ESPE Abstracts (2016) 86 P-P2-158

Anthropometric and Nutritional Parameters in Egyptian Children with Osteogenesis Imperfecta: Effect of Zoledronic Acid Therapy

Rasha Hamzaa, Tarek Abdelaziza & Magdy Elakkadb

aAin Shams University, Cairo, Egypt; bEgyptian Health Insurance, Cairo, Egypt

Background: Patients with osteogenesis imperfect (OI) present with various degrees of short stature and nutritional disorders.

Objective and hypotheses: To evaluate anthropometric and nutritional parameters in OI children and their variability among various types.

Methods: Eighty-four patients with OI (types I, II, and IV) were subjected to the following anthropometric measurements: standing height (Ht), sitting height (SH), arm span, weight (Wt), and head circumference (HC), with calculation of Ht, SH, Wt, BMI, and HC SDSs, and relative arm span. Triceps skinfold thickness (TSFT), subscapular skinfold thickness (SSFT), and mid upper arm circumference (MUAC) were measured, as well as dietary intake of macronutrients and calcium; also, energy requirements were calculated. Ht and Wt SDSs were re-evaluated after 1 year of zoledronic acid therapy.

Results: Ht SDS was reduced in OI-III and OI-IV compared to OI-I; SH SDS was reduced in OI-III compared to OI-I. HC SDS was more increased in OI-III than in OI-I and OI-IV. BMI SDS correlated with TSFT, SSFT, and MUAC. OI-III patients had the highest percentage of energy intake. The frequency of low macronutrient and calcium intake was highest in OI-III, while the frequency of low fat intake was highest in OI-I.

Conclusion: Anthropometric and nutritional parameters differ among OI types. Assessment of anthropometric measurements and nutritional status in OI patients is important. Zoledronic acid therapy improves height SDS in such patients.

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