ESPE Abstracts (2016) 86 P-P2-582

Birth Chest Circumference Relations to Circulating Insulin-Like Growth Factor-I in the Not-life-threatened Newborn: Relevance of Birthweight to Birth Crown-Heel Length Ratio Beyond The Presence of a Small Birthweight for Gestational Age and of Respiratory Support Measures

Cesare Terzia, Werner F. Blumb, Cristiana Magnanic, Andrea Ceriolid, Marco Rianid, Elena Chesib, Sergio Bernasconia, Gabriele Tridentic, Gian Luigi De Angelisa, Raffaele Virdisa & Giacomo Banchinic

aDipartimento Materno-Infantile - Department of Clinical and Experimental Medicine, Parma, Emilia-Romagna, Italy; bFriedrich-Stengel-Str. 14, Usingen, Hessen, Germany; cDipartimento Materno-Infantile, IRCCS S. Maria Nuova Hospital Reggio Emilia, Reggio Emilia, Emilia-Romagna, Italy; dDepartment of Economics, University of Parma, Parma, Emilia-Romagna, Italy

Background: Birth chest circumference (BC) may be related to Insulin-like-Growth-Factor-I blood serum levels (IG1) in the human newborn (NWB).

Objective and hypotheses: We evaluated the relevance of birth body weight (BW) to birth crown-heel length (BL) ratio (BW through BL, BW/BL) in BC relations to IG1 after control for BW for birth gestational age (GA)<=10th centile (SGA), respiratory oxygen supplementation (O2S) and assisted ventilation of any kind (AV) in not-life-threatened NWBs.

Method: NWBs with any among total parenteral nutrition, life-threatening disease, diabetes mellitus (DM), endocrine diagnosis out of DM, malformation, clinically relevant trunk trauma, and mother with DM were excluded. Each of 78 included NWBs had available data for: i) gender (SEX), GA (unit: complete week; range=28–42), BW (unit:kg; range=1.200–4.150), BL (unit: m; range=0.360–0.550), BC (unit: cm; range=22.0–39.0), BW/BL (unit: kg/m; range=3.158–8.137), SGA, postnatal age (PNA; unit: day) and ii)same-day records at one of the first 5 postnatal days (x), 5 days after x (y) and 10 days after x (z) for O2S, AV, as well as IG1 RIA measurements (unit: uM/dl)(male SEX, n, 43; birth at GA≤36, n, 46; SGA, n, 20; O2S, n, x=22, y=11, z=1; AV, n, x=8, y=4, z=1). Natural log-transformed IG1 (IG1-LN) resulted near-normally distributed. Multiple Linear Regression (MLR) was used (computations; male SEX, SGA, O2S, AV, condition present=1, condition absent=0).

Results: MLR showed a significant partial correlation (PC) coefficient (r) of BC PCs with outcomes IG1-LNx-y-z when including as predictors ii) PNA, O2S and AV chronologically corresponding to IG1-LN, SEX, SGA and BC, all together (MLR1;BC vs IG1-LN; x, r : 0.38, P : 0.0011; y, r : 0.47, P<0.0000; z, r : 0.42, P: 0.0002) while no significant BC PCs with outcomes IG1-LNx-y-z were found after adding as predictor to MLR1 either iii) BW/BL(MLR2) or ii) BW/BL and GA(MLR3) (R2 of considered MLR models: 0.27–0.52, always significant).

Conclusion: BW/BL could be involved in BC relations to IG1-LN not explained by SEX, SGA, PNA, O2S and AV in the not-life-threatened NWB.