Background: Childhood overt hypothyroidism is a chronic disease that affect many system adversely and requires treatment. However, subclinical hypothyroidism (SH),defined obvious cases, impacts on other systems are unknown and there is no common approach to be treated. Moreover, SH may continue for many years, before they become overt hypothyroidism. Cardiovascular system (CVS) is one of the host system, which hypothyroidism adversely affects. Epicardial adipose tissue thickness (EAT) is known to be an important marker in terms of the cardiovascular risks. We aimed to determine the effects on CVS of subclinical hypothyroidism.
Method: The study included were 25 patients with SH and 25 healthy children. SH was determined according to slightly higher TSH than the upper limit (4.2 M/l),normal free T4 and T3 levels. EAT was determined by transthoracic echocardiographic measurements in millimeters, in pediatric cardiology clinic.
Results: Anthropometric measurements of all cases, thyroid function tests and EAT values are shown table 1. Epicardial fat thickness was significantly higher in SH children, than the children without thyroid dysfunction.
|SH||Control Group||P value|
|Sex. Puberty (Prepubertal/ pubertal)||F:11 M:14 16/9||F:10 M:15 17/8||P>0.05|
|Weight||2550 percentile||50 percentile||P>0.05|
|Height||2550 percentile||2550 percentile||P>0.05|
|BMI||2550 percentile||50 percentile||P>0.05|
Conclusion: This study suggests that subclinical hypothyroidism effects adversly the cardiovascular system in children before hypothyroidism become overt. In future this data may be marker at the begining of LT4 treatment in SH with children.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology