ESPE2016 Poster Presentations Syndromes: Mechanisms and Management P1 (36 abstracts)
Serum Levels of IL-6, TNF-a, Omentin-1 are Increased in Girls with Turner Syndrome
Hongshan Chen , Hui Xiong , Minlian Du , Yanhong Li , Huamei Ma , Quili Chen , Jun Zhang & Song Guo
Peadiatric Department, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
Objective: To assess the serum levels of IL-6, TNF-a and Omentin-1 in girls with Turner Syndrome (TS) and to analyze their association with FPG, FINS, TC, TG, HDL-c, LDL-c, and BMISDS.
Methods: In total of 33 TS girls aged (12.8±3.9) yr and 33 age-matched normal girls aged (12.6±3.7) yr were recruited in the study. Height (Ht) and Weight (Wt) were measured; FPG, FINS, TC, TG, HDL-c, LDL-c, IGF-1 and E2 were also measured; BMI and BMISDS were calculated. Serum IL-6, TNF-a were tested by CBA method and serum omentin-1 were tested by ELISA method.
Results: In TS group, BMI and BMISDS are greater than that in control group (all P<0.05), and the levels of TC, LDL-c, IL-6, TNF-a, omentin-1 are higher than that in control group (all P<0.05). IGF-1 and E2 levels are lower than those in control group (all P<0.01) (details in table 1). There is no statistically different of FINS, FPG and HOMA-IR between the two groups. IL-6 is positively correlated with BMISDS and TNF-a (rs=0.292, P<0.05; rs=0.565, P<0.001); TNF-a is positively correlated with BMISDS (rs=0.420, P=0.001); omentin-1 was positively correlated with BMISDS (rs=0.322, P<0.05).
| Parameters | TS group | Control group | P value |
| Age (yr) | 12.8±3.8 | 12.7±3.7 | >0.05 |
| Body height (cm) | 126.4±13.2 | 143.2±17.5 | 0.000 |
| Body weight (Kg) | 28.0±7.7 | 34.8±11.0 | 0.000 |
| BMI (kg/m2) | 17.2±2.2 | 16.1±1.9 | 0.008 |
| BMISDS | −0.5±1.0 | −1.0±0.8 | 0.023 |
| IGF-1 (ng/ml) | 191.5±90.6 | 331.1±172.5 | 0.001 |
| FINS (μu/ml) | 6.5±1.4 | 6.6±1.4 | >0.05 |
| FPG (mmol/L) | 4.7±0.4 | 4.6±0.3 | >0.05 |
| HOMA-IR | 1.4±0.4 | 1.4±0.3 | >0.05 |
| TC (mmol/L) | 4.5±0.7 | 4.1±0.4 | 0.007 |
| TG (mmol/L) | 1.0±0.5 | 0.9±0.3 | >0.05 |
| HDL-c (mmol/L) | 1.4±0.3 | 1.4±0.2 | >0.05 |
| LDL-c (mmol/L) | 2.8±0.6 | 2.5±0.2 | 0.014 |
| E2 (pg/ml) | 10.4±1.1 | 34.4±18.5 | 0.002 |
| IL-6 (pg/ml) | 2.7±2.1 | 1.2±0.9 | 0.000 |
| TNF-a (pg/ml) | 0.9±0.8 | 0.4±0.5 | 0.004 |
| Omentin-1 (ng/ml) | 1.6±1.2 | 0.9±1.7 | 0.008 |
Conclusions: Serum levels of IL-6, TNF-a, Omentin-1, TC, and LDL-c are increased in girls with TS. Further investigation is needed to illustrate the relationship among these factors and the metabolic disorders in TS patients.
Keywords: IL-6; TNF-a; Omenitn-1; Turner syndrome; Children and adolescents
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