ESPE Abstracts

Background: Cystic fibrosis-related diabetes (CFRD) is the most common co-morbidity in association with cystic fibrosis. Cystic fibrosis related diabetes is predominantly an insulin deficiency state it shares features of both type 1 and type 2 diabetes, yet there are important differences, which necessitate a unique approach to diagnosis and management. Development of cystic fibrosis related diabetes is associated with a worse lung function, poorer nutritional status, and more chest infections.

Method: This is a retrospective study at KFSH & RC 300 Cystic fibrosis patients were reviewed including 173 females, and 127 males.

Results: At KFSH & RC 300 Cystic fibrosis patients were reviewed including 173 females (58%), and 127 males (42%). 35 (12%) patients had CFRD, 12 males (9%), 23 females (13%). 64% had developed DM before the age of 15 years. Oral glucose tolerance test (OGTT) was performed as a screening test in patients above the age of 10 years. The majority of tests were done in the years of 2014 and 2015 including 26 (8.6%) patients. 9 (34%) patients had CFRD, 9 (34%) had impaired glucose tolerance, 8 (31%) had normal glucose tolerance.

Conclusion: CFRD appeared to be more common in females than males. The onset of CFRD is very early in the studied population. Physicians started performing oral glucose tolerance test (OGTT) to screen Cystic fibrosis patients. One third of the population screened had CFRD. More studies need to be done to identify the incidence and the prevalence of CFRD among CF patients.