Background: An elevated anti-Müllerian hormone (AMH) level might serve as a noninvasive screening or diagnostic test for PCOS in adolescents.
Objective and hypotheses: We explored whether the AMH levels of adolescents with PCOS, at-risk-of-PCOS, and isolated oligomenorrhea, differed from those of adolescents with normal menstrual cycles, and we identified an AMH level that was potentially diagnostic of PCOS.
Method: A diagnosis of PCOS was based on the 2012 Amsterdam (ESHRE/ASRM) criteria. The PCOS group consisted of individuals meeting all three diagnostic criteria (n=21); those in the at-risk-of-PCOS group met two of the criteria (n=20). The OM group consisted of those with isolated OM who did not satisfy the other PCOS diagnostic criteria (n=21). Thirty adolescent girls with regular menstrual cycles (2145 day) (NMC) were recruited for study.
Results: The AMH levels in the PCOS group were similar to at-risk-of-PCOS group but significantly higher than in the OM and NMC groups. The AMH levels in the at-risk-of-PCOS group were similar to the OM group and significantly higher than in the NMC group. They were also significantly higher in the OM group than in the NMC group. The sensitivity and specificity of each serum AMH concentration for identifying PCOS and at-risk-of-PCOS subjects were determined by ROC curve analysis. The specificity at a cut-off value of 7.25 ng/ml was 83.3%, and the sensitivity was 58.5%. The positive and negative predictive values of this cut-off were 82.8% and 59.5%, respectively.
Conclusion: An AMH cut-off of 7.25 ng/ml can assist in PCOS diagnosis in adolescents. However, before this criterion is used routinely, larger populations should be studied. OM subjects should be monitored for the development of PCOS.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology