ESPE2016 Poster Presentations Thyroid P2 (49 abstracts)
Celiac Disease in Children and Adolescents with Hashimoto Thyroiditis
Hale Tuhan a , Sakine Isik b , Ayhan Abaci a , Erdem Simsek a , Ahmet Anik a , Ozden Anal b & Ece Bober a
aDepartment of Pediatric Endocrinology, Dokuz Eylul University, Izmir, Turkey; bDepartment of Pediatric, Allergy and Immunology, Dokuz Eylul University, Izmir, Turkey
Background: Hashimoto thyroiditis (HT) is part of the spectrum of autoimmune thyroid diseases and is characterized by the destruction of thyroid cells by various cell- and antibody-mediated immune processes.
Objective and hypotheses: The aim of this study was to evaluate clinical and laboratory findings and determine the prevalence of celiac disease (CD) in children with HT.
Method: A total of 80 patients with positive anti-thyroid antibodies who were between 6-17.9 years of age were retrospectively studied. Age, gender, symptoms at the time of presentation, family history of thyroid disorders, clinical and laboratory findings were recorded. The levels of thyrotropin, free thyroxin thyroid autoantibodies (thyroid peroxidase and thyroglobulin antibodies), immunoglobulin A (IgA) anti-tissue transglutaminase antibodies (IgA-tTG) and thyroid ultrasound were enrolled.
Results: The study consisted of a population of 80 patients with 81.2% (65) girls and 18.8% (15) boys. Family history of thyroid disease was determined in 38 (47.5%) patients. The most common symptoms were goiter (30%) and weight gain (25%). Forty three (53.8%) patients presented with euthyroidism, while 23 (28.7%) and 14 (17.5%) patients with subclinical hypothyroidism and hypothyroidism, respectively. Thirty seven (46.2%) patients had goiter. IgA-tTG was positive in only one patient (1.25%) with HT. The symptoms of CD were present and small intestine biopsy revealed villous atrophy and crypt hyperplasia in this patient.
Conclusion: In our study, the major symptoms were goiter, weakness and weight gain and only one patient (1.25%) was found to have CD. This study has shown that the prevalence of CD in children with HT is higher than in the general population.
Article tools
My recent searches
My recently viewed abstracts
ESPE Abstracts
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more