Objective: To assess the serum levels of IL-6, TNF-a and Omentin-1 in girls with Turner Syndrome (TS) and to analyze their association with FPG, FINS, TC, TG, HDL-c, LDL-c, and BMISDS.
Methods: In total of 33 TS girls aged (12.8±3.9) yr and 33 age-matched normal girls aged (12.6±3.7) yr were recruited in the study. Height (Ht) and Weight (Wt) were measured; FPG, FINS, TC, TG, HDL-c, LDL-c, IGF-1 and E2 were also measured; BMI and BMISDS were calculated. Serum IL-6, TNF-a were tested by CBA method and serum omentin-1 were tested by ELISA method.
Results: In TS group, BMI and BMISDS are greater than that in control group (all P<0.05), and the levels of TC, LDL-c, IL-6, TNF-a, omentin-1 are higher than that in control group (all P<0.05). IGF-1 and E2 levels are lower than those in control group (all P<0.01) (details in table 1). There is no statistically different of FINS, FPG and HOMA-IR between the two groups. IL-6 is positively correlated with BMISDS and TNF-a (rs=0.292, P<0.05; rs=0.565, P<0.001); TNF-a is positively correlated with BMISDS (rs=0.420, P=0.001); omentin-1 was positively correlated with BMISDS (rs=0.322, P<0.05).
|Parameters||TS group||Control group||P value|
|Body height (cm)||126.4±13.2||143.2±17.5||0.000|
|Body weight (Kg)||28.0±7.7||34.8±11.0||0.000|
Conclusions: Serum levels of IL-6, TNF-a, Omentin-1, TC, and LDL-c are increased in girls with TS. Further investigation is needed to illustrate the relationship among these factors and the metabolic disorders in TS patients.
Keywords: IL-6; TNF-a; Omenitn-1; Turner syndrome; Children and adolescents
10 - 12 Sep 2016
European Society for Paediatric Endocrinology