Background: There is a direct relation between C-reactive protein and leukocyte count as indicators of inflammation. The neutrophil lymphocyte ratio (NLR) is the balance between both cells and is considered a marker of low-grade inflammation and an indicator of high risk of cardiovascular events. An elevated NLR is related with type 2 diabetes (T2D), however, even when in type 1 diabetes (T1D) there is an underlying inflammatory process, an elevation of circulating neutrophils isnt observed. NLR is associated with hyperglycemia in adult patients with long-duration T2D. However, reports in pediatric populations with recent-onset type 1 (T1D) and T2D are scarce.
Objective and hypotheses: To evaluate the association between NLR and the degree of glycemic control in pediatric patients with recent-onset T1D and T2D vs healthy controls.
Method: Design: Analytical cross-sectional. Subjects 816 years of age were included, with T1D or T2D with diagnosis ≤ 3 months, who, with their guardians, signed an informed consent. A physical examination included anthropometric measurements. A blood sample was used for glucose, lipid profile and creatinine concentrations, hematic biometry and HbA1c. Subjects were classified according to metabolic control (good control HbA1c <7.5%).
Results: There were 131 subjects, 46 (35.1%) with T2D, 49 (37.5%) with T1D and 36 (27.4%) controls. Differences were observed among the three groups in leukocytes (7.6±2.0, 6.4±1.7 and 6.8±2.0 K/μL for T2D, T1D and controls, respectively). NLR was similar among the groups: 1.58±0.61 in T2D vs 1.55±1.07 in T1D and 1.53±1.04 in controls. According to metabolic control, NLR was significant in T2D (P=0.045) and T1D (P=0.035).
Conclusion: Our findings show higher NLR with poor glycemic control in T2D, and lower with poor control in T1D, from the early stages of the disease in Mexican pediatric population.
10 Sep 2016 - 12 Sep 2016