Background: Central precocious puberty (CPP) may result from organic lesions, but it is most frequently of idiopathic origin in girls.
Objective and hypotheses: The objective of the study was to identify central nervous system abnormalities in girls with CPP.
Method: This retrospective study was performed in 3-tertiary care hospitals between 2005 and 2015. During this period, 200 girls with CPP performed brain magnetic resonance imaging (MRI). Of the 200 girls, 12 (6.0%) were younger than 6 years, 188 (94%) were between 6 and 7 years. We analyzed the radiologic findings and evaluated related clinical and biochemical factors.
Results: Brain MRI showed no abnormalities in 183 (91.5%), abnormalities of the hypothalamic-pituitary area in 16 (8.0%), and tuber cinereum hamartoma in one girls (0.5%). Abnormalities of the hypothalamic-pituitary area included microadenoma (n=6), pituitary hypoplasia (n=5), Rathkes pouch cyst (n=3) and cyst of pituitary pars intermedia (n=2). Three (25.0%) of 12 girls aged <6 years had abnormal brain MRI findings, whereas 14 (7.4%) of 188 girls aged 67 years had abnormal brain MRI findings (P=0.054). There were no significant differences in clinical and biochemical parameters between girls with abnormal brain MRI findings and those with normal findings.
Conclusion: A small, but not negligible proportions of girls with CPP have organic lesions, most of which are benign.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology