

Background: Glucokinase (GCK) acts as the glucose sensor of β-islet cells, regulating insulin secretion in response to changing glucose concentrations. Homozygous GCK mutations are a rare cause of permanent neonatal diabetes. Heterozygous mutations lead to GCK MODY, causing mild hyperglycaemia, not usually requiring treatment.Case: The index case was born to consanguineous parents at 36+2 weeks gestation, weighing 1610 g (0.4th centile). Hy...

hrp0086p1-p213 | Diabetes P1 | ESPE2016

The Impact of Diet on Insulin Dynamics over a 2-Year Period in Children with a Family History of Obesity

Leclerc Lucas , Gray-Donald Katherine , Benedetti Andrea , Radji Sanyath , Henderson Melanie

Background: Despite extensive evidence in adults that lifestyle modification, including a healthy diet, may prevent the onset of type 2 diabetes, studies examining the impact of chronic dietary exposures on insulin dynamics in at-risk children are lacking.Objective and hypotheses: To assess how dietary intake predicts insulin sensitivity and secretion over a 2-year period in children with a family history of obesity.Method: Data st...

hrp0086p1-p214 | Diabetes P1 | ESPE2016

Analysis of Short-Term Efficacy of MiniMed 640G with SmartGuard in Pediatric Patients with Type 1 Diabetes

Villafuerte Beatriz , Martin-Frias Maria , Yelmo Rosa , Roldan Belen , Angeles Alvarez M. , Barrio Raquel

Background: Fear of hypoglycemia is a major constraint on achieving a good metabolic control in T1D. Sensor augmented insulin pump therapy with threshold-suspended features (MiniMed 640G-SG) might alleviate burden of hypoglucemia and improve outcomes.Objective and hypotheses: Evaluate the effectiveness of this system to prevent day and night hypoglycemia and its impact on HbA1c in a pediatric population with T1D.Method: Descriptive...

hrp0086p1-p215 | Diabetes P1 | ESPE2016

The Influence of ß-Cell Autoimmunity on Cystic Fibrosis Related Diabetes Mellitus – A DPV Registry Analysis

Wurm Michael , Prinz Nicole , Konrad Katja , Laubner Katharina , Kieninger Dorothee , Kapellen Thomas , Wiemann Dagobert , Schebek Martin , Lilienthal Eggert , Smaczny Christina , Witsch Michael , Bauer Maria , Holl Reinhard W.

Background: Knowledge on the role of diabetes antibodies in CF related diabetes mellitus (CFRD) is scarce.Objective and hypotheses: We aim to inquire the relevance of ß-cell autoimmunity in CFRD.Methods: The German/Austrian/Luxembourgian diabetes registry DPV was searched for CFRD patients. 878 individuals were analyzed by multivariable regression models.Results: 8.7% of patients with CFRD in our cohort ...

hrp0086p1-p216 | Diabetes P1 | ESPE2016

Thyroid and Islet Autoantibodies Predict Autoimmune Thyroid Disease Already at Diagnosis of Type 1 Diabetes

Jonsdottir Berglind , Larsson Christer , Carlsson Annelie , Forsander Gun , Anders Ivarsson Sten , Lernmark AEke , Ludvigsson Johnny , Marcus Claude , Samuelsson Ulf , Ortqvist Eva , Elding Larsson Helena

Background: Screening for autoimmune thyroid disease in children and adolescents with type 1 diabetes lacks consensus. Optimal screening methods should benefit the patients and reduce costs to healthcare.Objective and hypotheses: To, at diagnosis of type 1 diabetes, determine the predictive value of thyroid autoantibodies, thyroid function, islet autoantibodies, and HLA-DQ for autoimmune thyroid disease.Method: At diagnosis of type...

hrp0086p1-p217 | Diabetes P1 | ESPE2016

Hemolysis in a Girl with Type 1 Diabetes Mellitus and Glucose-6-Phosphate Dehydrogenase Deficiency

Hou Lele , Lin Shaofen , Liang Liyang , Meng Zhe , Zhang Lina , Liu Zulin

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a X-linked enzymopathy. Hemolysis during type 1 diabetes mellitus (T1DM) treatment in patients with G6PD deficiency has been reported, but the underlying pathogenesis is not fully clarified.Objective and hypotheses: We try to explore the association between the two diseases.Method: We report a girl in whom hemolysis occurred after diabetic ketoacidosis (DKA) treatme...

hrp0086p1-p218 | Diabetes P1 | ESPE2016

Clinical Characteristics and Molecular Analysis of Patients with Neonatal Diabetes

Yavas Abali Zehra , Bundak Ruveyde , Bas Firdevs , De Franco Elisa , Genens Mikayir , Poyrazoglu Sukran , Ellard Sian , Hattersley Andrew , Darendeliler Feyza

Background: Neonatal diabetes mellitus (NDM) is a form monogenic diabetes diagnosed under 6 month of age.Objective and hypotheses: To describe the clinical and molecular features of NDM patients in a Turkish cohort.Method: Fifteen patients (13M, 2F) with diabetes onset before 6 months of age were included in the study. Clinical and molecular data were evaluated retrospectively.Results: Mean age at diagnosis w...

hrp0086p1-p219 | Diabetes P1 | ESPE2016

Impact of Continuous Glucose Monitoring System on Therapy of Cystic Fibrosis Related Diabetes in Children and Young Adults

Todorovic Sladjana , Milenkovic Tatjana , Minic Predrag , Mitrovic Katarina , Sovtic Aleksandar , Rodic Milan , Vukovic Rade , Plavsic Ljiljana

Background: Cystic fibrosis related diabetes (CFRD) is one of the most common complications of CF. CFRD has great impact on progressive deterioration of lung function, poor growth and increased mortality. The need for early detection of disturbance in glucose metabolism was recognized long ago. Current recommendations include screening that begins at age of 10 by performing oral glucose tolerance test (OGTT) but it cannot reveal the initial glucose disturbances. Many centres a...

hrp0086p1-p220 | Diabetes P1 | ESPE2016

Effect of Allopurinol Versus Angiotensin Converting Enzyme Inhibitors in Decreasing Microalbuminuria in Type 1 Diabetic Patients

Elbarbary Nancy , El-Samahy Mona , Abo-El-Asrar Mohamed , Sallam Dina

Background: Diabetic nephropathy is a major microvascular complication of diabetes. It affects 25–35% of diabetic patients diagnosed under the age of 30 years. It is the leading cause of premature death in young diabetic patients.Objective and hypotheses: This study was primary designed to assess the short-term effect (6 months) of allopurinol treatment compared to angiotensin-converting enzyme inhibitor (ACEI) and placebo in type 1 diabetic patient...

hrp0086p1-p221 | Diabetes P1 | ESPE2016

Continuous Glucose Monitoring and Hypoglycemia Unawareness in Children and Adolescents with Type 1 Diabetes

Demir Gunay , Ozen Samim , Cetin Hafize , Darcan Sukran , Goksen Damla

Background: Seeking strict normoglycemia in type 1 diabetes mellitus increases the risk of hypoglycemia, exposing to hypoglycemia unawareness. Hypoglycemia unawareness (HU) is defined as the occurrence of hypoglycemic symptoms directly without autonomic symptoms. This study is designed to determine the incidence of HU in children and adolescents with continuous subcutaneous glucose monitoring system and to assess the effect of structured education to improve awareness.<p c...

hrp0086p1-p222 | Diabetes P1 | ESPE2016

Transient, Neonatal Hyperinsulinemic Hypoglycemia May be Monogenetic, Not Only Secondary to Fetal Life Events

Olesen Louise , Jacobsen Anne , Brusgaard Klaus , Christesen Henrik

Background: Congenital hyperinsulinism (CHI) is a rare, heterogeneous disease with a transient, recurrent or persistent course. Transient CHI (tCHI) is considered to be caused by non-genetic risk factors e.g. birth asphyxia and intrauterine growth restriction (IUGR), while persistent hyperinsulinism is known to be caused by mutations in at least nine genes: ABCC8, KCNJ11, GLUD1, GCK, HADH, SLC16A1, HNF4A, HNF1A and UCP2.Objective and hy...

hrp0086p1-p223 | Diabetes P1 | ESPE2016

The Relationship between the Serum Irisin Levels and the Metabolic Control in adolescents with Type 1 Diabetes

Yuksel Aysegul , Seymen Karabulut Gulcan , Baydemir Canan , Yesiltepe Mutlu Gul , Isgoren Serkan , Cekmen Mustafa , Hatun Sukru

Background: Irisin is an adipomyokine secreted by many tissues. Because it has known relationships with the energy metabolism and exercise, its relationships with obesity and type 2 diabetes (T2D) are being focused on. Its relationship with type 1 diabetes (T1D) is unknown.Objective and hypotheses: In this study, the relationships between the serum irisin level and the metabolic control were investigated in adolescents with T1D.Met...

hrp0086p1-p224 | Diabetes P1 | ESPE2016

Space-time Environmental Associations in Childhood Type 1 Diabetes (T1D). A Case-control Geographical Approach in the ISIS-Diab Cohort

Bougneres Pierre , Le Fur Sophie , Valtat Sophie , Valleron Alain-Jacques , ISIS-Diab Network Network

Background: T1D concordance in MZ twins being ~40%, non-heritable factors play a major causal role in this autoimmune disease. T1D has recently increased in young European children. Collecting prospective environmental data in a cohort of millions children-years starting soon after birth seems unpracticable. Retrospective case-control studies are an alternative, provided biased controls and recall bias can both be avoided.Objectives: To develop a ‘v...

hrp0086p1-p225 | Diabetes P1 | ESPE2016

Association Between Vascular Endothelial Markers and Carotid Intima-media Thickness in Children and Adolescents with Type 1 Diabetes Mellitus

Rostampour Noushin , Hashemi-Dehkordi Elham , Fekri Kiavash , Obodiat Mahdieh

Background: Type 1 diabetes mellitus (T1DM) is an important risk factor for cardiovascular events. Endothelial dysfunction and carotid intima-media thickness (CIMT) lead to increased cardiovascular complications. Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) are markers of early atherosclerosis and play a significant role in developing atherosclerosis. The general aim of the present study was to investigate...

hrp0086p1-p226 | Diabetes P1 | ESPE2016

Abstract unavailable....

hrp0086p1-p227 | Diabetes P1 | ESPE2016

Rising of Type 1 Diabetes Mellitus Incidence in Chilean Children Between 2006 and 2014

Garfias Carolina , Garcia Hernan , Ugarte Francisca , Martin Yonathan San , Bortzuski Arturo , Cerda Jaime

Background: T1DM incidence in children varies across regions and countries, showing a continue rise Worldwide.Objective and hypotheses: To determine the incidence of T1D in Chilean children under 20 years between 2006 and 2012.Method: We reviewed mandatory notifications of T1D (GES Program) in Chile’s public health system in population younger than 20 years between 2006 and 2014. Data were obtained from the Department of Infor...

hrp0086p1-p228 | Diabetes P1 | ESPE2016

Frequency and Risk Factors of Depression in Type 1 Diabetes in a Developing Country

Khater Doaa , Omar Heba

Background: Living with type 1 diabetes especially in developing countries can feel overwhelming for parents and children because constant vigilance is required for proper care with inadequacy of resources.Objectives and hypothesis: Our aim was to investigate the frequency of depressive symptoms in children and adolescents with type 1 diabetes and their association with demographic, diabetes-specific, and family-functioning risk factors.<p class="abs...

hrp0086p1-p229 | Diabetes P1 | ESPE2016

Phenotypic Variability of Identical Mutations in the ABCC8 Gene in Two Families

Rozenkova Klara , Zapletalova Jirina , Dusatkova Lenka , Dusatkova Petra , Obermannova Barbora , Pruhova Stepanka , Lebl Jan , Sumnik Zdenek

Background: Mutations in the SUR1 subunit of the KATP channel encoded by the ABCC8 gene can result in diverse phenotypes ranging from Transient Neonatal Diabetes (TNDM) to type 2 diabetes in adulthood. These patients may benefit from sulphonylurea treatment.Objective and hypotheses: To describe the course of diabetes in two families with ABCC8 gene mutations and to assess the effect of sulphonylurea treatment.<p class="ab...

hrp0086p1-p230 | Diabetes P1 | ESPE2016

Growth and Glucose Metabolism after Allogenic Bone Marrow Transplantation for Thalassemia Major

Lao Wenqin , Liang Liyang , Meng Zhe , Ou Hui , Hou Lele

Background: Growth failure and abnormal plasma glucose level are common in patients with thalassemia major (TM), which are usually due to iron overload after repeated blood transfusion. Patients after successful bone marrow transplantation (BMT) will be free from further blood transfusion and thus spared from complications of iron overload. This study aimed at determining the incidence of abnormal glucose level in TM patients and studying the height difference between the TM p...

hrp0086p1-p231 | Diabetes P1 | ESPE2016

A Rare Form of Insulin Resistance with Pseudoacromegaly

Stone Stephen , Wambach Jennifer , Cole F. Sessions , Wegner Daniel , Urano Fumihiko

Background: Insulin resistance occurs in a variety of common endocrine disorders including obesity, type 2 diabetes, polycystic ovarian syndrome, and metabolic syndrome. Additionally, rare syndromes exist that result in extreme insulin resistance. These conditions help contribute to our knowledge of the mechanisms of insulin signalling and resistance.Objective and hypotheses: We report a case of a 12 year old female presenting to endocrinology clinic for...

hrp0086p1-p232 | Diabetes P1 | ESPE2016

Extrahepatic Biliary Atresia in Combination with Toxic Cholestasis Due to Glibenclamide in a Case of Neonatal Diabetes

Kapellen Thomas , Flemming Gunter , Bartelt Heike , Wachowiak Robin , Kiess Wieland

Background: More than 20 gene loci are known to cause monogenic neonatal diabetes today. A definite mutation can be found in 65–70% of all cases. Mutations in the ATP sensitive potassium channel can frequently be treated by sulfonylurea. Glibenclamide is on of the drugs known to inhibit the bile salt export pump (BSEP). However most drug induced cholestasis cases are reported in adults.Objective and hypotheses: Glibenclamide is used frequently to tr...

hrp0086p1-p233 | Diabetes P1 | ESPE2016

Higher-Than-Conventional Subcutaneous Regular Insulin Doses Following Diabetic Ketoacidosis are Associated with Better Short-term Glycemic Control

Bag Ozlem , Tunc Selma , Nalbantoglu Ozlem , Ecevit Cigdem , Ozturk Aysel , Ozkan Behzat , Demir Korcan

Background: While some guidelines recommend 0.5–1.0 units/kg per day of subcutaneous insulin following resolution of diabetic ketoacidosis (DKA), up to 2 units/kg/day are used in various centers.Objective and hypotheses: To test the hypothesis that higher initial insulin doses would be more efficient during first 48 h of subcutaneous insulin therapy after DKA in cases with new-onset type 1 diabetes.Method: Records of patients ...

hrp0086p1-p234 | Diabetes P1 | ESPE2016

Assessment of Selected Carbohydrate Parameters in Children Exposed to Gestational Diabetes in utero

Wilk Malgorzata , Horodnicka-Jozwa Anita , Moleda Piotr , Petriczko Elzbieta , Safranow Krzysztof , Chojnacka Hanna , Gawrych Elzbieta , Walczak Alicja , Walczak Mieczyslaw

Background: Children exposed to gestational diabetes mellitus (GDM) in utero have higher risk of development of glucose intolerance and diabetes mellitus.Objective and hypotheses: The study was undertaken to assess the selected carbohydrate parameters in children exposed to gestational diabetes in utero.Method: 50 children exposed to gestational diabetes were compared with 46 control subjects. Anthropometric parameters of a newborn...

hrp0086p1-p235 | Diabetes P1 | ESPE2016

The Genetic Causes and Phenotypic Characteristics of Egyptian Patients with Neonatal Diabetes Mellitus

Elkaffas Rasha , Musa Noha , Franco Elisa De , Madani Hanan A , Shaalan Yomna , El-Kaffas Rania M.H. , Hassan Mona , Hafez Mona , Kholi Badawy El , Flanagan Sarah E , Ellard Sian , Hussain Khalid

Background: Neonatal Diabetes Mellitus (NDM) is a rare form of monogenic diabetes that typically presents during the first 6 months of life. Its prevalence is about 1:100 000 live births; however it may rise up to 1:29 000 in highly consanguineous populations. Mutations in 22 different genes are reported; with the most common cause being potassium channel subunit gene (KCNJ11/ABCC8) mutations. However, causative mutations among consanguineous populations seem to diffe...

hrp0086p1-p236 | Diabetes P1 | ESPE2016

Does Adherence to a High HbA1c Policy Improve Outcomes in a Paediatric Diabetic Clinic Population?

Beckett Rachel , Abid Noina

Background: Poor glycaemic control, indicated by a high HbA1c level, increases the risk of developing complications of type 1 diabetes. It is, therefore important to reduce HbA1c levels aiming for the new target outlined by NICE (2015) of 48 mmol/mol. To try and improve HbA1c levels in patients attending a large urban diabetic clinic a policy was developed, targeting patients with an HbA1c level of 64 mmol/mol or higher.Objective and hypotheses: To asses...

hrp0086p1-p237 | Diabetes P1 | ESPE2016

The Prevalence of Diabetic Ketoacidosis in Children with New-Onset Type 1 Diabetes Mellitus

Niechcial Elzbieta , Gertig-Kolasa Anna , Krzysko-Pieczka Izabela , Skowronska Bogda , Stankiewicz Witold , Michalak Michal , Fichna Piotr

Background: Children at type 1 diabetes (T1DM) diagnosis can develop ketoacidosis (DKA), a life-threatening condition, which is most frequently associated with the onset of diabetes in children aged <5 years.Aims and objectives: We studied the prevalence of DKA at T1DM diagnosis and the frequency of partial remission (PR) in children from Wielkopolska province, Poland.Method: The cohort comprised 735 children aged 0–18 yea...

hrp0086p1-p238 | Diabetes P1 | ESPE2016

Correction of Carnitine Deficiency in Children with Recent Onset Type 1 Diabetes

Castell Anne Laure , Bibal Cecile , Gaignard Pauline , De Filippo Gianpaolo , Bougneres Pierre

Background: Carnitine deficiency (CD) has been reported in children at time of type 1 diabetes (T1D) diagnosis. By impairing free fatty acid ß-oxidation in liver, muscle mass and pancreatic ß cells, CD might impair glucose homeostasis and residual insulin secretion. We postulate that reversed of these FAO defects may help regenerate a healthier ß cell mass and increased the diabetes honeymoon duration.Objective: Evaluate the effects of car...

hrp0086p1-p239 | Diabetes P1 | ESPE2016

Fetal Growth Restriction Due to Maternal Congenital Hyperinsulinism Associated with a Novel Variant in GLUD1 and Intrauterine Diazoxide Exposure

Dirlewanger Mirjam , Klee Philippe , Ranza Emmanuelle , Gastaldi Giacomo , Boulvain Michel , Schwitzgebel Valerie M

Background: Congenital hyperinsulinism (CHI) is a rare disease mostly due to loss-of-function mutations of the ABCC8 or KCNJ11 genes, encoding the two subunits of the KATP channel. Gain-of-function mutations in glutamate dehydrogenase 1, encoded by the GLUD1 gene, are the second most common cause of CHI.Objective and hypotheses: The majority of patients with a GLUD1 CHI respond to diazoxide, but little is kn...

hrp0086p1-p240 | Diabetes P1 | ESPE2016

Effect of Vitamin D Supplementation on Lipid Profile in Vitamin D Deficient T1D Patients with Dyslipidemia

Hafez Mona , Musa Noha , Sharaf Sahar , Wahab Nehal Abdel

Background: It was suggested that vitamin D has both direct and indirect effects on modifying the lipid profile in patients with diabetes through its regulatory action that increases the activity of lipoprotein lipase in adiposity.Objective and hypotheses: To detect the relationship between serum 25(OH) D and lipid profiles in patients with T1D and dyslipidemia and to study the effect of vitamin D supplementation on lipid profiles of vitamin D deficient ...

hrp0086p1-p241 | Diabetes P1 | ESPE2016

Renal Functional Reserve in Children with Type 1 Diabetes

Zdravkovic Vera , Sajic Silvija , Stefanovic Darija , Jesic Maja , Cvetkovic Mirjana , Kostic Mirjana , Paripovic Dusan , Bojic Vladislav , Antic Amira Peco

Background: Early detection of diabetic nephropathy is of great importance. Renal functional reserve (RFR) is the difference between glomerular filtration rate (GFR) in basal conditions and GFR after a protein meal.Objective: To examine renal functional reserve in children with type 1 diabetes mellitus (T1D) in order to detect diabetic nephropathy at early stage.Method: Case control study included patient...

hrp0086p1-p242 | Diabetes P1 | ESPE2016

The Prognostic Role of Non-alcoholic Fatty Liver Disease in Children with Type 1 Diabetes Mellitus with and without Dyslipidemias

Navasardyan Lusine

Background: Recently it is shown that the clinical manifestation of non-alcoholic fatty liver disease (NAFLD) is not related only to liver, but also to cardiovascular complications and mortality. Nowadays there is growing evidence that dyslipidemia and NAFLD association is multisystemic disease, affecting other systems and regulatory pathways. Furthermore, diabetes mellitus worsens the risk of later chronic cardiovascular and atherogenic complications.Ob...

hrp0086p1-p243 | Diabetes P1 | ESPE2016

Associated and Familial Autoimmunity in Children and Adolescents with Type 1 Diabetes Mellitus

Papadopoulou Martha , Kallinikou Dimitra , Louraki Maria , Foteinou Aspasia , Karavanaki Kyriaki

Background: Type 1 Diabetes Mellitus (T1DM) often coexists with other autoimmune diseases, either individually or as a part of polyendocrine syndrome (APS I-III). It is frequently associated with autoimmune thyroid, celiac, gastric and Addison’s disease. In the families with T1DM patients frequently coexist different autoimmune diseases (familial autoimmunity).Objective and hypotheses: Evaluating the frequency of associated and familial autoimmunity...

hrp0086p1-p244 | Diabetes P1 | ESPE2016

Factors Affecting Dyslipidaemia in Children and Young People with Type 1 Diabetes Mellitus: A Multicentre Study

Upadrasta Swathi , Joseph Jude , Ayoola Omolola , Chandrasekaran Surendran , Ng Sze May

Background: Diabetic dyslipidaemia is characterized by high triglycerides (TG), low HDL cholesterol (HDL-C) and the presence of small, dense LDL. The UK National Paediatric Diabetes Audit (NPDA) 2013/14 reported that 16.1% of children and young people (CYP) with type 1 diabetes mellitus (T1DM) have a total cholesterol (TC) of ≥ 5 mmol/l. TG, LDL and TC-HDL-C were not reported in the NPDA. The significantly high prevalence of hypercholesterolemia in CYP with T1DM is conce...

hrp0086p1-p245 | Diabetes P1 | ESPE2016

Abstract withdrawn....

hrp0086p1-p246 | Diabetes P1 | ESPE2016

Wolcott Rallison Syndrome due to a Novel Mutation in EIF2AK3 Gene

Bhaskar Vikram , Thunga Chennakeshava , Tiwari Soumya

Background: Wolcott Rallison syndrome is a rare autosomal recessive disorder, characterized by early onset diabetes, skeletal dysplasia and growth retardation. Fewer than 100 cases have been reported in literature. We report a case of Wolcott Rallison syndrome caused by a novel mutation.Objective and hypotheses: To report a novel mutation of EIF2AK3 gene, which has never been reported previously.Method: Blood sample of a suspected ...

hrp0086p1-p247 | Diabetes P1 | ESPE2016

Which is the Best Site for Catheter Placement in Young Children with Type 1 Diabetes (T1D) and CSII?

Xatzipsalti Maria , Vakaki Marina , Patouni Konstantina , Kourti Afroditi , Mentesidou Lida , Choundala Anna , Stamoyannou Lela , Vazeou Andriani

Background: Few data exist for young children regarding the proper site for insulin catheter insertion for pump (CSII) users.Objective and hypotheses: To evaluate the proper site for catheter insertion in very young children (<8 year old) with T1D and CSII.Method: The study comprised 10 children [7 females, median age 4.43 years (range 2.3–7.18), median disease duration 1.65 years] with T1D who were on CSII. Ultrasound mea...

hrp0086p1-p248 | Diabetes P1 | ESPE2016

GCK Mutations in Chinese MODY2 Patients: A Family Pedigree Report and Review of Chinese Literature

Ping Xiao Yu , Xu Xiao Hua , Lan Fang Yan , Qiong Jiang Li , Chen Chun , Liang Li , Lin Wang Chun

Background: Maturity-onset diabetes of the young, type 2 (MODY2), caused by mutations in the glucokinase (GCK) gene is rare in a Chinese population.Objective and hypotheses: We report three Chinese families with MODY2 and sequenced the GCK gene to find novo mutation.Method: Three unrelated Chinese families with MODY2 and pedigrees were investigated. In Family 1, the proband was a 7-year-old girl with impaired fasting glucose (IFG) ...

hrp0086p1-p249 | Diabetes P1 | ESPE2016

Autoimmune Limbic Encephalitis Associated with Type 1 Diabetes Mellitus

Kilinc Ugurlu Aylin , Doger Esra , Demet Akbas Emine , Akin Onur , Arhan Ebru , Bideci Aysun , Camurdan Orhun , Cinaz Peyami

Background: Limbic encephalitis (LE) is a neurological disorder characterized with amnesia, seizures, personality changes. LE is usually considered as paraneoplastic disorder. Infections, paraneoplastic disorders and autoimmunity should be considered in LE etiology. Association of type 1 diabetes mellitus and LE is very rare. Here in we report a patient who was diagnosed with type 1 diabetes mellitus (T1DM) six months after LE occurrence.Case: A 17-year-...

hrp0086p1-p250 | Diabetes P1 | ESPE2016

Type 1 Diabetes (T1D) Management with Few Blood Glucose (BG) Measurements but Frequent Free Adjustment of Treatment with Cell Phones or E-mails

Bibal Cecile , Laure Castell Anne , Aboumrad Brigitte , Lucchini Philippe , Bougneres Pierre

Background: Many children with type 1 diabetes (T1D) are asked to measure blood glucose (BG) 4–6 times a day routinely to adjust insulin dosages. There is no evidence though that such high frequency is beneficial to HbA1C or glycemic profile, although this is often claimed.Objectives: We challenged ‘the more BG measurements, the better control’ dogma for alleviation of T1D burden in child life and evaluation of HbA1C.<p class="abstext"...

hrp0086p1-p251 | Diabetes P1 | ESPE2016

Metabolic Impairments among Adult Survivors of Paediatric Abdominal and Pelvic Tumours in the St Jude Lifetime Cohort Study

Wilson Carmen , Chemaitilly Wassim , Liu Wei , Srivastava Deokumar , Hudson Melissa , Robison Leslie , Ness Kirsten

Background: Adverse changes in metabolic parameters and body composition are frequently reported among childhood cancer survivors treated with cranial or total body irradiation. Data regarding the occurrence of metabolic impairments among survivors following abdominal and pelvic radiation are lacking.Objective and hypotheses: To define the prevalence of metabolic impairments among survivors of paediatric abdominal and pelvic solid tumours and to assess t...

hrp0086p1-p252 | Diabetes P1 | ESPE2016

Clinical Case of a 10-year-old Girl with Papillomatosis Due to Severe Insulin Resistance Type A

Orlova Elizaveta , Makazan Nadezhda , Kareva Maria , Mayorov Alexandr , Koksharova Ekaterina , Peterkova Valentina

Background: Severe insulin resistant (IR) type A is a rare inherited disorder characterized by glucose metabolism disturbances without obesity, acanthosis nigricans and hyperandrogenia due to INSR defects.Case report: A 10-year-old girl was admitted because of skin papillomatosis and hyperpigmentations since her 7 years. She had early puberty with pubarche at 8 years and telarche at 9 years. Examination revealed normal height and weight (SDS BMI...

hrp0086p1-p253 | Diabetes P1 | ESPE2016

Sulphonylurea Treatment in a Patient with Intermediate DEND Syndrome

Catli Gonul , Kocyigit Cemil , Gencpinar Pinar , Can Penbe S. , Dundar Nihal O. , Dundar Bumin N.

Background: DEND syndrome is characterized by developmental delay, epilepsy, and neonatal diabetes mellitus (NDM) due to mutations in KCNJ11 and ABCC8 genes. Intermediate DEND (iDEND) syndrome is a rare mild form with mild motor, speech or cognitive delay and an absence of epilepsy. Improvement in glycemic control and neurologic symptoms has been reported in three cases with iDEND syndrome.Objective and hypotheses: To present the result...

hrp0086p1-p254 | Diabetes P1 | ESPE2016

A Case-Control Search of Environmental (E) Factors for Childhood Type 1 Diabetes (T1D) Using Lifeline Questionnaires in the ISIS-Diab Cohort

Balazard Felix , Le Fur Sophie , Biau Gerard , Valleron Alain-Jacques , Bougneres Pierre

Background: The rapidly increasing T1D incidence in European children suggests the recent emergence or extension of predisposing E factors, or the decrease of protective E factors acting during pregnancy, infancy or early childhood. E research has preferentially focused on specific candidate factors, such as hygiene hypothesis, enteroviruses, alimentation, in cohort or case-control studies. The risk of bias is a major concern in E studies.Objectives: To ...

hrp0086p1-p255 | Diabetes P1 | ESPE2016

Transient Neonatal Diabetes Mellitus in Hanoi, Vietnam: Clinical Feature and Outcome

Can Thi Bich Ngoc , Vu Chi Dung , Bui Phuong Thao , Nguyen Ngoc Khanh , Docherty Louise , Edwards Sian , Mackay Deborah , Temple Karen , Ellard Sian

Background: Transient neonatal diabetes mellitus (TNDM) is a rare form of diabetes mellitus that presents within the first 6 months of life with remission in infancy or early childhood. TNDM is mainly caused by anomalies in the imprinted region on chromosome 6q24; however, recently, mutations in the ABCC8 gene, which encodes sulfonylurea receptor 1, have also been implicated in TNDM.Objective and hypotheses: To describe clinical features and lab...

hrp0086p1-p256 | Diabetes P1 | ESPE2016

The Incidence of Type 1 Diabetes in the Pediatric Population in Pomeranian Region in Poland

Brandt Agnieszka , Derkowska Ilona , Mysliwiec Malgorzata

Background: It is observed from nearly 50 years that the incidence of diabetes worldwide is increasing. Also the incidence of type 1 diabetes, which is most common in paediatric population, rises across Europe.Objective and hypotheses: The aim of the study was to analyze the incidence of type 1 diabetes in Poland in Pomeranian province in the years 2005, 2010 and 2015. The hypothesis was an increased incidence of type 1 diabetes.Me...

hrp0086p1-p257 | Diabetes P1 | ESPE2016

Health-Related Quality of Life and its Associated Factors in Children With Type 1 Diabetes Mellitus

Murillo-Valles Marta , Rajmil Luis , Bel-Comos Joan , Perez Jacobo , Corripio Raquel , Carreras Gemma , Herrero Xavier , Mengibar Jose-Maria , Rodriguez-Arjona Dolors , Ravens-Sieberer Ulrike , Raat Hein

Objective: To assess health-related quality of life (HRQOL) in a cohort of children and adolescents with type 1 Diabetes (T1DM) and its associated factors.Methods: This was a descriptive study of 136 patients with T1DM from five hospitals in Catalonia, Spain (72 girls, mean age 13.4 years (range 8–19). Inclusion criteria were more than 6 months from diagnosis, more than 8 years old and without cognitive problems. Sociodemographic (age, sex, family l...

hrp0086p1-p258 | Diabetes P1 | ESPE2016

Possible Monogenic Diabetes Mellitus Including Mody is Highly Prevalent in Korean Children with Diabetes Mellitus

Moon Jung-Eun , Cho Eun-Mi , Jang Kyung-Mi , Ko Cheol-Woo

Background: As the human genome is further explored, multiple genetic anomalies at different loci are being found that confer varying degrees of predisposition to diabetes. MODY is the most common form of monogenic diabetes, accounting 2–5 percent of diabetes. Recently, we have found and reported three noble gene variants relating to MODY in Korean children (Shim et al, Horm Res Pediatr, 2015).Objective and hypotheses: This study was done to see the...

hrp0086p1-p259 | Diabetes P1 | ESPE2016

Phenotype and Clinical Course of Diabetes Mellitus in Individuals with Pancreatic Hypoplasia Due to a PTFA Enhancer Mutation

Panou Evangelia , Gohlke Bettina , Woelfle Joachim

Background: Recently PTF1A enhancer mutations have been described in subjects with early-onset exocrine and endocrine pancreas insufficiency.Objective: To describe the clinical course in three children with PTF1A enhancer mutations, in particular anthropometric development, insulin requirement and diabetes control.Method: Retrospective analysis of growth, weight and BMI development as well as insulin requirement and HbA1c level in ...

hrp0086p1-p260 | Diabetes P1 | ESPE2016

Microalbuminuria in Type 1 Diabetes – Audit of Management of Children and Adolescents in a Single Diabetes Centre

Nambisan Aparna Kesavath Raman , Spowart Karen , Alatzoglou Kyriaki Sandy , Bridges Nicola , Alexander Saji

Background: There are international guidelines on screening for Microalbuminuria (MA) in children with Type1 Diabetes Mellitus (T1DM). But the National Paediatric Diabetic Audit, UK suggests that screening is missed in over 50% of cases. Further, there is little data on the management and natural course of MA in children by frontline units.Objective and hypotheses: To describe the prevalence, management and natural course of MA in children and adolescent...

hrp0086p1-p261 | Diabetes P1 | ESPE2016

Johansson-Blizzard Syndrome with Pan-hypopituitrism, Type 2 Diabetes and Pancreatic insufficiency: Effect of Treatment

Alyafie Fawzia , Soliman Ashraf

Background: Johanson-Blizzard syndrome (JBS) is a disease characterized by poor growth, variable dysmorphic features, including aplasia or hypoplasia of the nasal alae, sensori-neural deafness, abnormal hair patterns or scalp defects, and oligodontia. Other features of JBS include pan-hypopituitarism, imperforate anus, and PI. Pancreatic endocrine insufficiency (PI).Case study: AM is a 10 years-old boy, born at term with aplasia of the alae nasi and cong...