Background: Antimüllerian hormone (AMH) is produced by granulosa cells surrounding follicles. There are limited studies about the change of AMH levels at the pubertal onset.
Objective and hypotheses: The aim of this study was to identify whether AMH levels could be diagnostic for central precocious puberty (CPP), premature thelarche and premature adrenarche (PA) and to investigate the factors influencing AMH regulation.
Method: Girls with CPP (N=21), PT (N=24), PA (N=42), control prepubertal (N=22), control pubertal (N=39) are included in the study.
Results: Chronological age in PT, PA, CPP groups was more advanced than the control prepubertal group but behind the control pubertal group. HSDS, WSDS and BMISDS were similar between the groups. AMH levels were not different between the groups. AMH levels showed a significant positive correlation with 17OHP levels in all five groups. AMH levels showed a significant negative correlation with LH, f-testosterone and DHEA-SO4 levels in the PT group. AMH levels were negatively correlated with BMI SDS values and positively correlated with SHBG levels in the CPP group. These levels were positively correlated with SHBG levels in the control prepubertal group.
Conclusion: Serum AMH level is not affected from the activation of the pubertal and adrenal axis in female children and follow a stable course in the prepubertal and pubertal years. LH, 17OHP, f-testosterone, DHEA-SO4 and SHBG are the factors that are effective in AMH regulation.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology