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55th Annual ESPE

Paris, France
10 Sep 2016 - 12 Sep 2016

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Paris, France: 10-12 September 2016 Further information

hrp0086p2-p932 | Thyroid P2 | ESPE2016

Multinodular Goiter and Differentiated Thyroid Cancer in Pediatrics

Papendieck Patricia , Venara Marcela , Elias Eugenia , Cozzani Hugo , Mateos Fernanda , Maglio Silvana , de Lujan Calcagno Maria , Gruneiro-Papendieck Laura , Bergada Ignacio , Chiesa Ana

Background: In a recent report we have identified multinodular goiter (MNG) as a condition with an increased risk for thyroid malignancy in children and adolescents.Objective and hypotheses: To report the prevalence and characterization of a prospectively and uniformly followed cohort of pediatric patients with MNG and to retrospectively analyze differences between benign and malignant MNG before surgery in order to identify malignancy predictors.<p ...

hrp0086p2-p933 | Thyroid P2 | ESPE2016

Clinical Case of Acute Liver Injury in Pediatric Patient with Autoimmune Hyperthyroidism

Caiulo Silvana , Vigone Maria Cristina , Peroni Elena , di Frenna Marianna , Saracco Luca , Memoli Massimo , Barera Graziano , Weber Giovanna

Background: Autoimmune hepatitis (AIH) and methimazole (MMI)-induced toxic hepatitis are both rare diseases in pediatric age.Case presentation: We present the case of a 15-year-old girl affected by idiopathic arthritis and autoimmune thyroiditis. The autoimmune thyroiditis was diagnosed at 13 years of age. At 15 years old she developed hyperthyroidism (TSH <0.01 mcU/ml, FT4 2.3 ng/dl, FT3 8.4 pg/ml, TRAb 18 IU/l) and was treated with MMI (0.28 mg/kg ...

hrp0086p2-p934 | Thyroid P2 | ESPE2016

Thyroid Function in Children Affected By Congenital Hypothyroidism (CH) with Eutopic Thyroid After Discontinuation of Treatment with Levothyroxine

Poggi Elena , Gastaldi Roberto , Muraca Monica , Perri Katia , Pistorio Angela , Maghnie Mohamad

Objective and hypotheses: We analysed the prevalence of transient hypothyroidism in a cohort of children affected by CH with eutopic thyroid after Levothyroxine discontinuation.Method: 77 newborns (36 females, 41 males) affected by CH with eutopic thyroid from 1999 to 2011 were enrolled. The confirmation diagnosis of CH after screening was made within the first 15 days of life by assessing TSH value (mean 74.4±82.2 μU/ml n.v 0.5–4.2) and f...

hrp0086p2-p935 | Thyroid P2 | ESPE2016

Hyperthyroidism in an Infant of a Mother with Autoimmune Hypothyroidism with Positive TSH Receptor Antibodies

Joshi Kriti , Zacharin Margaret

Background: Neonatal hyperthyroidism is a rare condition seen in infants born to mothers with Graves disease, with transplacental transfer of TSH receptor antibodies (TRAb) to the baby. Some patients have been shown to swing from hypothyroidism to hyperthyroidism as TSH receptor blocking and stimulating antibodies may coexist.Objective and hypotheses: To describe a rare clinical event of a neonate with severe Graves hyperthyroidism, born to a mother with...

hrp0086p2-p936 | Thyroid P2 | ESPE2016

Thyroid Cancer Presentation in Children is Different than in Young Adults

Cannavo Laura , Wasniewska Malgorzata , Zirilli Giuseppina , Violi Maria Antonia , Vermiglio Francesco , De Luca Filippo

Background: Differentiated thyroid cancer (DTC) in pediatric age might have peculiar course and prognosis.Objective and hypotheses: To compare clinical, biochemical and ultrasound (US) features at diagnosis, histological grading and outcome in two groups of children and young adults with DTC.Method: Clinical, biochemical and imaging characteristics of 63 patients with DTC, diagnosed between 1999 and 2014 in our hospital, were retro...

hrp0086p2-p937 | Thyroid P2 | ESPE2016

Starting Treatment in Congenital Hypothyroidism with Normal FT4 Levels and Thyroid Gland in situ Detected at Neonatal Screening

Paone Laura , Gubinelli Jessica , Scire Giuseppe , Ubertini Graziamaria , Cappa Marco

Background: Recently congenital hypothyroidism (CH) is increased,particularly mild forms. Current guidelines recommend initial levothyroxine (LT4) dose of 10–15 mcg/kg per day as soon as possible, if diagnosis is confirmed by serum test, even if FT4 concentration is normal and venous TSH concentration is >20 microUI/ml.Objective and hypotheses: The aim of our study was to evaluate the initial LT4 dose in newborn with congenital hypothyroidism, n...

hrp0086p2-p938 | Thyroid P2 | ESPE2016

Distal Monosomy 10q Presented as Congenital Hypothyroidism

Braha Elena Emanuela , Rusu Cristina , Armasu Ioana , Belceanu Alina , Popescu Roxana , Bursuc Anamaria , Vulpoi Carmen

Background: Distal monosomy 10q is a rare chromosomal anomaly characterized by unusually slow growth before and after birth, mild to severe intellectual disability and distinctive craniofacial features (hypertelorism, strabismus, a prominent or broad nasal bridge, and posteriorly rotated low-set ears). Some other anomalies have been described in various systems. The behavioral profile was characterized by marked inattention, hyperactivity and impulsivity. In recent years, subt...

hrp0086p2-p939 | Thyroid P2 | ESPE2016

Five-Year Prospective Evaluation of Thyroid Function Test Evolution in Children with Hashimoto’s Thyroiditis Presenting with Either Euthyroidism or Subclinical Hypothyroidism

Aversa Tommaso , Corrias Andrea , Salerno Mariacarolina , Tessaris Daniele , Di Mase Raffaella , Valenzise Mariella , Corica Domenico , De Luca Filippo , Wasniewska Malgorzata

Background: It had never been investigated to now whether the course of thyroid function in Hashimoto’s thyroiditis (HT) may differ in the children who had presented with either euthyroidism or subclinical hypothyroidism (SH).Objective and hypotheses: To establish, by means of a 5-year prospective evaluation of 234 children with HT and no prognostic risk factors, whether thyroid status evolution over time may be conditioned by the biochemical patter...

hrp0086p2-p940 | Thyroid P2 | ESPE2016

An Unusual Case of Impaired Renal Function and Thrombocytopenia

Cima Luminita Nicoleta , Lungu Adrian , Ionescu Bogdan , Lambrescu Ioana Maria , Barbu Carmen Gabriela , Fica Simona

Background: Autoimmune thyroid disease can be sometimes associated with autoimmune thrombocytopenia and decreased renal function.Case report: A 17-year-old female patient was referred to our endocrine department for evaluation of hypothyroidism (TSH=150 mcIU/ml, FT3=0 pg/ml, FT4<0.1 ng/dl) presenting severe fatigability and myalgia. From her medical history we mention that she was diagnosed with thrombocytopenia 1 year ago (85.000/mm...

hrp0086p2-p941 | Thyroid P2 | ESPE2016

Celiac Disease in Children and Adolescents with Hashimoto Thyroiditis

Tuhan Hale , Isik Sakine , Abaci Ayhan , Simsek Erdem , Anik Ahmet , Anal Ozden , Bober Ece

Background: Hashimoto thyroiditis (HT) is part of the spectrum of autoimmune thyroid diseases and is characterized by the destruction of thyroid cells by various cell- and antibody-mediated immune processes.Objective and hypotheses: The aim of this study was to evaluate clinical and laboratory findings and determine the prevalence of celiac disease (CD) in children with HT.Method: A total of 80 patients with positive anti-thyroid a...

hrp0086p2-p942 | Thyroid P2 | ESPE2016

Euthyroid Hashimoto Thyroiditis in Children: Evolution Over Time

Karachaliou Feneli , Kafetzi Maria , Vlachopapadopoulou Elpis , Thomas Dimitris , Kaloumenou Irene , Fotinou Aspasia , Karavanaki Kyriaki , Michalakos Stefanos

Background: The natural evolution of euthyroid Hashimoto thyroiditis (HT) varies among children and treatment in children with HT and normal/mild elevated serum TSH is controversial.Objective and hypotheses: The aim was to study the natural course of HT in children and evaluate predictive factors of thyroid functionMethod: We evaluated data from 87 children retrospectively (63 girls, 24 boys), mean age 10.6±3.2yrs, with HT [an...

hrp0086p2-p943 | Thyroid P2 | ESPE2016

Thyrotoxic Periodic Paralysis, an Under-Recognized Condition

Nip Siu Ying , Di Blasi Carolina

Background: Thyrotoxic periodic paralysis (TPP) is a rare clinical manifestation of hyperthyroidism, commonly seen in Asian males. Patients often present with sudden onset muscle weakness associated with severe hypokalemia.Case presentation: A 16-year-old Filipino male presented with acute onset bilateral lower extremities weakness. He woke up at night but was unable to move his legs. He denied any recent viral infections, ingestion of canned food or his...

hrp0086p2-p944 | Thyroid P2 | ESPE2016

Age at Diagnosis and Mental Development in Children with Congenital Hypothyroidism in the Absence of Newborn Screening Programme

Ouarezki Yasmine , Ladjouze Asmahane , Kherra Sakina , Djermane Adel , Laraba Abdennour

Background: The outcome of congenital hypothyroidism (CH) has dramatically changed since the start of neonatal screening. However the benefit of this program is not felt in Algeria and other countries where the pathology is still causing irreparable brain damage.Objective and hypotheses: To evaluate age at diagnosis of CH and its impact on the mental development in the absence of new-born screening.Method: Case notes of all patient...

hrp0086p2-p945 | Thyroid P2 | ESPE2016

Vitamin D Levels in Children with Hashimoto’s Thyroiditis: Before and after I-Thyroxine Therapy

Chaudhary Navendu , Kumar Rakesh , Sachdeva Naresh , Dayal Devi

Background: There is high prevalence of Vitamin D deficiency (VDD) in Hashimoto’s thyroiditis (HT) as reported in literature. However, it is uncertain whether VDD is a cause or effect of HT. The effect L-thyroxine replacement on vitamin D levels in children with HT has not been studied.Objective and hypotheses: To study vitamin D level of newly diagnosed children with HT and to observe the change in vitamin D level after L-thyroxine therapy.<p c...

hrp0086p2-p946 | Thyroid P2 | ESPE2016

The Aim of This Study was to Recognize Difference between Transient Congenital Hypothyroidism (TCH) from Permanent Congenital Hypothyroidism by Determining Clinical Characteristics, Laboratory Tests and Imaging Studies

Kim Se Young , Kim Min Sub

Methods: We performed retrospective study using database of the patients with congenital hypothyroidism treated with or without Levo-Thyroxine at Bundang Jesaeng General Hospital, from January 1998 to February 2016. Their ages, birth weights, gestational ages, symptoms, ages at diagnosis and treatment were recorded. We measured TSH, free thyroxine (FT4), triiodothyronine (TT3) levels at diagnosis and treatment, and those levels at one, two and three months after treatment. Thy...

hrp0086p2-p947 | Thyroid P2 | ESPE2016

Delayed Diagnosis of a TSH-Adenoma due to Coexisting Autoimmune Thyroid Disease

Crudo David , Constantacos Catherine , Walsh Elizabeth

Background: TSH-secreting pituitary adenomas are rare, accounting for less than 2% of all pituitary adenomas. Their diagnosis may be difficult when a coexistence of other diseases masks the typical clinical and biochemical manifestations of TSH-hypersecretion.Objective: To report a case of a TSH-adenoma without signs/symptoms of hyperthyroidism due to underlying autoimmune thyroid disease.Results: Patient is a 17 year old male who ...

hrp0086p2-p948 | Thyroid P2 | ESPE2016

Kocher-Debre-Semelaigne Syndrome: Hypothyroidism with Muscle Pseudohypertrophy

Bogova Elena , Deryagina Alesya , Shyryaeva Tatyana , Tulpakov Anatoly

Background: Kocher-Debre Semelaigne syndrome (KDSS) is a rare form of myopathy in patients with longstanding moderate-to-severe hypothyroidism.Objective and hypotheses: We present the case of 7-year-old boy who developed muscular pseudohypertrophy, associated with long-term untreated hypothyroidism.Method: A 7-year-old boy presented with growth failure, lassitude and lethargy. He was born small for gestational age at 28 weeks gesta...

hrp0086p2-p949 | Thyroid P2 | ESPE2016

Thyroid Function in Obese Children and Its Correlations with Chosen Atherogenic Risk Factors

Ruminska Malgorzata , Witkowska-Sedek Ewelina , Majcher Anna , Pyrzak Beata

Background: Moderately elevated thyroid-stimulating hormone (TSH) with normal serum concentrations of free thyroxine (fT4), suggesting subclinical hypothyroidism, is the most common hormonal abnormality in obese children. Controversy remains whether thyroid dysfunction related to obesity has an influence on the cardiovascular risk factors.Objective and hypotheses: The aim of the study was to assess correlation between TSH and fT4 and chosen atherogenic r...

hrp0086p2-p950 | Thyroid P2 | ESPE2016

The Evolution of Thyroid Function after Hashimoto’s Thyroiditis Presentation is Different in Initially Euthyroid Girls with or without Turner Syndrome

Wasniewska Malgorzata , Salerno Mariacarolina , Corrias Andrea , Mazzanti Laura , Matarazzo Patrizia , Corica Domenico , Aversa Tommaso , Messina Maria Francesca , De Luca Filippo , Valenzise Mariella

Background: Hashimoto’s thyroiditis (HT) is the commonest autoimmune disorder in Turner syndrome (TS). Although there are in the pediatric literature many studies on the relationships between TS and HT, only few of them have specifically investigated whether the association with TS might be able to significantly affect the evolution over time of thyroid function in children and adolescents with HT, by conditioning a different thyroid status prognosis.<p class="abstext...

hrp0086p2-p951 | Thyroid P2 | ESPE2016

Hashimoto’s Thyroiditis in Childhood: An 8 Year Experience

Oikonomakou Maria-Zoi , Oikonomou Maria-Irini , Giannopoulou Sotiria , Filias Athanasios , Krokidas Georgos , Iliopoulou Maria

Background: Hashimoto’s thyroiditis (HT) is the most common thyroid disorder in the pediatric population.Objective and Hypotheses: The aim of the present study was to observe clinical manifestations, clinical course and long term outcomes of HT in children and adolescents.Method: A total of 110 children and adolescents who presented to our center from 2008–2015, were evaluated retrospectively. Age and gender of the patien...

hrp0086p2-p952 | Thyroid P2 | ESPE2016

Congenital Malformations, Dysmorphic Syndromes and Neurodevelopmental Problems in Children with Congenital Hypothyroidism

Gkini Marianthi , Gika Anna , Iliadi Alexandra , Platis Dimitris , Giogli Vasiliki , Tataropoulou Kasandra , Paltoglou Giorgos , Kogia Christina , Karagiannis Apostolos , Chrousos George , Girginoudis Panagiotis , Kanaka-Gantenbein Christina , Voutetakis Antonis

Background: A high frequency of extrathyroidal congenital anomalies has been reported in infants with congenital hypothyroidism (CH) detected by neonatal screening. Current ESPE guidelines suggest that congenital malformations, underlying dysmorphic syndromes and psychomotor and language development should be sought for and monitored in CH patients. The identification of co-existing nosologies and malformations is helpful not only for clinical purposes but also for uncovering ...

hrp0086p2-p953 | Thyroid P2 | ESPE2016

Clinical Value of Thyroid-Stimulating Immunoglobulin in Paediatric Autoimmune Thyroid Diseases

Stozek Karolina , Bossowski Artur , Ziora Katarzyna , Bossowska Anna , Diana Tanja , Kahaly George J

Background: In Autoimmune Thyroid Disease (AITD) two types of TSH receptor antibodies (TSHR-Ab) may be distinguished: thyroid- stimulating immunoglobulin (TSI) that promotes the production of thyroid hormones and thyroid- blocking immunoglobulin (TBI) inhibiting the activity of TSH what leads contrarily to hypothyroidism.Objective and hypotheses: The aim of this study was to compare mean TSI and TBI levels in large paediatric cohort with AITD and control...

hrp0086p2-p954 | Thyroid P2 | ESPE2016

Hearing, Language and Communication Abilities in Children with Congenital Hypothyroidism

Cooper Hannah , Peters Catherine , Halliday Lorna , Bamiou Doris-Eva , Clark Christopher

Background: Thyroid hormones are essential in the regulation of foetal and post-natal neurodevelopment. Despite early diagnosis and treatment of congenital hypothyroidism (CH) difficulties with language, hearing, memory and motor function persist for some children. However, comprehensive data about hearing, language and communication function in children with CH are not widely available.Objective and hypotheses: To evaluate hearing, language and communic...

hrp0086p2-p955 | Thyroid P2 | ESPE2016

Lack of Catch Up Growth in Severe Hashimoto Thyroiditis (HT) in Young Children

Vincent Audrey , Rodrigue Danielle , Teinturier Cecile , Bouvattier Claire , Bougneres Pierre , Linglart Agnes

Background: Profound hypothyroidism due to Hashimoto thyroiditis (HT) is a cause of severe growth arrest in children. Although it is commonly thought that thyroxine replacement fully restores height deficit, no data on catch up growth are available.Objective and hypotheses: Assess the growth pattern and final height in a series of 10 patients with severe HT afec L-thyroxine therapy was initiated.Method: Monocentric retrospective ob...

hrp0086p2-p956 | Thyroid P2 | ESPE2016

Perinatal Factors Associated with Neonatal Thyroid Stimulating Hormone in Normal Newborns

Lee Seong Yong

Background: Neonatal thyroid stimulating hormone (TSH) is influenced by several factors. But the effects are not consistent but different depending on subjects and kind of blood sample.Objective and hypotheses: This study was to evaluate the effect of neonatal, maternal, and delivery factors on neonatal TSH of healthy newborns.Method: Medical records of 713 healthy infants born through normal vaginal delivery were reviewed. TSH lev...

hrp0086p2-p957 | Thyroid P2 | ESPE2016

TBG Excess as a Cause of Hyperthyroxinemia and High T3 Detected Incidentally or Through Neonatal Screening Test

Jin Hye Young

Inherited thyroxine binding globulin (TBG) disorder can be identified incidentally or through neonatal screening test. TBG excess is characterized by high levels of thyroxine (T4) but normal level of free T4 (fT4), while TBG deficiency presents with low T4 levels and normal fT4 levels. TBG excess is caused by TBG gene duplication or triplication. A 27 day old newborn was brought to the hospital because of hyperthyroxinemia that was identified through neonatal screenin...

hrp0086p2-p958 | Thyroid P2 | ESPE2016

Beta Thallassemia: The Relation between Ferritin and Hypothyroisdism and the Suppressing Effect of Ferritin on Autoimmune Disorders (a Hypothesis)

Dalili Setila , Koohmanaee Shahin

Background: Thallassemia is a genetic disease with recessive autosomal pattern of inheritance which occurs as a result of disorders in hemoglobin structure clinicians assess endocrine function in patients with thallassemia in various intervals and distinguishing appropriate time for assessment can decrease the mentioned complications and promote their health.Objective and hypotheses: We aimed to investigate the prevalence of hypothyroidism and the relati...

hrp0086p2-p959 | Thyroid P2 | ESPE2016

Thyroid Hormones and Risk Factors in Obese and Overweight Children

Giannopoulou Sotiria , Oikonomou Maria-Irini , Vaggopoulou Chari , Krokidas Georgos , Iliopoulou Maria

Background: Thyroid stimulating hormone (TSH) and free thyroxine (fT4) levels in children with obesity vary from normal to elevated. Thyroid hormones influence body weight, heart rate, serum lipids as well as carbonhydrates metabolism.Objective and hypotheses: The aim of current study is to determine the relation between thyroid function in obese and overweight children and clinical-laboratory parameters which have been associated with i...

hrp0086p2-p960 | Thyroid P2 | ESPE2016

FNA: A Gold Standard in the Diagnosis of Thyroid Nodules in Children after Chemotherapy

Leka-Emiri Sofia , Petychaki Fotini , Petrou Vassilis , Vakaki Marina , Pourtsidis Apostolos , Vlachopapadopoulou Elpida , Michalakos Stefanos

Background: Non Hodgkin lymphoma (NHL) is the fourth most common malignancy in childhood. Chemotherapy constitutes the first line treatment and may cause several endocrine side effects (growth retardation, hypergonadotrophic hypogonadism, bone mass loss and rarely secondary malignancy). In total of 1–2% of children may harbour thyroid nodules. The most common risk factors are: irradiation, female sex, iodine deficiency, puberty and past medical history of thyroid disease....

hrp0086p2-p961 | Thyroid P2 | ESPE2016

Profound Growth Failure in Peripubertal Adolescents Presenting with Severe Acquired Autoimmune Hypothyroidism: A Case Series

Upadrasta Swathi , Soni Astha , Ng Sze May

Background: Children with severe hypothyroidism are known to present with significant growth restriction. Institution of treatment with thyroxine (T4) results in catch-up growth. However, treatment commenced in pubertal period may result in loss of adult height in cases with longstanding severe hypothyroidism.Objective and hypotheses: The objective of our study is to evaluate the presentation, investigations and catch-up growth after initiatio...

hrp0086p2-p962 | Thyroid P2 | ESPE2016

Two Patients with Resistance to Thyroid Hormones

Papatya Cakir Esra Deniz , Gorukmez Orhan , Ucakturk Seyit Ahmet , Kibar Ayse Esin , Sangun Ozlem , Erdem Sevcan , Ozen Samim

Background: Resistance to thyroid hormone (RTH) is an inherited syndrome characterized by reduced sensitivity of target tissues to thyroid hormone.Objective and hypotheses: We describe the clinical, biochemical data and mutation analysis of two patients and their families with (RTH).Method: We conducted clinical studies and genetic analysis of these two patients and their families.Results: First patient refer...

hrp0086p2-p963 | Thyroid P2 | ESPE2016

The Influence of Etiology and Treatment Factors on Intellectual Outcome in Congenital Hypothyroidism

Yoon Jong Seo , Lee Hae Sang , Lim Jung Sub , Hwang Jin Soon

Background: Congenital hypothyroidism (CH) is the one of the most common preventable cause of mental retardation. Earlier and proper treatment is associated with better intellectual outcomes.Objective and hypotheses: The aim of the present study was to evaluate intellectual outcome of children with diagnosed congenital hypothyroidism (CH) and early onset treatment.Method: We retrospectively reviewed the medical record of 43 childre...

hrp0086p2-p964 | Thyroid P2 | ESPE2016

An Unusual Complication of Graves’ Disease

Adesokan Akintayo , Vigneswaran Trisha , Mathur Sujeev , Cheung Moira , Ajzensztejn Michal

Background: Atrioventricular (AV) conduction defects are rare but significant complications of hyperthyroidism. Beta-blockers and co-existent infection further increase the risk of such conduction abnormalities.Objective and hypotheses: We report the case of a 10-year old girl treated for tachycardia and hypertension associated with hyperthyroidism who developed symptomatic 2:1 heart block.Method: Our patient presented with a histo...

hrp0086p2-p965 | Thyroid P2 | ESPE2016

An Unusual form of Precocious Puberty: Van Wyk and Grumbach Syndrome

Anık Ahmet , Avcı Esma Cigdem , Unuvar Tolga

Introduction: The association of precocious puberty and/or polycystic ovaries, delayed bone age and hypothyroidism is known as the Van Wyk and Grumbach syndrome (VWGS). Clinically this syndrome is a diagnostic challenge because hypothyroidism usually leads to pubertal and growth delay, whereas in case of VWGS hypothyroidism it leads to growth delay and precocious puberty. We report a boy with long-standing, untreated hypothyroidism who presented with precocious puberty.<p ...

hrp0086p2-p966 | Thyroid P2 | ESPE2016

Clinical Features of Newborn with Congenital Hypothyroidism Diagnosed by Neonatal Screening: Single Center Experience

Guven Ayla , Hazer İlhan

Background: Congenital hypothyroidism (CH) is the most important cause of preventable mental retardation. Therefore, screening programme has been using for early detection of hypothyroidism in our country since 2007.Objective: To compare clinical features of newborns with and without CH who were detected in screening programme between 2009 and 2014.Method: This study enrolled 710 (344 Girls) newborn referred from CH-screening progr...

hrp0086p2-p967 | Thyroid P2 | ESPE2016

Postoperative Complications of Thyroidectomy in Children with Nodular Goiter

Rogova Olga , Okminyan Goar , Samsonova Lubov , Kiseleva Elena , Latyshev Oleg , Kasatkina Elvira , Mirakov Kirill , Okulov Alexey

Background: Objective and hypotheses: Rate the frequency and structure of post-operative complications of thyroidectomy in children with nodular goiter.Method: Twenty-seven children, 20 girls (14.5±3.64 years) and seven boys (14.68±4.09 years), which were performed thyroidectomy about multinodular goiter (n=23) and single-node goiter (n=4) from 2003 to 2015. Were evaluated complaints of patients, physica...

hrp0086p2-p968 | Thyroid P2 | ESPE2016

Peculiarities of Course and Therapy of Basedow–Graves’ Disease in Children in Different Age Groups

Meraai Galina , Bakhar Hanna , Kliuchnikava Tatsiana , Solntsava Anzhalika

Suitably treatment of Basedow–Graves’ disease (BGD) provide the minimization of time to develop the medicamental remission. Research: determine clinical, laboratory particularities, evaluate efficiency of pharmaceutical treatment of BGD in children in different age groups. Materials and methods: 35 children with BGD were examined (4 boys, 31 girls): 1st group (Tanner 1) n=4, 7.5±0.65 years; 2nd – (Tanner 2–4) n=22, 12.32±0.31 yea...

hrp0086p2-p969 | Thyroid P2 | ESPE2016

An Unusual Presentation of Hashimoto Thyroiditis (HT) and Precocious Puberty: The Van Wyk-Grumbach Syndrome

Leka-Emiri Sofia , Karachaliou Feneli , Fotinou Aspasia , Petrou Vassilis , Michalakos Stefanos

Background: The association of primary hypothyroidism and isosexual precocious pseudopuberty in females was first described in 1960 by Van Wyk and Grumbach. The unique elements that lead to the diagnosis are FSH-dominated sexual precocity with non advanced bone age in the presence of hypothyroidism.Objective and methods: Describe an 8.5 years old girl with hypothyroidism due to HT and clinical and hormonal features of Van-Wyk and Grumbach syndrome.<p...

hrp0086p2-p970 | Thyroid P2 | ESPE2016

Rare Case of Severe Hyperthyroidism due to Grave’s Disease in a Female Toddler

Salemi Parissa

Background: Hyperthyroidism due to Grave’s disease (GD) in children has a peak incidence between 10 and 15 years of age. It is a rare but serious disorder that if uncontrolled can have serious adverse outcomes on growth and development as well as health. The incidence of GD is believed to be between 0.1 and 3 per 100 000 children in the general population with a prevalence of 1/10 000 children in the US. GD is rare under the age of 5 years.Objective...

hrp0086p2-p971 | Thyroid P2 | ESPE2016

Youngest Known Case of Autoimmune Thyroiditis Causing Hyperthyroidism in a Down’s Syndrome Toddler

Salemi Parissa

Background: The frequency of thyroid disease is elevated in patients with Down’s syndrome starting in the newborn period where it is 0.7% (28× more frequent than in the general population). Most commonly, thyroid dysfunction in Downs Syndrome includes primary hypothyroidism, pituitary–hypothalamic hypothyroidism, TBG deficiency and chronic lymphocytic thyroiditis. The incidence of Grave’s disease is believed to be between 0.1 and 3 per 100 000 children in t...

hrp0086p2-p972 | Thyroid P2 | ESPE2016

Thyroid Hormones in Obese Children

Vallianatou Markella , Katsikareli Evanthia , Tsami Parthenia , Krokidas Georgos , Iliopoulou Maria

Background: Nowadays, childhood obesity is one of the biggest health emergencies in the developed countries. Obesity leads to multiple metabolic disorders. Thyroid function has been often described as altered in obese children. However, it is not clear whether the thyroid dysfunction is the cause or the consequence of the fat excess.Objective and hypotheses: The aim of the current study was to examine the thyroid function and to assess the frequency of t...

hrp0086p2-p973 | Thyroid P2 | ESPE2016

A Case of Neonatal Graves in a Premature Infant with Negative Thyroid Stimulating Immunoglobulins (TSI)

Samuel Angela , Davis Vanessa , Minutti Carla , Mantis Stelios

Background: Neonatal hyperthyroidism is almost always transient and related to the passage of maternal thyroid stimulating immunoglobulins (TSI). Positive TSI levels in a neonate is often diagnostic of neonatal Graves disease. The manifestation of symptoms has not been well characterized in premature infants.Clinical Case: A female infant was delivered at 27×4/7 weeks gestational age, with a birth weight of 827 g. Her mother was diagnosed with Grave...

hrp0086p2-p974 | Thyroid P2 | ESPE2016

Severe Growth Retardation and Hypothyroidism due to Hashimoto’s Thyroidits

Krstevska-Konstantinova Marina , Stamatova Ana , Gucev Zoran

Background: Hashimoto’s thyroiditis is a common autoimmune disease in pubertal and adolescent girls. In the past years the incidence of this autoimmune disease of the thyroid gland has increased.Objective and hypotheses: We present a 12.5 year old girl who had her first visit at our Pediatric Endocrinology Department at the age of 10 years due to short stature and clinical signs of hypothyroidism. Her height was – 3SD SDS and her BMI was 12.7. ...

hrp0086p2-p975 | Thyroid P2 | ESPE2016

Beta Thallassemia: the Relation between Ferritin and Hypothyroisdism and the Suppressing Effect of Ferritin on Autoimmune Disorders (a Hypothesis)

Dalili Setila , Koohmanaee Shahin

Background: Thallassemia is a genetic disease with recessive autosomal pattern of inheritance which occurs as a result of disorders in hemoglobin structure clinicians assess endocrine function in patients with thallassemia in various intervals and distinguishing appropriate time for assessment can decrease the mentioned complications and promote their health, we aimed to investigate the prevalence of hypothyroidism and the relation between thyroid hormones and ferritin in pati...

hrp0086p2-p976 | Thyroid P2 | ESPE2016

Severe Hyponatremia and Repeated Intestinal Resections for Intestinal Dysmotility Mimicking Congenital Aganglionic Megacolon due to Delay in the Diagnosis of Congenital Hypothyroidism

Buyukyilmaz Gonul , Baltu Demet , Soyer Tutku , Tanyildiz Murat , Demirbilek Huseyin

Background: Congenital hypothyroidism (CH), the most common preventable cause of mental retardation in children, may presents with non-specific signs and symptoms. Beside, majority of the infants can be asymptomatic. Underestimation and/or misdiagnosis may cause delay in diagnosis and results in severe complications.Case report: A 5 months-old female admitted to our clinic with the history of repeated surgical operations due to the diagnosis of congenita...

hrp0086p2-p977 | Thyroid P2 | ESPE2016

Very Early Onset of Autoimmune Thyroiditis in a Toddler with Multi-organ Involvement

Marzuillo Pierluigi , Grandone Anna , Di Sessa Anna , Sanso Claudia , De Nitto Elena , Ruggiero Laura , Capristo Carlo , del Giudice Emanuele Miraglia , Perrone Laura

Background: In infants under 3 years of age acquired primary hypothyroidism caused by autoimmune thyroiditis is very rare. Hypothyroidism can manifest with different signs and symptoms and has a wide range of presentations from subclinical hypothyroidism to overt form.Objective and hypotheses: We describe a child with an unusual hypothyroidism presentation characterized by multi-organ involvement and related to acquired autoimmune thyroiditis during a ve...

hrp0086p2-p978 | Thyroid P2 | ESPE2016

A Case of the Thyroid Gland Dystopia in the Root of the Tongue

Chumak Svitlana , Volosova Vera , Sapozhnikova Irina

Background: Dystopia thyroid is an anomaly of development and is the result of a violation of embryogenesis and often remains unrecognized, the true frequency of the dystopia of the thyroid gland is not known, described 800 cases of ectopic thyroid gland in the region of blind holes of the tongue in adults and 80 cases in children, half of them diagnosed congenital hypothyroidism.Objective and hypotheses: To reveal some features in the diagnosis and trea...

hrp0086p2-p979 | Thyroid P2 | ESPE2016

Conversion of Hypothyroidism to Hyperthyroidism in A Child with Down’s Syndrome

Alshahrany Abdullah

Background: Patients with Down’s syndrome have an increased prevalence of autoimmune disorders affecting both endocrine and non endocrine organs. The commonest autoimmune disease is related to the thyroid gland.Objective and hypotheses: To describe a child with down’s syndrome who has been treated of hypothyroidism But converted to hyperthyroidism few years later.Method: A 5-year old boy with Down’s syndrome presente...

hrp0086p2-p980 | Thyroid P2 | ESPE2016

Transient Congenital Hypothyroidism: About Six Cases

Haddam Ali El Mahdi , Fedala Nora Soumeya , Meskine Djamila

Background: Transient neonatal hypothyroidism (T N HT) is a rare entity important to recognize. It is due to placental transfer of antibodies antirécepteurs of pituitary TSH. It is distinguished from permanent congenital forms of hypothyroidism, because it requires only limited substitution treatment in time.Objective and hypotheses: Report the observations of 6 children who presented T N HT.Method: This is a retrospective stu...