Background: Vitamin D deficiency may be associated with increased risk of metabolic syndrome.
Objective and hypotheses: We aimed to assess the relation between 25-hydroxyvitamin D (25(OH) D) with the different metabolic syndrome components in overweight and obese subjects.
Method: Ninety eight subjects (≥85th percentile for age and sex) recruited from the Diabetes, Endocrine & Metabolic Paediatrics Unit (DEMPU), Cairo University, were evaluated with blood pressures, anthropometric measurements, fasting measurements of serum lipid profile, insulin, blood glucose (FBS), 25(OH) D, calcium, phosphorous, and alkaline phosphatase. Homeostasis Model Assessment Method-Insulin Resistance (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) were calculated.
Results: Among 98 subjects, 29 (29.9%) were vitamin D insufficient, 64 (65.3%) were vitamin D deficient and only 5 (5.1%) had normal level of vitamin D. On correlating 25 (OH) D with metabolic and anthropometric variables, 25 (OH) D was inversely associated with both of FBS (r=−0.343, P=0.001) and weight standard deviation score (Wt SDS) (r=−0.216, P=0.033), while no correlations were detected between 25 (OH) D and each of BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), high density lipoproteins (HDL), triglycerides (TG), HOMA-IR and fasting insulin. Regression Multivariate Analysis was applied on 25 (OH) D after adjustment of age and sex, showing that Wt SDS, waist circumference (WC), hip circumference (HC), waist/hip ratio (W/H ratio), FBS, Fasting Insulin, HOMA-IR and QUICKI had significant relations with vitamin D (P=0.038, 0.025, 0.036, 0.015, 0.019, 0.007, 0.02 and 0.04, respectively).
Conclusion: Hypovitaminosis D is prevalent in obese and overweight Egyptian subjects. Significant relationship between 25 (OH) D and each of Wt SDS, WC, HC, W/H ratio, FBS, Fasting Insulin, HOMA-IR and QUICKI were suggestive of possible adverse influences of vitamin D.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology