Background: The main purpose of insulin analogue treatment is mimicking physiologic insulin secretion and accomplishing a good glycemic control without having late hypoglycemia in patients with diabetes mellitus.
Objective and hypotheses: In this report, 24 weeks follow-up results of newly diagnosed type 1 DM patients treated with insulin lispro and insulin glulisin is discussed.
Method: Twelve patients diagnosed with type 1 DM patients in between 4 and 16 years were involved in the study. Patients were put on Insulin glarjine plus insulin glulisin (IG, Group I) or insulin lispro (IL, Group II) treatment. Patients were followed up with 1/3 month intervals. Fasting blood glucose (FBG), postprandial blood glucose (PBG), 03 AM blood glucose (03 BG) recordings of the patients, Hba1c levels and clinical evaluation of the cases were compared.
Results: Anthropometric parameters, HbA1c and blood glucose levels of the cases were evaluated. Postprandial asymptomatic hypoglycemia was observed in two patient in Group I and three patients in Group II. None of the patients had symptomatic hypoglycemia. 24 weeks follow-up results of the groups were compared. FBG and 03 BG levels of Group I was statistically lower than Group II.
Conclusion: In children and adolescents, the long interval between insulin injection and food consumption makes adaptation of daily life harder. In this study, the efficacy of insulin glulisine was found at least as good as insulin lispro. We think that the ability of application of insulin glulisine just after meals is a benefit for pediatric age group.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology