Background: Birth chest circumference (BC) may be related to Insulin-like-Growth-Factor-I blood serum levels (IG1) in the human newborn (NWB).
Objective and hypotheses: We evaluated the relevance of birth body weight (BW) to birth crown-heel length (BL) ratio (BW through BL, BW/BL) in BC relations to IG1 after control for BW for birth gestational age (GA)<=10th centile (SGA), respiratory oxygen supplementation (O2S) and assisted ventilation of any kind (AV) in not-life-threatened NWBs.
Method: NWBs with any among total parenteral nutrition, life-threatening disease, diabetes mellitus (DM), endocrine diagnosis out of DM, malformation, clinically relevant trunk trauma, and mother with DM were excluded. Each of 78 included NWBs had available data for: i) gender (SEX), GA (unit: complete week; range=2842), BW (unit:kg; range=1.2004.150), BL (unit: m; range=0.3600.550), BC (unit: cm; range=22.039.0), BW/BL (unit: kg/m; range=3.1588.137), SGA, postnatal age (PNA; unit: day) and ii)same-day records at one of the first 5 postnatal days (x), 5 days after x (y) and 10 days after x (z) for O2S, AV, as well as IG1 RIA measurements (unit: uM/dl)(male SEX, n, 43; birth at GA≤36, n, 46; SGA, n, 20; O2S, n, x=22, y=11, z=1; AV, n, x=8, y=4, z=1). Natural log-transformed IG1 (IG1-LN) resulted near-normally distributed. Multiple Linear Regression (MLR) was used (computations; male SEX, SGA, O2S, AV, condition present=1, condition absent=0).
Results: MLR showed a significant partial correlation (PC) coefficient (r) of BC PCs with outcomes IG1-LNx-y-z when including as predictors ii) PNA, O2S and AV chronologically corresponding to IG1-LN, SEX, SGA and BC, all together (MLR1;BC vs IG1-LN; x, r : 0.38, P : 0.0011; y, r : 0.47, P<0.0000; z, r : 0.42, P: 0.0002) while no significant BC PCs with outcomes IG1-LNx-y-z were found after adding as predictor to MLR1 either iii) BW/BL(MLR2) or ii) BW/BL and GA(MLR3) (R2 of considered MLR models: 0.270.52, always significant).
Conclusion: BW/BL could be involved in BC relations to IG1-LN not explained by SEX, SGA, PNA, O2S and AV in the not-life-threatened NWB.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology