Background: Vitamin D, mainly important in calcium phosphate homeostasis and bone health, has been recently suggested as an important factor in pathogenesis of numerous chronic conditions such as type 2 diabetes, metabolic syndrome and polycystic ovarian syndrome (PCOS).
Objective and hypotheses: The aim of this study is to investigate the relation between PCOS and premature adrenarche (PA), suggested as predictor of PCOS.
Method: A total of 71 girls with PA and 52 healthy girls, as the control group, were consecutively recruited. Axillar and/or pubic hair development before the age of 8 years were defined as PA. Bone age and anthropometric measures including height, weight, BMI were obtained. Levels of androgens, 25 hydroxyvitamin D (25(OH)D), 1,25 dihydroxy vitamin D (1,25(OH)2D), follicule stimulating hormone (FSH), luteinizing hormone (LH), fasting plasma glucose and insülin were measured. Vitamin D insufficiency was defined as <20 μg/ml.
Results: There were no significant differences between the patients with PA and control group with in terms of age, birthweight, 1,25(OH)2D, 11-DOCA, LH, FSH, fasting plasma glucose and insulin levels. On the other hand, bone age, BMI-SDS, HOMA-IR, and androgen levels were significantly higher in patients with PA. Vitamin D insufficiency was determined in 38 patients with PA (38/71) and in 19 healthy children (19/52). HOMA-IR was signicantly higher in patients with vitamin D insufficiency (P=0.044). There was a statistically significant correlation between 25(OH)D and HOMA-IR.
Conclusion: Vitamin D level is associated with PA and insulin resistence (IR) can be suggested as an important factor in relation between vitamin D insufficiency and PA.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology