ESPE Abstracts (2016) 86 P-P1-897

ESPE2016 Poster Presentations Thyroid P1 (48 abstracts)

Congenital Hypothyroidism: The Use of a TSH Cut-off Limit of 6mU/L and the ESPE Criteria for LT4 Treatment Leads to the Diagnosis of Mild but mostly Permanent Forms of Hypothyroidism

Anna Gika b , Alexandra Iliadi a, , Dimitris Platis b , Vasiliki Giogli b , Jessica Arditi a , Flora Tzifi a , Taxiarchis Kyrimis a , Ioannis Vasilakis a , George Chrousos a , Panagiotis Girginoudis b , Christina Kanaka-Gantenbein a & Antonis Voutetakis a

aFirst Department of Pediatrics, University of Athens, School of Medicine, “Aghia Sophia” Children’s Hospital, Athens, Greece; bDepartment of Biochemical Laboratories, Institute of Child Health, Athens, Greece

Background: Since the initiation of neonatal screening programs for Congenital Hypothyroidism (CH) in the 1970’s, a gradual decrease of TSH cut-off limits has been observed worldwide. Nevertheless, lack of universal consensus has led to wide variation of cut-off limits and LT4 therapy criteria among screening programs, even within the same country. The Greek neonatal CH screening program is carried out by a single laboratory that uses one of the lowest cut-off limits worldwide.

Objective and hypotheses: To assess the effect of using a TSH cut-off limit of 6 mU/L in Guthrie cards.

Method: The data of CH neonates born in 2009 were reviewed. At study initiation, all children were at least 6 years old and, therefore, characterization of CH as permanent or transient could be considered reliable.

Results: From a total of 120.852 newborns screened for CH in 2009, LT4 treatment was initiated in 324 (~1 in 10 recalled). Data from 224 patients were available for analysis. Patients were divided in three groups according to the Guthrie card’s TSH value: <10, 10–30 and >30 mIU/L (67%, 19% and 14% of total). CH proved transient in 41.5% (girls 35.6% and boys 45.5%), 35.7% (girls 42% and boys 28%) and 9.7% (girls 5% and boys 18%), respectively. We emphasize that 92% of patients in the <10 mU/L group, started LT4 treatment according to the latest ESPE criteria.

Conclusion: Use of a TSH cut-off limit of 6 mU/L in the CH screening program identifies milder but mostly permanent CH cases. If the screening program does not identify neonates with TSH levels between 6–10 mU/L in Guthrie cards, a substantial number of patients who fulfill the ESPE criteria for LT4-initiation will not be uncovered. Hence, the use of such low cut-off limits proves valuable with respect to the diagnosis and treatment of CH.

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